A Model of Long-term Metabolic Progression of Type 2 Diabetes Mellitus for Evaluating Treatment Strategies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-11

AUTHORS

Adrian Bagust, Marc Evans, Sophie Beale, Philip D. Home, Andrew S. Perry, Murray Stewart

ABSTRACT

AIM: To develop a novel metabolic computer model of the natural lifetime progression of type 2 diabetes that generates dynamic risk factor trajectories consistent with prespecified lifetime therapeutic strategies, in order to enhance the long-term economic and outcome modelling of type 2 diabetes and its complications. METHODS: The main model drivers of progressive disease were changes in insulin sensitivity and islet beta-cell function derived from an analysis of follow-up results from the Belfast Diet Study. These were related to clinical measures through an adaptation of the homeostasis model assessment. Established causal relationships estimating body mass index, lipids and blood pressure from measures of glycaemia and plasma insulin were calibrated using Third National Health and Nutrition Examination Survey (USA) data, standardizing for age, sex, ethnicity and smoking. The effects of individual interventions were calibrated using published trial evidence, in line with the current understanding of the main modes of action of each agent. RESULTS: A comparison of the effects of common therapies using the model showed both similarities and differences. Large improvements in glycaemic control from lifestyle modifications, further enhanced by oral glucose-lowering drugs or insulin, were reproduced. Projections comparing lifetime therapeutic strategies suggest that simple guidelines may not always be valid. CONCLUSION: This novel mathematical model using evidence from the long-term natural history of type 2 diabetes is able to project the expected effects of various antihyperglycaemic therapies. Coupled with an economic model, this metabolic model may provide a mechanism for healthcare professionals and policymakers to evaluate different long-term strategies for the management of type 2 diabetes. More... »

