Disposition of Liposomal Daunorubicin During Cotreatment with Cytarabine in Patients with Leukaemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-08

AUTHORS

Federico Pea, Domenico Russo, Mariagrazia Michieli, Daniela Damiani, Renato Fanin, Angela Michelutti, Teresa Michelutti, Stefano Piccolrovazzi, Michele Baccarani, Mario Furlanut

ABSTRACT

OBJECTIVE: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunorubicin (DaunoXome) 80 or 100 mg/m(2) on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia. DESIGN: Unblinded pharmacokinetic-pharmacodynamic study. PARTICIPANTS: Twenty-three adult patients with acute leukaemia. METHODS: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunorubicin and daunorubicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography. RESULTS: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunorubicin than for free daunorubicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunorubicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m(2), total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol. CONCLUSIONS: Liposomal daunorubicin at both 80 and 100 mg/m(2) in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite. More... »

PAGES

851-862

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00003088-200342090-00004

DOI

http://dx.doi.org/10.2165/00003088-200342090-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049102369

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12882589


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytarabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Daunorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liposomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Precursor Cell Lymphoblastic Leukemia-Lymphoma", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Udine", 
          "id": "https://www.grid.ac/institutes/grid.5390.f", 
          "name": [
            "Department of Experimental and Clinical Pathology and Medicine, Institute of Clinical Pharmacology and Toxicology, University of Udine, P. le S.M. Misericordia 3, 33100, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pea", 
        "givenName": "Federico", 
        "id": "sg:person.0725711337.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725711337.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Russo", 
        "givenName": "Domenico", 
        "id": "sg:person.01033477037.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033477037.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Division of Medical Oncology, Istituto Nazionale Tumori, Aviano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michieli", 
        "givenName": "Mariagrazia", 
        "id": "sg:person.0633657425.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633657425.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Damiani", 
        "givenName": "Daniela", 
        "id": "sg:person.01104271471.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104271471.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fanin", 
        "givenName": "Renato", 
        "id": "sg:person.01364770162.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364770162.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michelutti", 
        "givenName": "Angela", 
        "id": "sg:person.0754701275.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754701275.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Santa Maria della Misericordia di Udine", 
          "id": "https://www.grid.ac/institutes/grid.411492.b", 
          "name": [
            "Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michelutti", 
        "givenName": "Teresa", 
        "id": "sg:person.0611314316.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611314316.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gilead Sciences (Italy)", 
          "id": "https://www.grid.ac/institutes/grid.488276.7", 
          "name": [
            "Gilead Sciences, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piccolrovazzi", 
        "givenName": "Stefano", 
        "id": "sg:person.01326673222.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326673222.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bologna", 
          "id": "https://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "Institute of Hematology and Medical Oncology \u2018L. and A. Seragnoli\u2019, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baccarani", 
        "givenName": "Michele", 
        "id": "sg:person.01016466503.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016466503.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Udine", 
          "id": "https://www.grid.ac/institutes/grid.5390.f", 
          "name": [
            "Department of Experimental and Clinical Pathology and Medicine, Institute of Clinical Pharmacology and Toxicology, University of Udine, P. le S.M. Misericordia 3, 33100, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furlanut", 
        "givenName": "Mario", 
        "id": "sg:person.01156366337.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156366337.91"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0002-9343(77)90315-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001448669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007691-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001610512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00007691-198903000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001610512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hon.2900100207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001632144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002029939", 
          "https://doi.org/10.1007/bf00686300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00686300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002029939", 
          "https://doi.org/10.1007/bf00686300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(85)90017-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002091224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800000206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002364683", 
          "https://doi.org/10.1007/s002800000206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1999.01505.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004872332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19900901)66:5<868::aid-cncr2820660510>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007644977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00874439", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009508411", 
          "https://doi.org/10.1007/bf00874439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800050956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009817975", 
          "https://doi.org/10.1007/s002800050956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.pa.36.040196.001113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010847748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00257291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013594004", 
