Pharmacokinetic Analysis of Azelaic Acid Disodium Salt View Full Text


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Article Info

DATE

1991-05

AUTHORS

Alessandro Bertuzzi, Alberto Gandolfi, Serenella Salinari, Geltrude Mingrone, Emma Arcieri-Mastromattei, Enrico Finotti, Aldo V. Greco

ABSTRACT

Azelaic acid was the first dicarboxylic acid proposed as an alternative energy substrate in total parenteral nutrition. In this study, the pharmacokinetics of azelaic acid were investigated in 12 healthy volunteers, 7 receiving a constant infusion (10g over 90 min) and 5 a bolus dose (1g). The 24h urinary excretion and plasma concentration in blood samples taken at regular intervals were assayed by gas-liquid chromatography. Experimental data were analysed by a 2-compartment nonlinear model that describes both tubular secretion and cellular uptake in Michaelis-Menten terms. A high value of urinary excretion (mean 76.9% of infused dose) and a mean clearance of 8.42 L/h were found, suggesting the presence of tubular secretion. Estimating the population mean of the pharmacokinetic model parameters gave a maximal cellular uptake of 0.657 g/h. The model predicts that 90% of the maximal uptake should be reached in the plateau phase of a constant infusion of 2.2 g/h. The presence of extensive and rapid losses through urinary excretion, and the low estimated value of the maximal cellular uptake, indicate that azelaic acid is not suitable as an energy substrate for total parenteral nutrition. More... »

PAGES

411-419

References to SciGraph publications

  • 1989-07. Population Pharmacokinetic Analysis of Bisoprolol in CLINICAL PHARMACOKINETICS
  • 1977-10. Estimation of population characteristics of pharmacokinetic parameters from routine clinical data in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • 1984-03. Secretion and contraluminal uptake of dicarboxylic acids in the proximal convolution of rat kidney in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1987-01. Contraluminal para-aminohippurate (PAH) transport in the proximal tubule of the rat kidney in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • 1989-01. Saturable Pharmacokinetics in the Renal Excretion of Drugs in CLINICAL PHARMACOKINETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2165/00003088-199120050-00005

    DOI

    http://dx.doi.org/10.2165/00003088-199120050-00005

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024633464

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1908756


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