PAGES

5-19

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00019053-200624001-00002

DOI

http://dx.doi.org/10.2165/00019053-200624001-00002

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052794248

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16800159


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evaluation Studies as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeostasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Least-Squares Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Life Style", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Theoretical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nutrition Surveys", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Liverpool", 
          "id": "https://www.grid.ac/institutes/grid.10025.36", 
          "name": [
            "University of Liverpool Management School, Chatham Street, L69 7ZH, Liverpool, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bagust", 
        "givenName": "Adrian", 
        "id": "sg:person.0734730102.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734730102.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Wales", 
          "id": "https://www.grid.ac/institutes/grid.241103.5", 
          "name": [
            "Department of Medicine, University Hospital of Wales, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evans", 
        "givenName": "Marc", 
        "id": "sg:person.01167546340.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167546340.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of York", 
          "id": "https://www.grid.ac/institutes/grid.5685.e", 
          "name": [
            "York Health Economics Consortium, University of York, York, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beale", 
        "givenName": "Sophie", 
        "id": "sg:person.01304262307.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304262307.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Newcastle, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Home", 
        "givenName": "Philip D.", 
        "id": "sg:person.01002541711.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002541711.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United States)", 
          "id": "https://www.grid.ac/institutes/grid.418019.5", 
          "name": [
            "GlaxoSmithKline Research and Development, Philadelphia, PA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perry", 
        "givenName": "Andrew S.", 
        "id": "sg:person.01123315273.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123315273.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GlaxoSmithKline (United Kingdom)", 
          "id": "https://www.grid.ac/institutes/grid.418236.a", 
          "name": [
            "GlaxoSmithKline Research and Development, Harlow, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stewart", 
        "givenName": "Murray", 
        "id": "sg:person.0642120435.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642120435.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s001250100023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000221893", 
          "https://doi.org/10.1007/s001250100023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250100023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000221893", 
          "https://doi.org/10.1007/s001250100023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-5491.2003.00889.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000634415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199309303291401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004144761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00019053-200624001-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004759611", 
          "https://doi.org/10.2165/00019053-200624001-00003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(97)00254-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005252023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.11.3093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006292806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2362.2000.00735.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006561928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-0495(95)90153-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006865870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0026-0495(98)90281-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013003601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013310140", 
          "https://doi.org/10.1007/s001250050005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013310140", 
          "https://doi.org/10.1007/s001250050005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-0495(89)90129-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015417802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-6175.2002.00499.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015993379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-6175.2002.00499.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015993379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(00)00338-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017553419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)07019-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018881858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2002.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020868976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.25.7.1247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022299524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.317.7160.703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022997249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.11.3102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026282993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.34.6.1281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027076562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0026-0495(90)90299-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028113543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.25.7.1177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031040209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-2977(98)00145-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031344930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199508313330902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032415571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041433-199910000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036038800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00041433-199910000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036038800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9136(199804)15:4<290::aid-dia570>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036259713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1527-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036304902", 
          "https://doi.org/10.1007/s00125-004-1527-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-004-1527-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036304902", 
          "https://doi.org/10.1007/s00125-004-1527-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1464-5491.1999.00171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036751811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0010-4825(97)83147-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036812542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037260692", 
          "https://doi.org/10.1007/s001250050643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s001250050643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037260692", 
          "https://doi.org/10.1007/s001250050643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(00)00215-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037777899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.3.5978.276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037963566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.303.6805.755", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040724156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.162.21.2428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041326011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1532-0464(02)00006-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041829715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(99)00132-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041943590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(00)00216-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046067547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(02)01717-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048292263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.24.7.1167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049633436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.160.9.1321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050731197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1996.03540170053032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050802411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051391086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1345/aph.1a061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051391086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199604113341504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052104609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.28.2.500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052772978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.276.17.1409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054160246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt196232191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054352887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cs20000335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056719025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6972.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062770608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.310.6972.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062770608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.86.9.4047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064302087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.9.7713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.44.11.1249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070742916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.17.1.45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070746164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.17.10.1100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070746175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.19.8.849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.20.5.725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.20.5.735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070747684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.21.12.2191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070748075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-137-1-200207020-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073705509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075011777", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080284174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532132", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082780253", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1997.273.2.e425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083138165"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-11", 
    "datePublishedReg": "2006-11-01", 
    "description": "AIM: To develop a novel metabolic computer model of the natural lifetime progression of type 2 diabetes that generates dynamic risk factor trajectories consistent with prespecified lifetime therapeutic strategies, in order to enhance the long-term economic and outcome modelling of type 2 diabetes and its complications.\nMETHODS: The main model drivers of progressive disease were changes in insulin sensitivity and islet beta-cell function derived from an analysis of follow-up results from the Belfast Diet Study. These were related to clinical measures through an adaptation of the homeostasis model assessment. Established causal relationships estimating body mass index, lipids and blood pressure from measures of glycaemia and plasma insulin were calibrated using Third National Health and Nutrition Examination Survey (USA) data, standardizing for age, sex, ethnicity and smoking. The effects of individual interventions were calibrated using published trial evidence, in line with the current understanding of the main modes of action of each agent.\nRESULTS: A comparison of the effects of common therapies using the model showed both similarities and differences. Large improvements in glycaemic control from lifestyle modifications, further enhanced by oral glucose-lowering drugs or insulin, were reproduced. Projections comparing lifetime therapeutic strategies suggest that simple guidelines may not always be valid.\nCONCLUSION: This novel mathematical model using evidence from the long-term natural history of type 2 diabetes is able to project the expected effects of various antihyperglycaemic therapies. Coupled with an economic model, this metabolic model may provide a mechanism for healthcare professionals and policymakers to evaluate different long-term strategies for the management of type 2 diabetes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2165/00019053-200624001-00002", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102812", 
        "issn": [
          "1170-7690", 
          "1179-2027"
        ], 
        "name": "PharmacoEconomics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "A Model of Long-term Metabolic Progression of Type 2 Diabetes Mellitus for Evaluating Treatment Strategies", 
    "pagination": "5-19", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fb79897c9ae90895a71b03d8fe2245d691de6b6ffdb3c60e5b9e8203630eda5f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16800159"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9212404"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2165/00019053-200624001-00002"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052794248"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2165/00019053-200624001-00002", 
      "https://app.dimensions.ai/details/publication/pub.1052794248"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000596.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.2165/00019053-200624001-00002"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/00019053-200624001-00002'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/00019053-200624001-00002'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/00019053-200624001-00002'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/00019053-200624001-00002'