          "https://doi.org/10.1007/bf00257291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00257291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013594004", 
          "https://doi.org/10.1007/bf00257291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.2950240604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014824260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1999.01172.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015929310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1476-5381.1971.tb07219.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019482833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt1972136895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019742254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800000163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022931706", 
          "https://doi.org/10.1007/s002800000163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cpt197112196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023177082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025201424", 
          "https://doi.org/10.1038/bjc.1994.57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025201424", 
          "https://doi.org/10.1038/bjc.1994.57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027271208", 
          "https://doi.org/10.1038/bjc.1994.301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1994.301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027271208", 
          "https://doi.org/10.1038/bjc.1994.301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010701)92:1<7::aid-cncr1285>3.0.co;2-d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029214442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)79797-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029875592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/08982109409037058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032023545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/taap.1993.1023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033466416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2141.1997.d01-2020.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033603359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003495-199700544-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034477119", 
          "https://doi.org/10.2165/00003495-199700544-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(96)00453-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039223726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042060116", 
          "https://doi.org/10.1007/bf00262582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00262582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042060116", 
          "https://doi.org/10.1007/bf00262582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9343(78)90802-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044949685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(96)00003-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045144856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0169-409x(95)00029-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046272718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/10428199309147379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050842340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/84.10.804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059817197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077068991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.7.1199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077290737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077670169", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079167192", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1989.7.9.1260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079333928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1988.6.5.802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079588514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080321760", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080398156", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081176382", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081783469", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1995.13.4.996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082473771"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.7.6.8097173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082649828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082778622", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083215843", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083263791", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-08", 
    "datePublishedReg": "2003-08-01", 
    "description": "OBJECTIVE: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunorubicin (DaunoXome) 80 or 100 mg/m(2) on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia.\nDESIGN: Unblinded pharmacokinetic-pharmacodynamic study.\nPARTICIPANTS: Twenty-three adult patients with acute leukaemia.\nMETHODS: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunorubicin and daunorubicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography.\nRESULTS: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunorubicin than for free daunorubicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunorubicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m(2), total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol.\nCONCLUSIONS: Liposomal daunorubicin at both 80 and 100 mg/m(2) in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2165/00003088-200342090-00004", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1085321", 
        "issn": [
          "0312-5963", 
          "1179-1926"
        ], 
        "name": "Clinical Pharmacokinetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Disposition of Liposomal Daunorubicin During Cotreatment with Cytarabine in Patients with Leukaemia", 
    "pagination": "851-862", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e9eac5a0ccff1deb87f0b053d7f7e37c9ecf739f9335eb66f577943ce9a54130"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12882589"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7606849"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2165/00003088-200342090-00004"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049102369"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2165/00003088-200342090-00004", 
      "https://app.dimensions.ai/details/publication/pub.1049102369"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70049_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.2165/00003088-200342090-00004"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/00003088-200342090-00004'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/00003088-200342090-00004'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/00003088-200342090-00004'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/00003088-200342090-00004'


