Efficacy and Tolerability of Candesartan Cilexetil Monotherapy or in Combination with Other Antihypertensive Drugs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-12

AUTHORS

K. -L. Schulte, M. Fischer, T. Lenz, W. Meyer-Sabellek

ABSTRACT

Objective: To evaluate the efficacy and tolerability of different dosages of candesartan cilexetil administered as monotherapy or in combination with any pre-existing but insufficient antihypertensive treatment. The effects of candesartan cilexetil treatment on quality of life were also investigated. Design and Setting: This was an open, multicentre, nonrandomised study conducted at 1575 centres throughout Germany. Patients: 4531 patients with primary hypertension receiving no or insufficient antihypertensive treatment [diastolic blood pressure (DBP) >95mm Hg] participated in the study. Interventions: Patients received candesartan cilexetil 8mg once daily in addition to any pre-existing antihypertensive therapy. The dosage was increased to 16mg after 4 weeks and to 32mg after 8 weeks if sitting clinic DBP remained ≥90mm Hg. Results: Candesartan cilexetil (mean dose 14.8mg) reduced mean sitting DBP and systolic blood pressure by 16 (from 102 to 86mm Hg) and 26mm Hg (from 172 to 145mm Hg), respectively. Blood pressure control (DBP<90mm Hg) was achieved in 67.8% of patients by week 12. The mean Psychological General Well-Being index was improved by 9.2 units. Candesartan cilexetil was well tolerated with only 6.1% of patients reporting an adverse event. Conclusions: This study demonstrates that treatment with candesartan cilexetil is efficacious and well tolerated in patients with mild to moderate primary hypertension. The efficacy of candesartan cilexetil is independent of antihypertensive co-medication, achieving a DBP close to 85mm Hg in most patients. More... »

PAGES

453-460

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00044011-199918060-00004

DOI

http://dx.doi.org/10.2165/00044011-199918060-00004

DIMENSIONS

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