 

This table displays all metadata directly associated to this object as RDF triples.

362 TRIPLES      21 PREDICATES      105 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2165/00019053-200624001-00002 schema:about N07f6a67e3e8242a19123ded9c9ccd0ce
2 N1fe25d8dfa094e3583171ec10d60c171
3 N22925fe4672a47a4a76cde636a1118d3
4 N2ef9fe83a862446f851d45ca2bd9cb9e
5 N372bf68d024f4b32a4183e39a00ee14f
6 N7ca82ed9d52b4cb7bf31c32d7171ff74
7 Na21efbf2d14941e3bc803df6a763db45
8 Na3b19a4575364cc68b6394f3a89ac528
9 Na77903e00eac4ca4a4bf94fba2ca9d02
10 Nb82ae7c32fd34376b3e21ecb1f45a7a9
11 Nc8d317ff36a94a23a26b35c4989efd7d
12 Ndc14dadc20e944aa8a5a929d58e97d75
13 Ne275eaeae9f347f0a18e20f451fb9966
14 Ne9cb38dd85084172a3102104bc4935a2
15 anzsrc-for:11
16 anzsrc-for:1103
17 schema:author N6d89e68730b74ddfb648d465edea7026
18 schema:citation sg:pub.10.1007/s00125-004-1527-z
19 sg:pub.10.1007/s001250050005
20 sg:pub.10.1007/s001250050643
21 sg:pub.10.1007/s001250100023
22 sg:pub.10.2165/00019053-200624001-00003
23 https://app.dimensions.ai/details/publication/pub.1075011777
24 https://app.dimensions.ai/details/publication/pub.1080284174
25 https://app.dimensions.ai/details/publication/pub.1082532132
26 https://app.dimensions.ai/details/publication/pub.1082780253
27 https://doi.org/10.1001/archinte.160.9.1321
28 https://doi.org/10.1001/archinte.162.21.2428
29 https://doi.org/10.1001/jama.1996.03540170053032
30 https://doi.org/10.1001/jama.276.17.1409
31 https://doi.org/10.1002/(sici)1096-9136(199804)15:4<290::aid-dia570>3.0.co;2-m
32 https://doi.org/10.1002/cpt196232191
33 https://doi.org/10.1016/0026-0495(89)90129-7
34 https://doi.org/10.1016/0026-0495(90)90299-r
35 https://doi.org/10.1016/0026-0495(95)90153-1
36 https://doi.org/10.1016/s0002-9149(99)00132-0
37 https://doi.org/10.1016/s0002-9343(00)00338-7
38 https://doi.org/10.1016/s0002-9343(97)00254-4
39 https://doi.org/10.1016/s0010-4825(97)83147-2
40 https://doi.org/10.1016/s0026-0495(98)90281-5
41 https://doi.org/10.1016/s0140-6736(98)07019-6
42 https://doi.org/10.1016/s0168-8227(00)00215-1
43 https://doi.org/10.1016/s0168-8227(00)00216-3
44 https://doi.org/10.1016/s0300-2977(98)00145-4
45 https://doi.org/10.1016/s0735-1097(02)01717-5
46 https://doi.org/10.1016/s1532-0464(02)00006-0
47 https://doi.org/10.1038/oby.2002.124
48 https://doi.org/10.1042/cs20000335
49 https://doi.org/10.1046/j.1365-2362.2000.00735.x
50 https://doi.org/10.1046/j.1464-5491.1999.00171.x
51 https://doi.org/10.1046/j.1464-5491.2003.00889.x
52 https://doi.org/10.1056/nejm199309303291401
53 https://doi.org/10.1056/nejm199508313330902
54 https://doi.org/10.1056/nejm199604113341504
55 https://doi.org/10.1097/00041433-199910000-00002
56 https://doi.org/10.1111/j.1524-6175.2002.00499.x
57 https://doi.org/10.1136/bmj.3.5978.276
58 https://doi.org/10.1136/bmj.303.6805.755
59 https://doi.org/10.1136/bmj.310.6972.83
60 https://doi.org/10.1136/bmj.317.7160.703
61 https://doi.org/10.1152/ajpendo.1997.273.2.e425
62 https://doi.org/10.1161/01.hyp.34.6.1281
63 https://doi.org/10.1210/jc.86.9.4047
64 https://doi.org/10.1210/jcem.86.9.7713
65 https://doi.org/10.1345/aph.1a061
66 https://doi.org/10.2337/diabetes.44.11.1249
67 https://doi.org/10.2337/diacare.17.1.45
68 https://doi.org/10.2337/diacare.17.10.1100
69 https://doi.org/10.2337/diacare.19.8.849
70 https://doi.org/10.2337/diacare.20.5.725
71 https://doi.org/10.2337/diacare.20.5.735
72 https://doi.org/10.2337/diacare.21.12.2191
73 https://doi.org/10.2337/diacare.24.7.1167
74 https://doi.org/10.2337/diacare.25.7.1177
75 https://doi.org/10.2337/diacare.25.7.1247
76 https://doi.org/10.2337/diacare.26.11.3093
77 https://doi.org/10.2337/diacare.26.11.3102
78 https://doi.org/10.2337/diacare.28.2.500
79 https://doi.org/10.7326/0003-4819-137-1-200207020-00009
80 schema:datePublished 2006-11
81 schema:datePublishedReg 2006-11-01