 

This table displays all metadata directly associated to this object as RDF triples.

336 TRIPLES      21 PREDICATES      89 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2165/00003088-200342090-00004 schema:about N0032bb3f72f1455f8d5e50be35fad8f4
2 N14dda66b362f4af985d939518f1a8951
3 N1a508e35933c4680a9e40b42d099a86c
4 N1a9229f471e34536b5a37a32da8c971e
5 N25c8d7fb774a4b2da6824b944fc729ba
6 N35a17d62625b4f8c94e9fcad89f84ccc
7 N3711b2a6ac914c6a9dd73cc9002a8cd8
8 N811ad784f50a4baba60d9dbd953a841f
9 N94ac6a04b2a94a1cb1487ff1ef56957e
10 N98ffca2d716b43cead6e75e9ef5027d1
11 Nade9a27ec1f842eca0990e89f97a8e63
12 Nff857aa80ae545238e5f2876462c43f7
13 anzsrc-for:11
14 anzsrc-for:1102
15 schema:author N18c4d284aa02449ab8b2c5f16dd41d9f
16 schema:citation sg:pub.10.1007/bf00257291
17 sg:pub.10.1007/bf00262582
18 sg:pub.10.1007/bf00686300
19 sg:pub.10.1007/bf00874439
20 sg:pub.10.1007/s002800000163
21 sg:pub.10.1007/s002800000206
22 sg:pub.10.1007/s002800050956
23 sg:pub.10.1038/bjc.1994.301
24 sg:pub.10.1038/bjc.1994.57
25 sg:pub.10.2165/00003495-199700544-00004
26 https://app.dimensions.ai/details/publication/pub.1077068991
27 https://app.dimensions.ai/details/publication/pub.1077670169
28 https://app.dimensions.ai/details/publication/pub.1079167192
29 https://app.dimensions.ai/details/publication/pub.1080321760
30 https://app.dimensions.ai/details/publication/pub.1080398156
31 https://app.dimensions.ai/details/publication/pub.1081176382
32 https://app.dimensions.ai/details/publication/pub.1081783469
33 https://app.dimensions.ai/details/publication/pub.1082778622
34 https://app.dimensions.ai/details/publication/pub.1083215843
35 https://app.dimensions.ai/details/publication/pub.1083263791
36 https://doi.org/10.1002/1097-0142(19900901)66:5<868::aid-cncr2820660510>3.0.co;2-z
37 https://doi.org/10.1002/1097-0142(20010701)92:1<7::aid-cncr1285>3.0.co;2-d
38 https://doi.org/10.1002/cpt197112196
39 https://doi.org/10.1002/cpt1972136895
40 https://doi.org/10.1002/hon.2900100207
41 https://doi.org/10.1002/mpo.2950240604
42 https://doi.org/10.1006/taap.1993.1023
43 https://doi.org/10.1016/0002-9343(77)90315-1
44 https://doi.org/10.1016/0002-9343(78)90802-1
45 https://doi.org/10.1016/0005-2736(96)00003-x
46 https://doi.org/10.1016/0169-409x(95)00029-7
47 https://doi.org/10.1016/0277-5379(85)90017-3
48 https://doi.org/10.1016/s0140-6736(05)79797-x
49 https://doi.org/10.1016/s0169-409x(96)00453-x
50 https://doi.org/10.1046/j.1365-2141.1997.d01-2020.x
51 https://doi.org/10.1046/j.1365-2141.1999.01172.x
52 https://doi.org/10.1046/j.1365-2141.1999.01505.x
53 https://doi.org/10.1093/jnci/84.10.804
54 https://doi.org/10.1096/fasebj.7.6.8097173
55 https://doi.org/10.1097/00007691-198903000-00004
56 https://doi.org/10.1111/j.1476-5381.1971.tb07219.x
57 https://doi.org/10.1146/annurev.pa.36.040196.001113
58 https://doi.org/10.1200/jco.1988.6.5.802
59 https://doi.org/10.1200/jco.1989.7.9.1260
60 https://doi.org/10.1200/jco.1990.8.7.1199
61 https://doi.org/10.1200/jco.1995.13.4.996
62 https://doi.org/10.3109/08982109409037058
63 https://doi.org/10.3109/10428199309147379
64 schema:datePublished 2003-08
65 schema:datePublishedReg 2003-08-01
66 schema:description OBJECTIVE: To investigate the pharmacokinetics and pharmacodynamics of liposomal daunorubicin (DaunoXome) 80 or 100 mg/m(2) on days 1, 2 and 3 coadministered with standard or high-dose cytarabine to patients with poor-risk acute leukaemia. DESIGN: Unblinded pharmacokinetic-pharmacodynamic study. PARTICIPANTS: Twenty-three adult patients with acute leukaemia. METHODS: Blood, bone marrow and urine samples were collected at appropriate intervals on days 1-6. Total daunorubicin and daunorubicinol concentrations in plasma, bone marrow, peripheral blood cells and urine were measured by high performance liquid chromatography. RESULTS: Liposomal daunorubicin exhibited a markedly different pharmacokinetic behaviour from the free drug due to a slow distribution of the liposomal moiety into the body. The ratio of area under the concentration-time curve (AUC) for metabolite to parent drug was lower for liposomal daunorubicin than for free daunorubicin, mainly due to higher concentrations of the parent drug in plasma, whereas daunorubicinol exposure was more or less comparable, if not higher. After liposomal daunorubicin at both 80 and 100 mg/m(2), total daunorubicin concentrations in leukaemic cells were at least similar to those observed for free daunorubicin, and significant accumulation was also observed in bone marrow blast cells. Nineteen of 23 patients obtained a complete remission, although 13 had P-glycoprotein-overexpressing blast cells. Grade 3-4 mucositis was found only in three patients with very high AUCs for total daunorubicin and daunorubicinol. CONCLUSIONS: Liposomal daunorubicin at both 80 and 100 mg/m(2) in combination with cytarabine may represent a valid treatment for high-risk acute leukaemia. Liposomal daunorubicin may be helpful in overcoming multidrug resistance, since it shows significant accumulation into tumour target cells, irrespective of P-glycoprotein expression. The tolerability profile suggests that toxicity may be related to exposure to both the parent drug and the metabolite.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N2ec770bec7334b91b557815d22f4e9ee
