Radiolabeled Peptides in Oncology View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-05

AUTHORS

Ronald E. Weiner, Mathew L. Thakur

ABSTRACT

There has been an exponential growth in the development of radiolabeled peptides for diagnostic and therapeutic applications in the last decade. The automated means of synthesizing these compounds in large quantities and the simplified methods of purifying, characterizing, and optimizing them have kindled attention to peptides as carrier molecules. These new techniques have accelerated the commercial development of radiolabelled peptides, which has provided additional radiopharmaceuticals for the nuclear medicine community. Peptides have many key properties including fast clearance, rapid tissue penetration, and low antigenicity, and can be produced easily and inexpensively. However, there may be problems with in vivo catabolism, unwanted physiologic effects, and chelate attachment. Radiolabeled peptides have made their greatest impact in the management of relatively rare neuroendocrine malignancies. Indeed, Indium-111 ((111)In)-pentetreotide ((111)In-DTPA-octreotide, Octreoscan), which binds to somatostatin receptors (SSTRs), has become the diagnostic 'gold standard' in these diseases. However, (111)In-pentetreotide has been less successful in the diagnosis of other more prevalent diseases in which SSTRs are upregulated. Technetium-99m (99mTc)-depreotide (NeoTect), a 99mTc-labeled SSTR-analog, could have wider impact since it has high sensitivity and specificity for lung cancer lesion detection. However, this impact may be minimized by the increased availability of positron emission tomography imaging with Fluorine-18 (18F)-flourodeoxyglucose, which has similar sensitivity and specificity for lesion identification in this disease, and is currently more widely used. The receptors for bombesin, alpha-melanocyte-stimulating hormone, neurotensin, and the integrin alpha(v)beta3, are under active investigation as targets for radiolabelled peptides, but are still in the pre-clinical stage. Compounds directed at the cholecystokinin-B/gastrin receptor have shown promising results in clinical trials in humans. Radiolabelled peptide therapy is usually indicated for patients with widespread disease that is not amenable to focused radiation therapy or is refractory to chemotherapy. Phase I/II studies using various radiolabelled peptides (including (111)In-pentetreotide, Yttrium-90 [90Y]-DOTA-Phe1-Tyr3-octreotide, 90Y-DOTA-lanreotide, and Lutetium-177 [177Lu]-DOTA-octreotate) for the treatment of patients with neuroendocrine malignancy are in progress. Over 400 patients have been treated, and the response rate has ranged from 60% to 75%, although few patients have had a complete response. Patients have been given individual doses ranging from 2 to 11 GBq with a slow infusion every 4-8 weeks (up to 12 times). The kidney is the dose-limiting organ and most patients experience a transient decline in blood cell counts. A concomitant infusion of an amino acid mixture can reduce kidney toxicity and increase the effective tumor dose. Other peptides currently under investigation, some of which have shown promising results, include Rhenium-188 (188Re)-P2045 and 90Y-alpha(v)beta3 antagonist. More... »

PAGES

145-163

References to SciGraph publications

  • 2000-03. Affinity profiles for human somatostatin receptor subtypes SST1–SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1997-07. DOTATOC: A powerful new tool for receptor-mediated radionuclide therapy in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-04. Targeting of cholecystokinin-B/gastrin receptors in vivo: preclinical and initial clinical evaluation of the diagnostic and therapeutic potential of radiolabelled gastrin in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1993-08. Somatostatin receptor scintigraphy with [111In-DTPA-d-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-03. Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotate in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-10. End-stage renal disease after treatment with 90Y-DOTATOC in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-09. [177Lu-DOTA0,Tyr3]octreotate: comparison with [111In-DTPA0]octreotide in patients in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2000-06. Phase I/II 90Y-Zevalin (yttrium-90 ibritumomab tiuxetan, IDEC-Y2B8) radioimmunotherapy dosimetry results in relapsed or refractory non-Hodgkin’s lymphoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-12. Biokinetics and imaging with the somatostatin receptor PET radioligand 68Ga-DOTATOC: preliminary data in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-04. General aspects of the cellular response to low- and high-LET radiation in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1994-12. Indium-111 pentetreotide in the diagnostic work-up of patients with bronchogenic carcinoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-02. [99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-04. 86Y-DOTA0-d-Phe1-Tyr3-octreotide (SMT487)—a phase 1 clinical study: pharmacokinetics, biodistribution and renal protective effect of different regimens of amino acid co-infusion in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-01. Safe and effective inhibition of renal uptake of radiolabelled octreotide by a combination of lysine and arginine in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-06. Benefit of anatomical-functional image fusion in the diagnostic work-up of neuroendocrine neoplasms in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1994-10. The value of octreotide scintigraphy in patients with lung cancer in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2001-03. Autocrine and paracrine signaling through neuropeptide receptors in human cancer in ONCOGENE
  • 1994. Peptides in Biomedical Sciences: Principles and Practice in RADIOLABELED BLOOD ELEMENTS
  • 1999-10. Yttrium-90 DOTATOC: first clinical results in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1998-02. Somatostatin receptor scintigraphy using [111In-DTPA0]RC-160 in humans: a comparison with [111In-DTPA0]octreotide in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-04. Zollinger-Ellison syndrome in CURRENT TREATMENT OPTIONS IN GASTROENTEROLOGY
  • 2001-12. Preliminary data on biodistribution and dosimetry for therapy planning of somatostatin receptor positive tumours: comparison of 86Y-DOTATOC and 111In-DTPA-octreotide in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2003-02. Receptor-mediated radionuclide therapy with 90Y-DOTATOC in association with amino acid infusion: a phase I study in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2165/00063030-200519030-00002