82 schema:description AIM: To develop a novel metabolic computer model of the natural lifetime progression of type 2 diabetes that generates dynamic risk factor trajectories consistent with prespecified lifetime therapeutic strategies, in order to enhance the long-term economic and outcome modelling of type 2 diabetes and its complications. METHODS: The main model drivers of progressive disease were changes in insulin sensitivity and islet beta-cell function derived from an analysis of follow-up results from the Belfast Diet Study. These were related to clinical measures through an adaptation of the homeostasis model assessment. Established causal relationships estimating body mass index, lipids and blood pressure from measures of glycaemia and plasma insulin were calibrated using Third National Health and Nutrition Examination Survey (USA) data, standardizing for age, sex, ethnicity and smoking. The effects of individual interventions were calibrated using published trial evidence, in line with the current understanding of the main modes of action of each agent. RESULTS: A comparison of the effects of common therapies using the model showed both similarities and differences. Large improvements in glycaemic control from lifestyle modifications, further enhanced by oral glucose-lowering drugs or insulin, were reproduced. Projections comparing lifetime therapeutic strategies suggest that simple guidelines may not always be valid. CONCLUSION: This novel mathematical model using evidence from the long-term natural history of type 2 diabetes is able to project the expected effects of various antihyperglycaemic therapies. Coupled with an economic model, this metabolic model may provide a mechanism for healthcare professionals and policymakers to evaluate different long-term strategies for the management of type 2 diabetes.
83 schema:genre research_article
84 schema:inLanguage en
85 schema:isAccessibleForFree false
86 schema:isPartOf N77b9371945db402ab8dbc1f00ced3878
87 N83ef4dbb2f35427d9301b2a245e0d587
88 sg:journal.1102812
89 schema:name A Model of Long-term Metabolic Progression of Type 2 Diabetes Mellitus for Evaluating Treatment Strategies
90 schema:pagination 5-19
91 schema:productId N0a2a65915f5c40c8a90a131a13aee884
92 N31095e4592354c2387f88d07c04c95a9
93 N3943cca41826449c8ee63fa2b173ba18
94 N4237210ae3b043bfb4292731319a4291
95 N4c51837ea2314d7881d3c4788301b5ab
96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052794248
97 https://doi.org/10.2165/00019053-200624001-00002
98 schema:sdDatePublished 2019-04-10T22:46
99 schema:sdLicense https://scigraph.springernature.com/explorer/license/
100 schema:sdPublisher N669881cf4d5540099885b5adb7121afa
101 schema:url http://link.springer.com/10.2165/00019053-200624001-00002
102 sgo:license sg:explorer/license/
103 sgo:sdDataset articles
104 rdf:type schema:ScholarlyArticle
105 N07f6a67e3e8242a19123ded9c9ccd0ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Nutrition Surveys
107 rdf:type schema:DefinedTerm
108 N0a2a65915f5c40c8a90a131a13aee884 schema:name nlm_unique_id
109 schema:value 9212404
110 rdf:type schema:PropertyValue
111 N1143b93bfe1043b69b786e129462bf0c rdf:first sg:person.0642120435.12
112 rdf:rest rdf:nil
113 N1fe25d8dfa094e3583171ec10d60c171 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Hypoglycemic Agents
115 rdf:type schema:DefinedTerm
116 N22925fe4672a47a4a76cde636a1118d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Life Style
118 rdf:type schema:DefinedTerm
119 N281240530e8d4427beb1c10a4c8786a3 rdf:first sg:person.01002541711.37
120 rdf:rest N966fab2e1e024e12a016050b15621a14
121 N2ef9fe83a862446f851d45ca2bd9cb9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Treatment Outcome
123 rdf:type schema:DefinedTerm
124 N31095e4592354c2387f88d07c04c95a9 schema:name doi
125 schema:value 10.2165/00019053-200624001-00002
126 rdf:type schema:PropertyValue
127 N372bf68d024f4b32a4183e39a00ee14f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Female
129 rdf:type schema:DefinedTerm
130 N3943cca41826449c8ee63fa2b173ba18 schema:name dimensions_id
131 schema:value pub.1052794248
132 rdf:type schema:PropertyValue
133 N4237210ae3b043bfb4292731319a4291 schema:name readcube_id
134 schema:value fb79897c9ae90895a71b03d8fe2245d691de6b6ffdb3c60e5b9e8203630eda5f
135 rdf:type schema:PropertyValue
136 N4c51837ea2314d7881d3c4788301b5ab schema:name pubmed_id
137 schema:value 16800159
138 rdf:type schema:PropertyValue
139 N669881cf4d5540099885b5adb7121afa schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N6d89e68730b74ddfb648d465edea7026 rdf:first sg:person.0734730102.33
142 rdf:rest N90bf0c7ed4064edb9fbf2d2ca6ba1387
143 N77b9371945db402ab8dbc1f00ced3878 schema:issueNumber Suppl 1
144 rdf:type schema:PublicationIssue