71 Ne520fc37a4a44083828220c47679a76d
72 sg:journal.1085321
73 schema:name Disposition of Liposomal Daunorubicin During Cotreatment with Cytarabine in Patients with Leukaemia
74 schema:pagination 851-862
75 schema:productId N15ec235112e8472f8211434ccd24e661
76 N226f08e394064c679429b212b0ff9adf
77 N31dc64852d3d4eb3b6fd233a129c6962
78 N390978a4d670407094c8260efbbde855
79 N5dba9b13363041c2a6e71dff19394923
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049102369
81 https://doi.org/10.2165/00003088-200342090-00004
82 schema:sdDatePublished 2019-04-11T12:40
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nf13dc7982d9d4bc2bd24dc99de7f9270
85 schema:url http://link.springer.com/10.2165/00003088-200342090-00004
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0032bb3f72f1455f8d5e50be35fad8f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Liposomes
91 rdf:type schema:DefinedTerm
92 N096db717606041ab864d6f94344707d0 rdf:first sg:person.01364770162.44
93 rdf:rest N58c31f6a96a346fc9b2f1b7995be7884
94 N14dda66b362f4af985d939518f1a8951 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Adult
96 rdf:type schema:DefinedTerm
97 N15ec235112e8472f8211434ccd24e661 schema:name doi
98 schema:value 10.2165/00003088-200342090-00004
99 rdf:type schema:PropertyValue
100 N179e4141f0fd43ceb4d8fdc84ab384b0 rdf:first sg:person.01104271471.84
101 rdf:rest N096db717606041ab864d6f94344707d0
102 N18c4d284aa02449ab8b2c5f16dd41d9f rdf:first sg:person.0725711337.51
103 rdf:rest Nf1af01dfad584586aad1c982804d0eda
104 N1a0c529c7f2340d88b962f93df08d09d rdf:first sg:person.01016466503.33
105 rdf:rest N4f4314f9b8b54e408dc64bc98b4cd4ff
106 N1a508e35933c4680a9e40b42d099a86c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Humans
108 rdf:type schema:DefinedTerm
109 N1a9229f471e34536b5a37a32da8c971e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Daunorubicin
111 rdf:type schema:DefinedTerm
112 N1b76f0a85b2048879168047c787677c2 rdf:first sg:person.0633657425.75
113 rdf:rest N179e4141f0fd43ceb4d8fdc84ab384b0
114 N226f08e394064c679429b212b0ff9adf schema:name readcube_id
115 schema:value e9eac5a0ccff1deb87f0b053d7f7e37c9ecf739f9335eb66f577943ce9a54130
116 rdf:type schema:PropertyValue
117 N25c8d7fb774a4b2da6824b944fc729ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Antineoplastic Combined Chemotherapy Protocols
119 rdf:type schema:DefinedTerm
120 N2ec770bec7334b91b557815d22f4e9ee schema:issueNumber 9
121 rdf:type schema:PublicationIssue
122 N31dc64852d3d4eb3b6fd233a129c6962 schema:name dimensions_id
123 schema:value pub.1049102369
124 rdf:type schema:PropertyValue
125 N35a17d62625b4f8c94e9fcad89f84ccc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cytarabine
127 rdf:type schema:DefinedTerm
128 N3711b2a6ac914c6a9dd73cc9002a8cd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Male
130 rdf:type schema:DefinedTerm
131 N390978a4d670407094c8260efbbde855 schema:name nlm_unique_id
132 schema:value 7606849
133 rdf:type schema:PropertyValue
134 N3b199a8ed474467992080faeb13a6425 rdf:first sg:person.01326673222.13
135 rdf:rest N1a0c529c7f2340d88b962f93df08d09d
136 N4f4314f9b8b54e408dc64bc98b4cd4ff rdf:first sg:person.01156366337.91
137 rdf:rest rdf:nil
138 N58c31f6a96a346fc9b2f1b7995be7884 rdf:first sg:person.0754701275.22
139 rdf:rest N846dc48d7ccc4a63994496d017ed6858
140 N5dba9b13363041c2a6e71dff19394923 schema:name pubmed_id
141 schema:value 12882589
142 rdf:type schema:PropertyValue
143 N811ad784f50a4baba60d9dbd953a841f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Precursor Cell Lymphoblastic Leukemia-Lymphoma
145 rdf:type schema:DefinedTerm
146 N846dc48d7ccc4a63994496d017ed6858 rdf:first sg:person.0611314316.45
147 rdf:rest N3b199a8ed474467992080faeb13a6425
148 N94ac6a04b2a94a1cb1487ff1ef56957e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Middle Aged
150 rdf:type schema:DefinedTerm
151 N98ffca2d716b43cead6e75e9ef5027d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged
153 rdf:type schema:DefinedTerm
154 Nade9a27ec1f842eca0990e89f97a8e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 Ne520fc37a4a44083828220c47679a76d schema:volumeNumber 42
158 rdf:type schema:PublicationVolume
159 Nf13dc7982d9d4bc2bd24dc99de7f9270 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Nf1af01dfad584586aad1c982804d0eda rdf:first sg:person.01033477037.24
162 rdf:rest N1b76f0a85b2048879168047c787677c2
163 Nff857aa80ae545238e5f2876462c43f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Adolescent
165 rdf:type schema:DefinedTerm
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
170 schema:name Cardiorespiratory Medicine and Haematology
171 rdf:type schema:DefinedTerm
