Potential of Anti-Interleukin-2 Receptor Monoclonal Antibodies in Solid Organ Transplantation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

Teun van Gelder, Willem Weimar

ABSTRACT

Monoclonal and polyclonal antibody preparations have been used for induction therapy after organ transplantation. Apart from serious adverse effects directly associated with their administration, for example the cytokine release syndrome, the resulting profound and aspecific immunosuppression leads to increased incidences of infections and, in the long term, of malignancies. To avoid the drawbacks of this aselective immunosuppression, monoclonal antibodies (mAbs) against specific T cell activation determinants have been developed. In view of the pivotal role of interleukin-2 in the activation cascade of antigen-stimulated lymphocytes, mAbs directed against the interleukin-2 receptor (IL-2R) are believed to have a strong inhibitory effect only on activated T cells. The use of anti-IL-2R mAbs as prophylaxis against rejection after solid organ transplantation is well tolerated and does not lead to an increased incidence of infectious complications. The efficacy of these agents in kidney transplantation has now been demonstrated in several studies. In liver transplantation, considerable differences have been reported between the results obtained with different anti-IL-2R mAbs; in the prophylaxis of rejection, inolimomab (BT-563) was the most effective agent. In human cardiac transplantation, inolimomab seems to be as effective as muromonab-CD3 (OKT3) in preventing acute rejection, although rejection episodes tend to occur a little earlier with inolimomab. As shown by studies in kidney and liver transplantation, combination of anti-IL-2R mAb with cyclosporin administered from the day of transplantation appears to be the most effective strategy. Humanised anti-IL-2R mAbs are markedly less immunogenic and have improved pharmacokinetics, with prolonged terminal half-lives in vivo. Whether this leads to equal or improved efficacy and safety remains to be proven. The long half-life of humanised antibodies may potentially lead to prolonged coating of the IL-2R and over-immunosuppression. More... »