145 N7ca82ed9d52b4cb7bf31c32d7171ff74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Homeostasis
147 rdf:type schema:DefinedTerm
148 N83ef4dbb2f35427d9301b2a245e0d587 schema:volumeNumber 24
149 rdf:type schema:PublicationVolume
150 N90bf0c7ed4064edb9fbf2d2ca6ba1387 rdf:first sg:person.01167546340.80
151 rdf:rest Nc65e309fcd6b4a37b07384cd59b51394
152 N966fab2e1e024e12a016050b15621a14 rdf:first sg:person.01123315273.11
153 rdf:rest N1143b93bfe1043b69b786e129462bf0c
154 Na21efbf2d14941e3bc803df6a763db45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Evaluation Studies as Topic
156 rdf:type schema:DefinedTerm
157 Na3b19a4575364cc68b6394f3a89ac528 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Humans
159 rdf:type schema:DefinedTerm
160 Na77903e00eac4ca4a4bf94fba2ca9d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Blood Pressure
162 rdf:type schema:DefinedTerm
163 Nb82ae7c32fd34376b3e21ecb1f45a7a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Models, Biological
165 rdf:type schema:DefinedTerm
166 Nc65e309fcd6b4a37b07384cd59b51394 rdf:first sg:person.01304262307.87
167 rdf:rest N281240530e8d4427beb1c10a4c8786a3
168 Nc8d317ff36a94a23a26b35c4989efd7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 Ndc14dadc20e944aa8a5a929d58e97d75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Models, Theoretical
173 rdf:type schema:DefinedTerm
174 Ne275eaeae9f347f0a18e20f451fb9966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Diabetes Mellitus, Type 2
176 rdf:type schema:DefinedTerm
177 Ne9cb38dd85084172a3102104bc4935a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Least-Squares Analysis
179 rdf:type schema:DefinedTerm
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
184 schema:name Clinical Sciences
185 rdf:type schema:DefinedTerm
186 sg:journal.1102812 schema:issn 1170-7690
187 1179-2027
188 schema:name PharmacoEconomics
189 rdf:type schema:Periodical
190 sg:person.01002541711.37 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
191 schema:familyName Home
192 schema:givenName Philip D.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002541711.37
194 rdf:type schema:Person
195 sg:person.01123315273.11 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
196 schema:familyName Perry
197 schema:givenName Andrew S.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123315273.11
199 rdf:type schema:Person
200 sg:person.01167546340.80 schema:affiliation https://www.grid.ac/institutes/grid.241103.5
201 schema:familyName Evans
202 schema:givenName Marc
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167546340.80
204 rdf:type schema:Person
205 sg:person.01304262307.87 schema:affiliation https://www.grid.ac/institutes/grid.5685.e
206 schema:familyName Beale
207 schema:givenName Sophie
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304262307.87
209 rdf:type schema:Person
210 sg:person.0642120435.12 schema:affiliation https://www.grid.ac/institutes/grid.418236.a
211 schema:familyName Stewart
212 schema:givenName Murray
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642120435.12
214 rdf:type schema:Person
215 sg:person.0734730102.33 schema:affiliation https://www.grid.ac/institutes/grid.10025.36
216 schema:familyName Bagust
217 schema:givenName Adrian
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734730102.33
219 rdf:type schema:Person
220 sg:pub.10.1007/s00125-004-1527-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1036304902
221 https://doi.org/10.1007/s00125-004-1527-z
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s001250050005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013310140
224 https://doi.org/10.1007/s001250050005
225 rdf:type schema:CreativeWork
226 sg:pub.10.1007/s001250050643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037260692
227 https://doi.org/10.1007/s001250050643
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/s001250100023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000221893
230 https://doi.org/10.1007/s001250100023
231 rdf:type schema:CreativeWork
232 sg:pub.10.2165/00019053-200624001-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004759611
233 https://doi.org/10.2165/00019053-200624001-00003
234 rdf:type schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1075011777 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1080284174 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1082532132 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1082780253 schema:CreativeWork