172 sg:journal.1085321 schema:issn 0312-5963
173 1179-1926
174 schema:name Clinical Pharmacokinetics
175 rdf:type schema:Periodical
176 sg:person.01016466503.33 schema:affiliation https://www.grid.ac/institutes/grid.6292.f
177 schema:familyName Baccarani
178 schema:givenName Michele
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016466503.33
180 rdf:type schema:Person
181 sg:person.01033477037.24 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
182 schema:familyName Russo
183 schema:givenName Domenico
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033477037.24
185 rdf:type schema:Person
186 sg:person.01104271471.84 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
187 schema:familyName Damiani
188 schema:givenName Daniela
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104271471.84
190 rdf:type schema:Person
191 sg:person.01156366337.91 schema:affiliation https://www.grid.ac/institutes/grid.5390.f
192 schema:familyName Furlanut
193 schema:givenName Mario
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156366337.91
195 rdf:type schema:Person
196 sg:person.01326673222.13 schema:affiliation https://www.grid.ac/institutes/grid.488276.7
197 schema:familyName Piccolrovazzi
198 schema:givenName Stefano
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326673222.13
200 rdf:type schema:Person
201 sg:person.01364770162.44 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
202 schema:familyName Fanin
203 schema:givenName Renato
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364770162.44
205 rdf:type schema:Person
206 sg:person.0611314316.45 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
207 schema:familyName Michelutti
208 schema:givenName Teresa
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611314316.45
210 rdf:type schema:Person
211 sg:person.0633657425.75 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
212 schema:familyName Michieli
213 schema:givenName Mariagrazia
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633657425.75
215 rdf:type schema:Person
216 sg:person.0725711337.51 schema:affiliation https://www.grid.ac/institutes/grid.5390.f
217 schema:familyName Pea
218 schema:givenName Federico
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725711337.51
220 rdf:type schema:Person
221 sg:person.0754701275.22 schema:affiliation https://www.grid.ac/institutes/grid.411492.b
222 schema:familyName Michelutti
223 schema:givenName Angela
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754701275.22
225 rdf:type schema:Person
226 sg:pub.10.1007/bf00257291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013594004
227 https://doi.org/10.1007/bf00257291
228 rdf:type schema:CreativeWork
229 sg:pub.10.1007/bf00262582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042060116
230 https://doi.org/10.1007/bf00262582
231 rdf:type schema:CreativeWork
232 sg:pub.10.1007/bf00686300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002029939
233 https://doi.org/10.1007/bf00686300
234 rdf:type schema:CreativeWork
235 sg:pub.10.1007/bf00874439 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009508411
236 https://doi.org/10.1007/bf00874439
237 rdf:type schema:CreativeWork
238 sg:pub.10.1007/s002800000163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022931706
239 https://doi.org/10.1007/s002800000163
240 rdf:type schema:CreativeWork
241 sg:pub.10.1007/s002800000206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002364683
242 https://doi.org/10.1007/s002800000206
243 rdf:type schema:CreativeWork
244 sg:pub.10.1007/s002800050956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009817975
245 https://doi.org/10.1007/s002800050956
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/bjc.1994.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027271208
248 https://doi.org/10.1038/bjc.1994.301
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/bjc.1994.57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025201424
251 https://doi.org/10.1038/bjc.1994.57
252 rdf:type schema:CreativeWork
253 sg:pub.10.2165/00003495-199700544-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034477119
254 https://doi.org/10.2165/00003495-199700544-00004
255 rdf:type schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1077068991 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1077670169 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1079167192 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1080321760 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1080398156 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1081176382 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1081783469 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1082778622 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083215843 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1083263791 schema:CreativeWork
266 https://doi.org/10.1002/1097-0142(19900901)66:5<868::aid-cncr2820660510>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1007644977