    DOI

    http://dx.doi.org/10.2165/00063030-200519030-00002

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044691528

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15984900


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radionuclide Imaging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radiopharmaceuticals", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Connecticut Health Center", 
              "id": "https://www.grid.ac/institutes/grid.208078.5", 
              "name": [
                "Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington, Connecticut, USA", 
                "Division of Nuclear Medicine MC-2804, University of Connecticut Health Center, 263 Farmington Ave, 06030-2804, Farmington, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weiner", 
            "givenName": "Ronald E.", 
            "id": "sg:person.0757213221.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757213221.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Thomas Jefferson University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.412726.4", 
              "name": [
                "Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thakur", 
            "givenName": "Mathew L.", 
            "id": "sg:person.01244322375.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244322375.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/annonc/mdg160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000426328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-8049(94)00351-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000756264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200102000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004962811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200102000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004962811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3011.1997.tb01200.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005092346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-3011.1997.tb01200.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005092346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.117.5.1232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005872047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.117.5.1232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005872047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-199310000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005939641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-199310000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005939641"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00181066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006743083", 
              "https://doi.org/10.1007/bf00181066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-002-1040-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008790613", 
              "https://doi.org/10.1007/s00259-002-1040-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2002.126059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009035555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2002.126059", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009035555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.10349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009878961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2002.31769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011217908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199410273311703", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012074254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200011000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012796888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200011000-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012796888"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-003-1160-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013934660", 
              "https://doi.org/10.1007/s00259-003-1160-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)92637-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014255500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(94)92637-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014255500"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/10.suppl_4.s177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014615335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(98)02286-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014869518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/92.3.179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015536622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015782959", 
              "https://doi.org/10.1038/sj.onc.1204183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015782959", 
              "https://doi.org/10.1038/sj.onc.1204183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00130404-200209000-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016401168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00130404-200209000-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016401168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.10337", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016892449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00181765", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016946247", 
              "https://doi.org/10.1007/bf00181765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2000.tb06949.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016991642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590100484", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018094400", 
              "https://doi.org/10.1007/s002590100484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00879669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020091243", 
              "https://doi.org/10.1007/bf00879669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000049168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021181735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(20010601)92:5<628::aid-ijc1244>3.0.co;2-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021202182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590000276", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023379051", 
              "https://doi.org/10.1007/s002590000276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1072-7515(00)00222-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024494225"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590100599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024652684", 
              "https://doi.org/10.1007/s002590100599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.10256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024813900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2002.31565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030421791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc/2002.31025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031251521"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/snuc.2001.27045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031737213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0016-5085(00)84188-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033450359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(20000820)90:4<186::aid-ijc2>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033781762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0215(20000820)90:4<186::aid-ijc2>3.0.co;2-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033781762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(01)00555-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035062031"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-8051(01)00284-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035393192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.49.11.952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036373153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590050034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036382831", 
              "https://doi.org/10.1007/s002590050034"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-003-1117-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036573184", 
              "https://doi.org/10.1007/s00259-003-1117-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0969-8051(96)00068-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037714858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-894x(98)00187-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038085561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2462-5_29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038099672", 
              "https://doi.org/10.1007/978-1-4615-2462-5_29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2462-5_29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038099672", 
              "https://doi.org/10.1007/978-1-4615-2462-5_29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(05)78355-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039610203"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-894x(03)00552-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040801121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-894x(03)00552-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040801121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590100628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040840867", 
              "https://doi.org/10.1007/s002590100628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/0470846380.ch11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041874024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590100639", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043340826", 
              "https://doi.org/10.1007/s002590100639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-199912000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044008438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-199912000-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044008438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910610608", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044221490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590100574", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045446163", 
              "https://doi.org/10.1007/s002590100574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-002-1050-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045597456", 
              "https://doi.org/10.1007/s00259-002-1050-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-002-1050-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045597456", 
              "https://doi.org/10.1007/s00259-002-1050-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-002-0982-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046951944", 
              "https://doi.org/10.1007/s00259-002-0982-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11938-003-0017-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047308881", 
              "https://doi.org/10.1007/s11938-003-0017-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590050241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048289543", 
              "https://doi.org/10.1007/s002590050241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/canjclin.43.1.7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048602968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590050476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049195855", 