PAGES

46-55

Journal

TITLE

BioDrugs

ISSUE

1

VOLUME

8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00063030-199708010-00006

DOI

http://dx.doi.org/10.2165/00063030-199708010-00006

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025815442


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Department of Internal Medicine I, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Gelder", 
        "givenName": "Teun", 
        "id": "sg:person.01245157514.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245157514.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Erasmus University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5645.2", 
          "name": [
            "Department of Internal Medicine I, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weimar", 
        "givenName": "Willem", 
        "id": "sg:person.01132463171.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132463171.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00007890-198904000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001976887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198904000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001976887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199012203232502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002398937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199511150-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002657136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199511150-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002657136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199109000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003026524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199109000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003026524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.160.4.1126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003283969"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199303000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003393978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199303000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003393978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199303000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003393978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199007000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004217574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199007000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004217574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01788907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004229367", 
          "https://doi.org/10.1007/bf01788907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01788907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004229367", 
          "https://doi.org/10.1007/bf01788907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01788907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004229367", 
          "https://doi.org/10.1007/bf01788907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.90.6.2428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007236839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198512000-00029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008115390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198512000-00029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008115390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.5.1463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015301328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/302305a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016067322", 
          "https://doi.org/10.1038/302305a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90152-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016163477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198905253202117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017503307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.1994.tb06083.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018158033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199401001-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018292397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199401001-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018292397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(81)90024-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019462435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0161-5890(81)90024-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019462435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199401001-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020398113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199401001-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020398113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199401001-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020398113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199306000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020637371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199306000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020637371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199306000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020637371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.88.7.2663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021906651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199205000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023777056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199205000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023777056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199205000-00020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023777056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199006000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024680392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199006000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024680392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90167-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024698434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0966-3274(95)80026-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025497282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/300267a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026066237", 
          "https://doi.org/10.1038/300267a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.83.8.2624", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027062539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-1229(85)90035-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027349301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.158.6.1895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027955565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199203000-00038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030194090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199203000-00038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030194090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199508000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031458802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199508000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031458802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0952-7915(89)90170-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031622901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0952-7915(89)90170-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031622901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-2277.1994.tb01442.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034703391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199510150-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035946931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199510150-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035946931"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199001000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041829876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199001000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041829876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198605000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043238878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198605000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043238878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199008000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043479737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199008000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043479737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(87)90038-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044136997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0198-8859(87)90038-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044136997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044767151", 