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/1097-0142(20010701)92:1<7::aid-cncr1285>3.0.co;2-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1029214442
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/cpt197112196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023177082
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/cpt1972136895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019742254
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/hon.2900100207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001632144
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/mpo.2950240604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014824260
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1006/taap.1993.1023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033466416
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/0002-9343(77)90315-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001448669
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/0002-9343(78)90802-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044949685
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/0005-2736(96)00003-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045144856
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/0169-409x(95)00029-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046272718
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/0277-5379(85)90017-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002091224
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/s0140-6736(05)79797-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029875592
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/s0169-409x(96)00453-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039223726
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1046/j.1365-2141.1997.d01-2020.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033603359
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1046/j.1365-2141.1999.01172.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015929310
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1046/j.1365-2141.1999.01505.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004872332
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/jnci/84.10.804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059817197
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1096/fasebj.7.6.8097173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082649828
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1097/00007691-198903000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001610512
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1476-5381.1971.tb07219.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019482833
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1146/annurev.pa.36.040196.001113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010847748
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1200/jco.1988.6.5.802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079588514
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1200/jco.1989.7.9.1260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079333928
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1200/jco.1990.8.7.1199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077290737
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1200/jco.1995.13.4.996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082473771
317 rdf:type schema:CreativeWork
318 https://doi.org/10.3109/08982109409037058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032023545
319 rdf:type schema:CreativeWork
320 https://doi.org/10.3109/10428199309147379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050842340
321 rdf:type schema:CreativeWork
322 https://www.grid.ac/institutes/grid.411492.b schema:alternateName Ospedale Santa Maria della Misericordia di Udine
323 schema:name Department of Medical and Morphologic Research, and Division of Hematology, Chair of Hematology, Udine University Hospital, Udine, Italy
324 rdf:type schema:Organization
325 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
326 schema:name Division of Medical Oncology, Istituto Nazionale Tumori, Aviano, Italy
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.488276.7 schema:alternateName Gilead Sciences (Italy)
329 schema:name Gilead Sciences, Milano, Italy
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.5390.f schema:alternateName University of Udine
332 schema:name Department of Experimental and Clinical Pathology and Medicine, Institute of Clinical Pharmacology and Toxicology, University of Udine, P. le S.M. Misericordia 3, 33100, Udine, Italy
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.6292.f schema:alternateName University of Bologna
335 schema:name Institute of Hematology and Medical Oncology ‘L. and A. Seragnoli’, University of Bologna, Bologna, Italy
336 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...