Atrial Natriuretic Peptide View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-01

AUTHORS

Adriaan C. I. T. L. Tan, Frans G. M. Russel, Theo Thien, Theo J. Benraad

ABSTRACT

The atrial natriuretic peptide (ANP) is part of a new family of cardiac hormones regulating water and salt homeostasis. Besides acting as a blood pressure-lowering agent, it also exerts potent natriuretic and diuretic effects. ANP can be considered an endogenous antagonist of the renin-angiotensin-aldosterone system and the antidiuretic hormone. One of the roles of ANP is to protect the body against fluid overload: it decreases intravascular fluid volume, which in turn diminishes cardiac secretion of ANP. The pharmacokinetic parameters of ANP reported in the literature vary widely. In general, ANP rapidly disappears from plasma with a high total body clearance. This is in agreement with the short-lived effects of the hormone. The actions of ANP have led to efforts to use this peptide hormone in the treatment of various cardiovascular dis-orders such as hypertension and congestive heart failure. Intravenous ANP administration indeed resulted in beneficial effects in these disorders. However, the peptide nature of ANP and its rapid elimination from the circulation limit its suitability as a drug. More promising is the development of long-acting ANP analogues and inhibitors of ANP degradation. Proper understanding of ANP pharmacokinetics is essential for the clinical use of these pharmacological agents. More... »

PAGES

28-45

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00003088-199324010-00003

DOI

http://dx.doi.org/10.2165/00003088-199324010-00003

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016172365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8448971


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