              "https://doi.org/10.1007/s002590050476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002590050213", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050382106", 
              "https://doi.org/10.1007/s002590050213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-8051(01)00205-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050484105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00259-002-1023-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050769026", 
              "https://doi.org/10.1007/s00259-002-1023-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02426696", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051305362", 
              "https://doi.org/10.1007/bf02426696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/er.2000-0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051437649"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(89)91258-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052007458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/bip.10356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053289531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc010074f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc010074f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc0155566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc0155566", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015585g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc015585g", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc020034r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc020034r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055153332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc970031s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc970031s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc9701959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bc9701959", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055156264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/81.12.900", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059815165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200006000-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060254968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200006000-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060254968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200006000-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060254968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00006231-200006000-00023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060254968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/edrv-12-4-450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064237961"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1064244178", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/endo.140.11.7126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064282769"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1381612033391621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069164803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo.9.3.445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071517872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-125-1-199607010-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073700529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074252657", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1999.17.2.615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074265662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074360717", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074508927", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074569430", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074581332", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2000.18.6.1331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074604334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074604536", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074624293", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074639426", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074675035", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074681243", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074684038", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074700338", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074714375", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074772148", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074772150", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074772164", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074844492", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074844508", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074858295", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074874245", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074951131", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074964198", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075047030", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075185032", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075200338", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075200346", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075213862", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075247784", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075264834", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075327671", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076576997", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076822362", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078722004", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079819222", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082413660", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082413676", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082413680", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082512535", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082760395", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082956290", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083020071", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083071665", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083104169", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083216203", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083258959", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083292780", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083318925", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083352466", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2005-05", 
        "datePublishedReg": "2005-05-01", 
        "description": "There has been an exponential growth in the development of radiolabeled peptides for diagnostic and therapeutic applications in the last decade. The automated means of synthesizing these compounds in large quantities and the simplified methods of purifying, characterizing, and optimizing them have kindled attention to peptides as carrier molecules. These new techniques have accelerated the commercial development of radiolabelled peptides, which has provided additional radiopharmaceuticals for the nuclear medicine community. Peptides have many key properties including fast clearance, rapid tissue penetration, and low antigenicity, and can be produced easily and inexpensively. However, there may be problems with in vivo catabolism, unwanted physiologic effects, and chelate attachment. Radiolabeled peptides have made their greatest impact in the management of relatively rare neuroendocrine malignancies. Indeed, Indium-111 ((111)In)-pentetreotide ((111)In-DTPA-octreotide, Octreoscan), which binds to somatostatin receptors (SSTRs), has become the diagnostic 'gold standard' in these diseases. However, (111)In-pentetreotide has been less successful in the diagnosis of other more prevalent diseases in which SSTRs are upregulated. Technetium-99m (99mTc)-depreotide (NeoTect), a 99mTc-labeled SSTR-analog, could have wider impact since it has high sensitivity and specificity for lung cancer lesion detection. However, this impact may be minimized by the increased availability of positron emission tomography imaging with Fluorine-18 (18F)-flourodeoxyglucose, which has similar sensitivity and specificity for lesion identification in this disease, and is currently more widely used. The receptors for bombesin, alpha-melanocyte-stimulating hormone, neurotensin, and the integrin alpha(v)beta3, are under active investigation as targets for radiolabelled peptides, but are still in the pre-clinical stage. Compounds directed at the cholecystokinin-B/gastrin receptor have shown promising results in clinical trials in humans. Radiolabelled peptide therapy is usually indicated for patients with widespread disease that is not amenable to focused radiation therapy or is refractory to chemotherapy. Phase I/II studies using various radiolabelled peptides (including (111)In-pentetreotide, Yttrium-90 [90Y]-DOTA-Phe1-Tyr3-octreotide, 90Y-DOTA-lanreotide, and Lutetium-177 [177Lu]-DOTA-octreotate) for the treatment of patients with neuroendocrine malignancy are in progress. Over 400 patients have been treated, and the response rate has ranged from 60% to 75%, although few patients have had a complete response. Patients have been given individual doses ranging from 2 to 11 GBq with a slow infusion every 4-8 weeks (up to 12 times). The kidney is the dose-limiting organ and most patients experience a transient decline in blood cell counts. A concomitant infusion of an amino acid mixture can reduce kidney toxicity and increase the effective tumor dose. Other peptides currently under investigation, some of which have shown promising results, include Rhenium-188 (188Re)-P2045 and 90Y-alpha(v)beta3 antagonist.", 
        "genre": "research_article", 
        "id": "sg:pub.10.2165/00063030-200519030-00002", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1111842", 
            "issn": [
              "1173-8804", 
              "1179-190X"
            ], 
            "name": "BioDrugs", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "Radiolabeled Peptides in Oncology", 
        "pagination": "145-163", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d4e2063e7b3c33c3143fdb00b9ca1038e3dcd52fc7dfb65757831b5e44d0c755"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15984900"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9705305"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.2165/00063030-200519030-00002"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044691528"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.2165/00063030-200519030-00002", 
          "https://app.dimensions.ai/details/publication/pub.1044691528"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70032_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.2165/00063030-200519030-00002"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/00063030-200519030-00002'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/00063030-200519030-00002'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/00063030-200519030-00002'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/00063030-200519030-00002'


     

    This table displays all metadata directly associated to this object as RDF triples.