239 https://doi.org/10.1001/archinte.160.9.1321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050731197
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1001/archinte.162.21.2428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041326011
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1001/jama.1996.03540170053032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050802411
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1001/jama.276.17.1409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054160246
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/(sici)1096-9136(199804)15:4<290::aid-dia570>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1036259713
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/cpt196232191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054352887
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0026-0495(89)90129-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015417802
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0026-0495(90)90299-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1028113543
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0026-0495(95)90153-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006865870
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0002-9149(99)00132-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041943590
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0002-9343(00)00338-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017553419
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0002-9343(97)00254-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005252023
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0010-4825(97)83147-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036812542
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0026-0495(98)90281-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013003601
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0140-6736(98)07019-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018881858
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0168-8227(00)00215-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037777899
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0168-8227(00)00216-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046067547
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0300-2977(98)00145-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031344930
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0735-1097(02)01717-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048292263
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s1532-0464(02)00006-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041829715
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1038/oby.2002.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020868976
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1042/cs20000335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056719025
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1046/j.1365-2362.2000.00735.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561928
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1464-5491.1999.00171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036751811
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1046/j.1464-5491.2003.00889.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000634415
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1056/nejm199309303291401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004144761
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1056/nejm199508313330902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032415571
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1056/nejm199604113341504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052104609
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/00041433-199910000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036038800
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1524-6175.2002.00499.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015993379
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1136/bmj.3.5978.276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037963566