          "https://doi.org/10.1038/ki.1994.306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1990.tb40479.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045883669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199101000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047417303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199101000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047417303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830170706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047914978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(92)90106-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048843855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0306-4522(92)90106-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048843855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199004263221702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049575908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.176.5.1265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049686327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050067811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050067811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199301000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052248524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199301000-00021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052248524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198903000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052661414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-198903000-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052661414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199412150-00029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053300267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199412150-00029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053300267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053451153", 
          "https://doi.org/10.1038/ki.1992.396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199602270-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605150-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605150-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199605150-00022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199607150-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199607150-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199607150-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060275976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199701150-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199701150-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007890-199701150-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060276364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.181845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062508258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2785715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062559093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3116668", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062591690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-116-2-148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073696283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076336027", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/tri.1992.5.s1.168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076598768"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076942814", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077979432", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077980973", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077980974", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077983284", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077983486", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078300954", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078356914", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078562304", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079198185", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079538017", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079538461", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079569874", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079569875", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079569876", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079779827", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082510116", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082547447", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082547854", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082547867", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082570156", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082601839", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082626624", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082629445", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082806769", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082806840", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082823209", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082827217", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-07", 
    "datePublishedReg": "1997-07-01", 
    "description": "Monoclonal and polyclonal antibody preparations have been used for induction therapy after organ transplantation. Apart from serious adverse effects directly associated with their administration, for example the cytokine release syndrome, the resulting profound and aspecific immunosuppression leads to increased incidences of infections and, in the long term, of malignancies. To avoid the drawbacks of this aselective immunosuppression, monoclonal antibodies (mAbs) against specific T cell activation determinants have been developed. In view of the pivotal role of interleukin-2 in the activation cascade of antigen-stimulated lymphocytes, mAbs directed against the interleukin-2 receptor (IL-2R) are believed to have a strong inhibitory effect only on activated T cells. The use of anti-IL-2R mAbs as prophylaxis against rejection after solid organ transplantation is well tolerated and does not lead to an increased incidence of infectious complications. The efficacy of these agents in kidney transplantation has now been demonstrated in several studies. In liver transplantation, considerable differences have been reported between the results obtained with different anti-IL-2R mAbs; in the prophylaxis of rejection, inolimomab (BT-563) was the most effective agent. In human cardiac transplantation, inolimomab seems to be as effective as muromonab-CD3 (OKT3) in preventing acute rejection, although rejection episodes tend to occur a little earlier with inolimomab. As shown by studies in kidney and liver transplantation, combination of anti-IL-2R mAb with cyclosporin administered from the day of transplantation appears to be the most effective strategy. Humanised anti-IL-2R mAbs are markedly less immunogenic and have improved pharmacokinetics, with prolonged terminal half-lives in vivo. Whether this leads to equal or improved efficacy and safety remains to be proven. The long half-life of humanised antibodies may potentially lead to prolonged coating of the IL-2R and over-immunosuppression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2165/00063030-199708010-00006", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1111842", 
        "issn": [
          "1173-8804", 
          "1179-190X"
        ], 
        "name": "BioDrugs", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Potential of Anti-Interleukin-2 Receptor Monoclonal Antibodies in Solid Organ Transplantation", 
    "pagination": "46-55", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7afd7a4a7ebcadae9a54f6bc660758c2021601c0ae8a61df7bf977b84fe40043"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2165/00063030-199708010-00006"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025815442"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2165/00063030-199708010-00006", 
      "https://app.dimensions.ai/details/publication/pub.1025815442"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000505.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.2165/00063030-199708010-00006"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/00063030-199708010-00006'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/00063030-199708010-00006'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/00063030-199708010-00006'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/00063030-199708010-00006'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      21 PREDICATES      114 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2165/00063030-199708010-00006 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nbfdf3adf263b45c7b7d96a4df0214b43
4 schema:citation sg:pub.10.1007/bf01788907
5 sg:pub.10.1038/300267a0
6 sg:pub.10.1038/302305a0
7 sg:pub.10.1038/ki.1992.396
8 sg:pub.10.1038/ki.1994.306
9 https://app.dimensions.ai/details/publication/pub.1076336027
10 https://app.dimensions.ai/details/publication/pub.1076942814
11 https://app.dimensions.ai/details/publication/pub.1077979432
12 https://app.dimensions.ai/details/publication/pub.1077980973
13 https://app.dimensions.ai/details/publication/pub.1077980974
14 https://app.dimensions.ai/details/publication/pub.1077983284
15 https://app.dimensions.ai/details/publication/pub.1077983486
16 https://app.dimensions.ai/details/publication/pub.1078300954
17 https://app.dimensions.ai/details/publication/pub.1078356914
18 https://app.dimensions.ai/details/publication/pub.1078562304