    461 TRIPLES      21 PREDICATES      163 URIs      26 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.2165/00063030-200519030-00002 schema:about N0cc804bc75784190ad150b42f3ed0867
    2 N21e086bf00f0443891487ee2598f6590
    3 N2ca84ec3526f4a6fa2c672742b808c9b
    4 Ncb966cd29e8344a184e6ce48b7225f56
    5 Ne5b89757ea8c423c844054b2dcb2eabb
    6 anzsrc-for:11
    7 anzsrc-for:1103
    8 schema:author Nfbf46c272f2748fbba8616e230bc3a04
    9 schema:citation sg:pub.10.1007/978-1-4615-2462-5_29
    10 sg:pub.10.1007/bf00181066
    11 sg:pub.10.1007/bf00181765
    12 sg:pub.10.1007/bf00879669
    13 sg:pub.10.1007/bf02426696
    14 sg:pub.10.1007/s00259-002-0982-3
    15 sg:pub.10.1007/s00259-002-1023-y
    16 sg:pub.10.1007/s00259-002-1040-x
    17 sg:pub.10.1007/s00259-002-1050-8
    18 sg:pub.10.1007/s00259-003-1117-1
    19 sg:pub.10.1007/s00259-003-1160-y
    20 sg:pub.10.1007/s002590000276
    21 sg:pub.10.1007/s002590050034
    22 sg:pub.10.1007/s002590050213
    23 sg:pub.10.1007/s002590050241
    24 sg:pub.10.1007/s002590050476
    25 sg:pub.10.1007/s002590100484
    26 sg:pub.10.1007/s002590100574
    27 sg:pub.10.1007/s002590100599
    28 sg:pub.10.1007/s002590100628
    29 sg:pub.10.1007/s002590100639
    30 sg:pub.10.1007/s11938-003-0017-6
    31 sg:pub.10.1038/sj.onc.1204183
    32 https://app.dimensions.ai/details/publication/pub.1064244178
    33 https://app.dimensions.ai/details/publication/pub.1074252657
    34 https://app.dimensions.ai/details/publication/pub.1074360717
    35 https://app.dimensions.ai/details/publication/pub.1074508927
    36 https://app.dimensions.ai/details/publication/pub.1074569430
    37 https://app.dimensions.ai/details/publication/pub.1074581332
    38 https://app.dimensions.ai/details/publication/pub.1074604536
    39 https://app.dimensions.ai/details/publication/pub.1074624293
    40 https://app.dimensions.ai/details/publication/pub.1074639426
    41 https://app.dimensions.ai/details/publication/pub.1074675035
    42 https://app.dimensions.ai/details/publication/pub.1074681243
    43 https://app.dimensions.ai/details/publication/pub.1074684038
    44 https://app.dimensions.ai/details/publication/pub.1074700338
    45 https://app.dimensions.ai/details/publication/pub.1074714375
    46 https://app.dimensions.ai/details/publication/pub.1074772148
    47 https://app.dimensions.ai/details/publication/pub.1074772150
    48 https://app.dimensions.ai/details/publication/pub.1074772164
    49 https://app.dimensions.ai/details/publication/pub.1074844492
    50 https://app.dimensions.ai/details/publication/pub.1074844508
    51 https://app.dimensions.ai/details/publication/pub.1074858295
    52 https://app.dimensions.ai/details/publication/pub.1074874245
    53 https://app.dimensions.ai/details/publication/pub.1074951131
    54 https://app.dimensions.ai/details/publication/pub.1074964198
    55 https://app.dimensions.ai/details/publication/pub.1075047030
    56 https://app.dimensions.ai/details/publication/pub.1075185032
    57 https://app.dimensions.ai/details/publication/pub.1075200338
    58 https://app.dimensions.ai/details/publication/pub.1075200346
    59 https://app.dimensions.ai/details/publication/pub.1075213862
    60 https://app.dimensions.ai/details/publication/pub.1075247784
    61 https://app.dimensions.ai/details/publication/pub.1075264834
    62 https://app.dimensions.ai/details/publication/pub.1075327671
    63 https://app.dimensions.ai/details/publication/pub.1076576997
    64 https://app.dimensions.ai/details/publication/pub.1076822362
    65 https://app.dimensions.ai/details/publication/pub.1078722004
    66 https://app.dimensions.ai/details/publication/pub.1079819222
    67 https://app.dimensions.ai/details/publication/pub.1082413660
    68 https://app.dimensions.ai/details/publication/pub.1082413676
    69 https://app.dimensions.ai/details/publication/pub.1082413680
    70 https://app.dimensions.ai/details/publication/pub.1082512535
    71 https://app.dimensions.ai/details/publication/pub.1082760395
    72 https://app.dimensions.ai/details/publication/pub.1082956290
    73 https://app.dimensions.ai/details/publication/pub.1083020071
    74 https://app.dimensions.ai/details/publication/pub.1083071665
    75 https://app.dimensions.ai/details/publication/pub.1083104169
    76 https://app.dimensions.ai/details/publication/pub.1083216203
    77 https://app.dimensions.ai/details/publication/pub.1083258959
    78 https://app.dimensions.ai/details/publication/pub.1083292780
    79 https://app.dimensions.ai/details/publication/pub.1083318925
    80 https://app.dimensions.ai/details/publication/pub.1083352466
    81 https://doi.org/10.1002/0470846380.ch11
    82 https://doi.org/10.1002/1097-0215(20000820)90:4<186::aid-ijc2>3.0.co;2-p
    83 https://doi.org/10.1002/1097-0215(20010601)92:5<628::aid-ijc1244>3.0.co;2-l
    84 https://doi.org/10.1002/bip.10256
    85 https://doi.org/10.1002/bip.10349
    86 https://doi.org/10.1002/bip.10356
    87 https://doi.org/10.1002/cncr.10337
    88 https://doi.org/10.1002/ijc.2910610608
    89 https://doi.org/10.1016/0959-8049(94)00351-5
    90 https://doi.org/10.1016/0969-8051(96)00068-6
    91 https://doi.org/10.1016/s0016-5085(00)84188-8
    92 https://doi.org/10.1016/s0140-6736(05)78355-0
    93 https://doi.org/10.1016/s0140-6736(89)91258-0
    94 https://doi.org/10.1016/s0140-6736(94)92637-9
    95 https://doi.org/10.1016/s0140-6736(98)02286-7
    96 https://doi.org/10.1016/s0960-894x(03)00552-3
    97 https://doi.org/10.1016/s0960-894x(98)00187-5
    98 https://doi.org/10.1016/s0969-8051(01)00205-0
    99 https://doi.org/10.1016/s0969-8051(01)00284-0
    100 https://doi.org/10.1016/s1072-7515(00)00222-2
    101 https://doi.org/10.1016/s1470-2045(01)00555-1
    102 https://doi.org/10.1021/bc010074f
    103 https://doi.org/10.1021/bc0155566
    104 https://doi.org/10.1021/bc015585g
    105 https://doi.org/10.1021/bc020034r
    106 https://doi.org/10.1021/bc970031s
    107 https://doi.org/10.1021/bc9701959
    108 https://doi.org/10.1053/snuc.2001.27045
    109 https://doi.org/10.1053/snuc.2002.126059
    110 https://doi.org/10.1053/snuc.2002.31565
    111 https://doi.org/10.1053/snuc.2002.31769
    112 https://doi.org/10.1053/snuc/2002.31025
    113 https://doi.org/10.1056/nejm199410273311703