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1136/bmj.303.6805.755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040724156
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1136/bmj.310.6972.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062770608
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1136/bmj.317.7160.703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022997249
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1152/ajpendo.1997.273.2.e425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083138165
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1161/01.hyp.34.6.1281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027076562
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1210/jc.86.9.4047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064302087
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1210/jcem.86.9.7713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324710
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1345/aph.1a061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051391086
316 rdf:type schema:CreativeWork
317 https://doi.org/10.2337/diabetes.44.11.1249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070742916
318 rdf:type schema:CreativeWork
319 https://doi.org/10.2337/diacare.17.1.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070746164
320 rdf:type schema:CreativeWork
321 https://doi.org/10.2337/diacare.17.10.1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070746175
322 rdf:type schema:CreativeWork
323 https://doi.org/10.2337/diacare.19.8.849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747211
324 rdf:type schema:CreativeWork
325 https://doi.org/10.2337/diacare.20.5.725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747683
326 rdf:type schema:CreativeWork
327 https://doi.org/10.2337/diacare.20.5.735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070747684
328 rdf:type schema:CreativeWork
329 https://doi.org/10.2337/diacare.21.12.2191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070748075
330 rdf:type schema:CreativeWork
331 https://doi.org/10.2337/diacare.24.7.1167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049633436
332 rdf:type schema:CreativeWork
333 https://doi.org/10.2337/diacare.25.7.1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031040209
334 rdf:type schema:CreativeWork
335 https://doi.org/10.2337/diacare.25.7.1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022299524
336 rdf:type schema:CreativeWork
337 https://doi.org/10.2337/diacare.26.11.3093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006292806
338 rdf:type schema:CreativeWork
339 https://doi.org/10.2337/diacare.26.11.3102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026282993
340 rdf:type schema:CreativeWork
341 https://doi.org/10.2337/diacare.28.2.500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052772978
342 rdf:type schema:CreativeWork
343 https://doi.org/10.7326/0003-4819-137-1-200207020-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073705509
344 rdf:type schema:CreativeWork
345 https://www.grid.ac/institutes/grid.10025.36 schema:alternateName University of Liverpool
346 schema:name University of Liverpool Management School, Chatham Street, L69 7ZH, Liverpool, UK
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
349 schema:name Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Newcastle, UK
350 rdf:type schema:Organization
351 https://www.grid.ac/institutes/grid.241103.5 schema:alternateName University Hospital of Wales
352 schema:name Department of Medicine, University Hospital of Wales, Cardiff, UK
353 rdf:type schema:Organization
354 https://www.grid.ac/institutes/grid.418019.5 schema:alternateName GlaxoSmithKline (United States)
355 schema:name GlaxoSmithKline Research and Development, Philadelphia, PA, USA
356 rdf:type schema:Organization
357 https://www.grid.ac/institutes/grid.418236.a schema:alternateName GlaxoSmithKline (United Kingdom)
358 schema:name GlaxoSmithKline Research and Development, Harlow, UK
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.5685.e schema:alternateName University of York
361 schema:name York Health Economics Consortium, University of York, York, UK
362 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...