19 https://app.dimensions.ai/details/publication/pub.1079198185
20 https://app.dimensions.ai/details/publication/pub.1079538017
21 https://app.dimensions.ai/details/publication/pub.1079538461
22 https://app.dimensions.ai/details/publication/pub.1079569874
23 https://app.dimensions.ai/details/publication/pub.1079569875
24 https://app.dimensions.ai/details/publication/pub.1079569876
25 https://app.dimensions.ai/details/publication/pub.1079779827
26 https://app.dimensions.ai/details/publication/pub.1082510116
27 https://app.dimensions.ai/details/publication/pub.1082547447
28 https://app.dimensions.ai/details/publication/pub.1082547854
29 https://app.dimensions.ai/details/publication/pub.1082547867
30 https://app.dimensions.ai/details/publication/pub.1082570156
31 https://app.dimensions.ai/details/publication/pub.1082601839
32 https://app.dimensions.ai/details/publication/pub.1082626624
33 https://app.dimensions.ai/details/publication/pub.1082629445
34 https://app.dimensions.ai/details/publication/pub.1082806769
35 https://app.dimensions.ai/details/publication/pub.1082806840
36 https://app.dimensions.ai/details/publication/pub.1082823209
37 https://app.dimensions.ai/details/publication/pub.1082827217
38 https://doi.org/10.1002/eji.1830170706
39 https://doi.org/10.1016/0090-1229(85)90035-2
40 https://doi.org/10.1016/0092-8674(93)90152-g
41 https://doi.org/10.1016/0092-8674(93)90167-o
42 https://doi.org/10.1016/0161-5890(81)90024-9
43 https://doi.org/10.1016/0198-8859(87)90038-3
44 https://doi.org/10.1016/0306-4522(92)90106-c
45 https://doi.org/10.1016/0952-7915(89)90170-2
46 https://doi.org/10.1016/0966-3274(95)80026-3
47 https://doi.org/10.1056/nejm198905253202117
48 https://doi.org/10.1056/nejm199004263221702
49 https://doi.org/10.1056/nejm199012203232502
50 https://doi.org/10.1073/pnas.83.5.1463
51 https://doi.org/10.1073/pnas.83.8.2624
52 https://doi.org/10.1073/pnas.88.7.2663
53 https://doi.org/10.1073/pnas.90.6.2428
54 https://doi.org/10.1084/jem.158.6.1895
55 https://doi.org/10.1084/jem.160.4.1126
56 https://doi.org/10.1084/jem.176.5.1265
57 https://doi.org/10.1097/00007890-198512000-00029
58 https://doi.org/10.1097/00007890-198605000-00004
59 https://doi.org/10.1097/00007890-198903000-00011
60 https://doi.org/10.1097/00007890-198904000-00008
61 https://doi.org/10.1097/00007890-199001000-00010
62 https://doi.org/10.1097/00007890-199006000-00019
63 https://doi.org/10.1097/00007890-199007000-00010
64 https://doi.org/10.1097/00007890-199008000-00013
65 https://doi.org/10.1097/00007890-199101000-00016
66 https://doi.org/10.1097/00007890-199109000-00008
67 https://doi.org/10.1097/00007890-199203000-00038
68 https://doi.org/10.1097/00007890-199205000-00020
69 https://doi.org/10.1097/00007890-199301000-00021
70 https://doi.org/10.1097/00007890-199303000-00016
71 https://doi.org/10.1097/00007890-199304000-00013
72 https://doi.org/10.1097/00007890-199306000-00021
73 https://doi.org/10.1097/00007890-199401001-00007
74 https://doi.org/10.1097/00007890-199401001-00008
75 https://doi.org/10.1097/00007890-199412150-00029
76 https://doi.org/10.1097/00007890-199508000-00007
77 https://doi.org/10.1097/00007890-199510150-00023
78 https://doi.org/10.1097/00007890-199511150-00010
79 https://doi.org/10.1097/00007890-199602270-00006
80 https://doi.org/10.1097/00007890-199605150-00022
81 https://doi.org/10.1097/00007890-199607150-00011
82 https://doi.org/10.1097/00007890-199701150-00007
83 https://doi.org/10.1111/j.1365-2249.1994.tb06083.x
84 https://doi.org/10.1111/j.1432-2277.1994.tb01442.x
85 https://doi.org/10.1111/j.1749-6632.1990.tb40479.x
86 https://doi.org/10.1111/tri.1992.5.s1.168
87 https://doi.org/10.1126/science.181845
88 https://doi.org/10.1126/science.2785715
89 https://doi.org/10.1126/science.3116668
90 https://doi.org/10.7326/0003-4819-116-2-148
91 schema:datePublished 1997-07
92 schema:datePublishedReg 1997-07-01
93 schema:description Monoclonal and polyclonal antibody preparations have been used for induction therapy after organ transplantation. Apart from serious adverse effects directly associated with their administration, for example the cytokine release syndrome, the resulting profound and aspecific immunosuppression leads to increased incidences of infections and, in the long term, of malignancies. To avoid the drawbacks of this aselective immunosuppression, monoclonal antibodies (mAbs) against specific T cell activation determinants have been developed. In view of the pivotal role of interleukin-2 in the activation cascade of antigen-stimulated lymphocytes, mAbs directed against the interleukin-2 receptor (IL-2R) are believed to have a strong inhibitory effect only on activated T cells. The use of anti-IL-2R mAbs as prophylaxis against rejection after solid organ transplantation is well tolerated and does not lead to an increased incidence of infectious complications. The efficacy of these agents in kidney transplantation has now been demonstrated in several studies. In liver transplantation, considerable differences have been reported between the results obtained with different anti-IL-2R mAbs; in the prophylaxis of rejection, inolimomab (BT-563) was the most effective agent. In human cardiac transplantation, inolimomab seems to be as effective as muromonab-CD3 (OKT3) in preventing acute rejection, although rejection episodes tend to occur a little earlier with inolimomab. As shown by studies in kidney and liver transplantation, combination of anti-IL-2R mAb with cyclosporin administered from the day of transplantation appears to be the most effective strategy. Humanised anti-IL-2R mAbs are markedly less immunogenic and have improved pharmacokinetics, with prolonged terminal half-lives in vivo. Whether this leads to equal or improved efficacy and safety remains to be proven. The long half-life of humanised antibodies may potentially lead to prolonged coating of the IL-2R and over-immunosuppression.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree false
97 schema:isPartOf N0eda603439cb4bbf948cec85835c5c49
98 N70c4cf8525d14f318f774f9693eaedf5
99 sg:journal.1111842
100 schema:name Potential of Anti-Interleukin-2 Receptor Monoclonal Antibodies in Solid Organ Transplantation
101 schema:pagination 46-55
102 schema:productId N4343815f01154e0a9f5ea43f4a7f0de6
103 N4a7b6f9bc4f646eaa4c500d58e7f3b45
104 Nfef2075fa286413589caa38ca7be31a4
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025815442
106 https://doi.org/10.2165/00063030-199708010-00006
107 schema:sdDatePublished 2019-04-10T20:45
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher Neec4df403ce8499795b7e105f6a15b4d
110 schema:url http://link.springer.com/10.2165/00063030-199708010-00006
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N0eda603439cb4bbf948cec85835c5c49 schema:issueNumber 1
115 rdf:type schema:PublicationIssue
116 N4343815f01154e0a9f5ea43f4a7f0de6 schema:name dimensions_id
117 schema:value pub.1025815442
118 rdf:type schema:PropertyValue
119 N4a7b6f9bc4f646eaa4c500d58e7f3b45 schema:name readcube_id
120 schema:value 7afd7a4a7ebcadae9a54f6bc660758c2021601c0ae8a61df7bf977b84fe40043
121 rdf:type schema:PropertyValue
122 N4feafb1257414c72959451e7d6b0f61b rdf:first sg:person.01132463171.53
123 rdf:rest rdf:nil
124 N70c4cf8525d14f318f774f9693eaedf5 schema:volumeNumber 8
125 rdf:type schema:PublicationVolume
126 Nbfdf3adf263b45c7b7d96a4df0214b43 rdf:first sg:person.01245157514.17
127 rdf:rest N4feafb1257414c72959451e7d6b0f61b
128 Neec4df403ce8499795b7e105f6a15b4d schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 Nfef2075fa286413589caa38ca7be31a4 schema:name doi
131 schema:value 10.2165/00063030-199708010-00006
132 rdf:type schema:PropertyValue
133 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
134 schema:name Medical and Health Sciences
135 rdf:type schema:DefinedTerm
136 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
137 schema:name Immunology
138 rdf:type schema:DefinedTerm
139 sg:journal.1111842 schema:issn 1173-8804
140 1179-190X
141 schema:name BioDrugs
142 rdf:type schema:Periodical
143 sg:person.01132463171.53 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
144 schema:familyName Weimar
145 schema:givenName Willem
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132463171.53
147 rdf:type schema:Person
148 sg:person.01245157514.17 schema:affiliation https://www.grid.ac/institutes/grid.5645.2
149 schema:familyName van Gelder
150 schema:givenName Teun
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245157514.17
152 rdf:type schema:Person
153 sg:pub.10.1007/bf01788907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004229367
154 https://doi.org/10.1007/bf01788907
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/300267a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026066237
157 https://doi.org/10.1038/300267a0
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/302305a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016067322
160 https://doi.org/10.1038/302305a0
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/ki.1992.396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053451153
163 https://doi.org/10.1038/ki.1992.396
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/ki.1994.306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044767151
166 https://doi.org/10.1038/ki.1994.306
167 rdf:type schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1076336027 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1076942814 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1077979432 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1077980973 schema:CreativeWork