    114 https://doi.org/10.1093/annonc/10.suppl_4.s177
    115 https://doi.org/10.1093/annonc/mdg160
    116 https://doi.org/10.1093/jnci/81.12.900
    117 https://doi.org/10.1093/jnci/92.3.179
    118 https://doi.org/10.1097/00006231-199310000-00007
    119 https://doi.org/10.1097/00006231-199912000-00002
    120 https://doi.org/10.1097/00006231-200006000-00023
    121 https://doi.org/10.1097/00006231-200011000-00013
    122 https://doi.org/10.1097/00006231-200102000-00013
    123 https://doi.org/10.1097/00130404-200209000-00011
    124 https://doi.org/10.1111/j.1399-3011.1997.tb01200.x
    125 https://doi.org/10.1111/j.1749-6632.2000.tb06949.x
    126 https://doi.org/10.1136/jcp.49.11.952
    127 https://doi.org/10.1159/000049168
    128 https://doi.org/10.1200/jco.1999.17.2.615
    129 https://doi.org/10.1200/jco.2000.18.6.1331
    130 https://doi.org/10.1210/edrv-12-4-450
    131 https://doi.org/10.1210/endo.140.11.7126
    132 https://doi.org/10.1210/er.2000-0001
    133 https://doi.org/10.1378/chest.117.5.1232
    134 https://doi.org/10.2174/1381612033391621
    135 https://doi.org/10.3322/canjclin.43.1.7
    136 https://doi.org/10.3892/ijo.9.3.445
    137 https://doi.org/10.7326/0003-4819-125-1-199607010-00005
    138 schema:datePublished 2005-05
    139 schema:datePublishedReg 2005-05-01
    140 schema:description There has been an exponential growth in the development of radiolabeled peptides for diagnostic and therapeutic applications in the last decade. The automated means of synthesizing these compounds in large quantities and the simplified methods of purifying, characterizing, and optimizing them have kindled attention to peptides as carrier molecules. These new techniques have accelerated the commercial development of radiolabelled peptides, which has provided additional radiopharmaceuticals for the nuclear medicine community. Peptides have many key properties including fast clearance, rapid tissue penetration, and low antigenicity, and can be produced easily and inexpensively. However, there may be problems with in vivo catabolism, unwanted physiologic effects, and chelate attachment. Radiolabeled peptides have made their greatest impact in the management of relatively rare neuroendocrine malignancies. Indeed, Indium-111 ((111)In)-pentetreotide ((111)In-DTPA-octreotide, Octreoscan), which binds to somatostatin receptors (SSTRs), has become the diagnostic 'gold standard' in these diseases. However, (111)In-pentetreotide has been less successful in the diagnosis of other more prevalent diseases in which SSTRs are upregulated. Technetium-99m (99mTc)-depreotide (NeoTect), a 99mTc-labeled SSTR-analog, could have wider impact since it has high sensitivity and specificity for lung cancer lesion detection. However, this impact may be minimized by the increased availability of positron emission tomography imaging with Fluorine-18 (18F)-flourodeoxyglucose, which has similar sensitivity and specificity for lesion identification in this disease, and is currently more widely used. The receptors for bombesin, alpha-melanocyte-stimulating hormone, neurotensin, and the integrin alpha(v)beta3, are under active investigation as targets for radiolabelled peptides, but are still in the pre-clinical stage. Compounds directed at the cholecystokinin-B/gastrin receptor have shown promising results in clinical trials in humans. Radiolabelled peptide therapy is usually indicated for patients with widespread disease that is not amenable to focused radiation therapy or is refractory to chemotherapy. Phase I/II studies using various radiolabelled peptides (including (111)In-pentetreotide, Yttrium-90 [90Y]-DOTA-Phe1-Tyr3-octreotide, 90Y-DOTA-lanreotide, and Lutetium-177 [177Lu]-DOTA-octreotate) for the treatment of patients with neuroendocrine malignancy are in progress. Over 400 patients have been treated, and the response rate has ranged from 60% to 75%, although few patients have had a complete response. Patients have been given individual doses ranging from 2 to 11 GBq with a slow infusion every 4-8 weeks (up to 12 times). The kidney is the dose-limiting organ and most patients experience a transient decline in blood cell counts. A concomitant infusion of an amino acid mixture can reduce kidney toxicity and increase the effective tumor dose. Other peptides currently under investigation, some of which have shown promising results, include Rhenium-188 (188Re)-P2045 and 90Y-alpha(v)beta3 antagonist.
    141 schema:genre research_article
    142 schema:inLanguage en
    143 schema:isAccessibleForFree false
    144 schema:isPartOf N311cb5cf844a4d5cac85739b0a27416d
    145 N37fa564191934cd9b3efe9028984288b
    146 sg:journal.1111842
    147 schema:name Radiolabeled Peptides in Oncology
    148 schema:pagination 145-163
    149 schema:productId N439c6e8afa9944f5aa308d4da5ea6c65
    150 N63430830b6e54407acf86e0c974d2090
    151 N759c03edbd764abfa8eea4845abcdb9c
    152 Nac642dcb16df4ae888f3f435860534e6
    153 Nca392d534693434d88925d2edcef1cd6
    154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044691528
    155 https://doi.org/10.2165/00063030-200519030-00002
    156 schema:sdDatePublished 2019-04-11T12:37
    157 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    158 schema:sdPublisher N2aebb7ad4087438993a9f483ba51820c
    159 schema:url http://link.springer.com/10.2165/00063030-200519030-00002
    160 sgo:license sg:explorer/license/
    161 sgo:sdDataset articles
    162 rdf:type schema:ScholarlyArticle
    163 N0cc804bc75784190ad150b42f3ed0867 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Neoplasms
    165 rdf:type schema:DefinedTerm
    166 N21e086bf00f0443891487ee2598f6590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Radiopharmaceuticals
    168 rdf:type schema:DefinedTerm
    169 N2aebb7ad4087438993a9f483ba51820c schema:name Springer Nature - SN SciGraph project
    170 rdf:type schema:Organization
    171 N2ca84ec3526f4a6fa2c672742b808c9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Peptides
    173 rdf:type schema:DefinedTerm
    174 N311cb5cf844a4d5cac85739b0a27416d schema:issueNumber 3
    175 rdf:type schema:PublicationIssue
    176 N37fa564191934cd9b3efe9028984288b schema:volumeNumber 19
    177 rdf:type schema:PublicationVolume
