Some Aspects of the Pharmacology of β-Adrenoreceptor Blockers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1976-06

AUTHORS

B. Åblad, E. Carlsson, C. Dahlöf, L. Ek

ABSTRACT

The pharmacodynamic properties of a β-blocker are mainly determined by its affinity to β1 andβ2-receptors respectively and by its intrinsic activity. It is suggested that there is no absolute organ separation of the two receptor sub-types. Instead bothβ1 andβ2 -receptors are involved in the mediation of the same effect. The frequency distribution ratio of β1/β2-receptors varies markedly among various effector responses.A non-selective and aβ1-selective blocker may have different haemodynamic effects when the levels of circulating adrenaline are high, because of their markedly different potency in inhibiting theβ2-mediated vasodilator effect of adrenaline. Data are presented which suggest the existence of a presynapticβ1 -receptor mediating a positive feedback mechanism on neuronal release of noradrenaline. More... »

PAGES

100-111

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00003495-197600111-00025

DOI

http://dx.doi.org/10.2165/00003495-197600111-00025

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045796379

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6242


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