172 https://app.dimensions.ai/details/publication/pub.1077980974 schema:CreativeWork
173 https://app.dimensions.ai/details/publication/pub.1077983284 schema:CreativeWork
174 https://app.dimensions.ai/details/publication/pub.1077983486 schema:CreativeWork
175 https://app.dimensions.ai/details/publication/pub.1078300954 schema:CreativeWork
176 https://app.dimensions.ai/details/publication/pub.1078356914 schema:CreativeWork
177 https://app.dimensions.ai/details/publication/pub.1078562304 schema:CreativeWork
178 https://app.dimensions.ai/details/publication/pub.1079198185 schema:CreativeWork
179 https://app.dimensions.ai/details/publication/pub.1079538017 schema:CreativeWork
180 https://app.dimensions.ai/details/publication/pub.1079538461 schema:CreativeWork
181 https://app.dimensions.ai/details/publication/pub.1079569874 schema:CreativeWork
182 https://app.dimensions.ai/details/publication/pub.1079569875 schema:CreativeWork
183 https://app.dimensions.ai/details/publication/pub.1079569876 schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1079779827 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1082510116 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1082547447 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1082547854 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1082547867 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1082570156 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1082601839 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1082626624 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1082629445 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1082806769 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1082806840 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1082823209 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1082827217 schema:CreativeWork
197 https://doi.org/10.1002/eji.1830170706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047914978
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/0090-1229(85)90035-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027349301
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/0092-8674(93)90152-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1016163477
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0092-8674(93)90167-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1024698434
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0161-5890(81)90024-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019462435
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/0198-8859(87)90038-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044136997
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/0306-4522(92)90106-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1048843855
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0952-7915(89)90170-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031622901
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0966-3274(95)80026-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025497282
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejm198905253202117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017503307
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1056/nejm199004263221702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049575908
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1056/nejm199012203232502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002398937
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.83.5.1463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015301328
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.83.8.2624 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027062539
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.88.7.2663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021906651
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1073/pnas.90.6.2428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007236839
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1084/jem.158.6.1895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027955565
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1084/jem.160.4.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003283969
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1084/jem.176.5.1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049686327
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/00007890-198512000-00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008115390
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/00007890-198605000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043238878
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1097/00007890-198903000-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052661414
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1097/00007890-198904000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001976887
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1097/00007890-199001000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041829876
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1097/00007890-199006000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024680392
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1097/00007890-199007000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004217574
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1097/00007890-199008000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043479737
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1097/00007890-199101000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047417303
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1097/00007890-199109000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003026524
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1097/00007890-199203000-00038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030194090
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1097/00007890-199205000-00020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023777056
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1097/00007890-199301000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052248524
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/00007890-199303000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003393978
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1097/00007890-199304000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050067811
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1097/00007890-199306000-00021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020637371
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1097/00007890-199401001-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020398113
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00007890-199401001-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018292397
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1097/00007890-199412150-00029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053300267
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1097/00007890-199508000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031458802
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/00007890-199510150-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035946931
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1097/00007890-199511150-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002657136
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1097/00007890-199602270-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275710
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1097/00007890-199605150-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275881
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1097/00007890-199607150-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060275976
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1097/00007890-199701150-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060276364
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1111/j.1365-2249.1994.tb06083.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018158033
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1111/j.1432-2277.1994.tb01442.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034703391
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1111/j.1749-6632.1990.tb40479.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045883669
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1111/tri.1992.5.s1.168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076598768
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1126/science.181845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062508258
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1126/science.2785715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559093
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1126/science.3116668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062591690
300 rdf:type schema:CreativeWork
301 https://doi.org/10.7326/0003-4819-116-2-148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073696283
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.5645.2 schema:alternateName Erasmus University Medical Center
304 schema:name Department of Internal Medicine I, University Hospital Rotterdam-Dijkzigt, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...