    178 N439c6e8afa9944f5aa308d4da5ea6c65 schema:name dimensions_id
    179 schema:value pub.1044691528
    180 rdf:type schema:PropertyValue
    181 N63430830b6e54407acf86e0c974d2090 schema:name doi
    182 schema:value 10.2165/00063030-200519030-00002
    183 rdf:type schema:PropertyValue
    184 N759c03edbd764abfa8eea4845abcdb9c schema:name nlm_unique_id
    185 schema:value 9705305
    186 rdf:type schema:PropertyValue
    187 N8778dcba8e114bcd933ce5e814c90c56 rdf:first sg:person.01244322375.35
    188 rdf:rest rdf:nil
    189 Nac642dcb16df4ae888f3f435860534e6 schema:name pubmed_id
    190 schema:value 15984900
    191 rdf:type schema:PropertyValue
    192 Nca392d534693434d88925d2edcef1cd6 schema:name readcube_id
    193 schema:value d4e2063e7b3c33c3143fdb00b9ca1038e3dcd52fc7dfb65757831b5e44d0c755
    194 rdf:type schema:PropertyValue
    195 Ncb966cd29e8344a184e6ce48b7225f56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Radionuclide Imaging
    197 rdf:type schema:DefinedTerm
    198 Ne5b89757ea8c423c844054b2dcb2eabb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Humans
    200 rdf:type schema:DefinedTerm
    201 Nfbf46c272f2748fbba8616e230bc3a04 rdf:first sg:person.0757213221.19
    202 rdf:rest N8778dcba8e114bcd933ce5e814c90c56
    203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Medical and Health Sciences
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Clinical Sciences
    208 rdf:type schema:DefinedTerm
    209 sg:journal.1111842 schema:issn 1173-8804
    210 1179-190X
    211 schema:name BioDrugs
    212 rdf:type schema:Periodical
    213 sg:person.01244322375.35 schema:affiliation https://www.grid.ac/institutes/grid.412726.4
    214 schema:familyName Thakur
    215 schema:givenName Mathew L.
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244322375.35
    217 rdf:type schema:Person
    218 sg:person.0757213221.19 schema:affiliation https://www.grid.ac/institutes/grid.208078.5
    219 schema:familyName Weiner
    220 schema:givenName Ronald E.
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757213221.19
    222 rdf:type schema:Person
    223 sg:pub.10.1007/978-1-4615-2462-5_29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038099672
    224 https://doi.org/10.1007/978-1-4615-2462-5_29
    225 rdf:type schema:CreativeWork
    226 sg:pub.10.1007/bf00181066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006743083
    227 https://doi.org/10.1007/bf00181066
    228 rdf:type schema:CreativeWork
    229 sg:pub.10.1007/bf00181765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016946247
    230 https://doi.org/10.1007/bf00181765
    231 rdf:type schema:CreativeWork
    232 sg:pub.10.1007/bf00879669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020091243
    233 https://doi.org/10.1007/bf00879669
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/bf02426696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051305362
    236 https://doi.org/10.1007/bf02426696
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1007/s00259-002-0982-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046951944
    239 https://doi.org/10.1007/s00259-002-0982-3
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1007/s00259-002-1023-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1050769026
    242 https://doi.org/10.1007/s00259-002-1023-y
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s00259-002-1040-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008790613
    245 https://doi.org/10.1007/s00259-002-1040-x
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s00259-002-1050-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045597456
    248 https://doi.org/10.1007/s00259-002-1050-8
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s00259-003-1117-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036573184
    251 https://doi.org/10.1007/s00259-003-1117-1
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s00259-003-1160-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1013934660
    254 https://doi.org/10.1007/s00259-003-1160-y
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/s002590000276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023379051
    257 https://doi.org/10.1007/s002590000276
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/s002590050034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036382831
    260 https://doi.org/10.1007/s002590050034
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/s002590050213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050382106
    263 https://doi.org/10.1007/s002590050213
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/s002590050241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048289543
    266 https://doi.org/10.1007/s002590050241
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/s002590050476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049195855
    269 https://doi.org/10.1007/s002590050476
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/s002590100484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018094400
    272 https://doi.org/10.1007/s002590100484
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/s002590100574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045446163
    275 https://doi.org/10.1007/s002590100574
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s002590100599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024652684
    278 https://doi.org/10.1007/s002590100599
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/s002590100628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040840867
    281 https://doi.org/10.1007/s002590100628
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s002590100639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043340826
    284 https://doi.org/10.1007/s002590100639
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s11938-003-0017-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047308881
    287 https://doi.org/10.1007/s11938-003-0017-6
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/sj.onc.1204183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015782959
    290 https://doi.org/10.1038/sj.onc.1204183
    291 rdf:type schema:CreativeWork
    292 https://app.dimensions.ai/details/publication/pub.1064244178 schema:CreativeWork
    293 https://app.dimensions.ai/details/publication/pub.1074252657 schema:CreativeWork
    294 https://app.dimensions.ai/details/publication/pub.1074360717 schema:CreativeWork
    295 https://app.dimensions.ai/details/publication/pub.1074508927 schema:CreativeWork
    296 https://app.dimensions.ai/details/publication/pub.1074569430 schema:CreativeWork
    297 https://app.dimensions.ai/details/publication/pub.1074581332 schema:CreativeWork
    298 https://app.dimensions.ai/details/publication/pub.1074604536 schema:CreativeWork
    299 https://app.dimensions.ai/details/publication/pub.1074624293 schema:CreativeWork
    300 https://app.dimensions.ai/details/publication/pub.1074639426 schema:CreativeWork
    301 https://app.dimensions.ai/details/publication/pub.1074675035 schema:CreativeWork
    302 https://app.dimensions.ai/details/publication/pub.1074681243 schema:CreativeWork
    303 https://app.dimensions.ai/details/publication/pub.1074684038 schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1074700338 schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1074714375 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1074772148 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1074772150 schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1074772164 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1074844492 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1074844508 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1074858295 schema:CreativeWork
    312 https://app.dimensions.ai/details/publication/pub.1074874245 schema:CreativeWork
    313 https://app.dimensions.ai/details/publication/pub.1074951131 schema:CreativeWork
    314 https://app.dimensions.ai/details/publication/pub.1074964198 schema:CreativeWork
    315 https://app.dimensions.ai/details/publication/pub.1075047030 schema:CreativeWork
    316 https://app.dimensions.ai/details/publication/pub.1075185032 schema:CreativeWork
    317 https://app.dimensions.ai/details/publication/pub.1075200338 schema:CreativeWork
    318 https://app.dimensions.ai/details/publication/pub.1075200346 schema:CreativeWork
    319 https://app.dimensions.ai/details/publication/pub.1075213862 schema:CreativeWork
    320 https://app.dimensions.ai/details/publication/pub.1075247784 schema:CreativeWork
    321 https://app.dimensions.ai/details/publication/pub.1075264834 schema:CreativeWork
    322 https://app.dimensions.ai/details/publication/pub.1075327671 schema:CreativeWork
    323 https://app.dimensions.ai/details/publication/pub.1076576997 schema:CreativeWork
    324 https://app.dimensions.ai/details/publication/pub.1076822362 schema:CreativeWork
    325 https://app.dimensions.ai/details/publication/pub.1078722004 schema:CreativeWork
    326 https://app.dimensions.ai/details/publication/pub.1079819222 schema:CreativeWork
    327 https://app.dimensions.ai/details/publication/pub.1082413660 schema:CreativeWork
    328 https://app.dimensions.ai/details/publication/pub.1082413676 schema:CreativeWork
    329 https://app.dimensions.ai/details/publication/pub.1082413680 schema:CreativeWork
    330 https://app.dimensions.ai/details/publication/pub.1082512535 schema:CreativeWork
    331 https://app.dimensions.ai/details/publication/pub.1082760395 schema:CreativeWork
    332 https://app.dimensions.ai/details/publication/pub.1082956290 schema:CreativeWork
    333 https://app.dimensions.ai/details/publication/pub.1083020071 schema:CreativeWork
    334 https://app.dimensions.ai/details/publication/pub.1083071665 schema:CreativeWork
    335 https://app.dimensions.ai/details/publication/pub.1083104169 schema:CreativeWork
    336 https://app.dimensions.ai/details/publication/pub.1083216203 schema:CreativeWork
    337 https://app.dimensions.ai/details/publication/pub.1083258959 schema:CreativeWork
    338 https://app.dimensions.ai/details/publication/pub.1083292780 schema:CreativeWork
    339 https://app.dimensions.ai/details/publication/pub.1083318925 schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1083352466 schema:CreativeWork
    341 https://doi.org/10.1002/0470846380.ch11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041874024
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1002/1097-0215(20000820)90:4<186::aid-ijc2>3.0.co;2-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1033781762
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1002/1097-0215(20010601)92:5<628::aid-ijc1244>3.0.co;2-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1021202182
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1002/bip.10256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024813900
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1002/bip.10349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009878961
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1002/bip.10356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053289531
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/cncr.10337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016892449
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1002/ijc.2910610608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044221490
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/0959-8049(94)00351-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000756264
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/0969-8051(96)00068-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037714858
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/s0016-5085(00)84188-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033450359
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/s0140-6736(05)78355-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039610203
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/s0140-6736(89)91258-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052007458
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/s0140-6736(94)92637-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014255500
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/s0140-6736(98)02286-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014869518
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/s0960-894x(03)00552-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040801121
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/s0960-894x(98)00187-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038085561
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s0969-8051(01)00205-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050484105
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/s0969-8051(01)00284-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035393192
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/s1072-7515(00)00222-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024494225
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/s1470-2045(01)00555-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035062031
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1021/bc010074f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153218
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1021/bc0155566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153281
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1021/bc015585g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153306
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1021/bc020034r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055153332
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1021/bc970031s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156135
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1021/bc9701959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156264
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1053/snuc.2001.27045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031737213
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1053/snuc.2002.126059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009035555
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1053/snuc.2002.31565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030421791
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1053/snuc.2002.31769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011217908
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1053/snuc/2002.31025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031251521
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1056/nejm199410273311703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012074254
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1093/annonc/10.suppl_4.s177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014615335
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1093/annonc/mdg160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000426328
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1093/jnci/81.12.900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059815165
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/jnci/92.3.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015536622
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1097/00006231-199310000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005939641
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1097/00006231-199912000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044008438
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1097/00006231-200006000-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060254968
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1097/00006231-200011000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012796888
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1097/00006231-200102000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004962811
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1097/00130404-200209000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016401168
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1111/j.1399-3011.1997.tb01200.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005092346
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1111/j.1749-6632.2000.tb06949.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016991642
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1136/jcp.49.11.952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036373153
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1159/000049168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021181735
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1200/jco.1999.17.2.615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074265662
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1200/jco.2000.18.6.1331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074604334
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1210/edrv-12-4-450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064237961
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1210/endo.140.11.7126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064282769
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1210/er.2000-0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051437649
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1378/chest.117.5.1232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005872047
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.2174/1381612033391621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069164803
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.3322/canjclin.43.1.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048602968
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.3892/ijo.9.3.445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071517872
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.7326/0003-4819-125-1-199607010-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073700529
    454 rdf:type schema:CreativeWork
    455 https://www.grid.ac/institutes/grid.208078.5 schema:alternateName University of Connecticut Health Center
    456 schema:name Department of Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington, Connecticut, USA
    457 Division of Nuclear Medicine MC-2804, University of Connecticut Health Center, 263 Farmington Ave, 06030-2804, Farmington, CT, USA
    458 rdf:type schema:Organization
    459 https://www.grid.ac/institutes/grid.412726.4 schema:alternateName Thomas Jefferson University Hospital
    460 schema:name Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA
    461 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...