Physiological Changes Due to Age View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

James F. Morris

ABSTRACT

The pulmonary system is modified in various ways over time and it is particularly vulnerable to environmental insults. Of particular interest are the implications of aging for therapy of respiratory illnesses. The changes in pulmonary structure and function due simply to aging, and changes due to diseases, should be distinguished from each other.The great reserve function of the lung permits reasonable physical capacity in healthy individuals despite aging changes. In principle, loss of function equivalent to more than one lung is necessary to impair aerobic capacity at any age.Elderly people are subject to the same respiratory diseases as younger adults but may manifest them differently. They may present in atypical ways such as in bacterial pneumonia, tuberculosis, and asthma, all modified by anatomical alterations or deterioration of immunological defence mechanisms.Accumulation of toxic substances over time such as cigarette smoke or environmental pollutants may give rise to chronic bronchitis, emphysema, bronchogenic carcinoma and interstitial lung disease.Changes in the number or function of airway receptors modulate responses to bronchodilator drugs. Chronic inflammation of the bronchial wall has blurred the distinction between traditional asthma and chronic bronchitis and emphysema, and similar drug therapy can be useful for all.Adverse reactions to respiratory drugs such as theophylline, oral corticosteroids, and isoniazid increase with age. As more data accumulate, drug therapy of respiratory diseases in older patients will become more effective and safer. More... »

PAGES

207-220

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.2165/00002512-199404030-00004

DOI

http://dx.doi.org/10.2165/00002512-199404030-00004

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016511455

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8199395


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Physiological Phenomena", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Respiratory Tract Diseases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Veterans Administration Medical Centre, Portland, Oregon, USA", 
          "id": "http://www.grid.ac/institutes/grid.418356.d", 
          "name": [
            "Veterans Administration Medical Centre, Portland, Oregon, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morris", 
        "givenName": "James F.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.2165/00003495-199244030-00011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050901260", 
          "https://doi.org/10.2165/00003495-199244030-00011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-199101040-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018761703", 
          "https://doi.org/10.2165/00002512-199101040-00006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-199303010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043099861", 
          "https://doi.org/10.2165/00002512-199303010-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/267856a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042523748", 
          "https://doi.org/10.1038/267856a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4757-2093-8_28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016588727", 
          "https://doi.org/10.1007/978-1-4757-2093-8_28"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-03", 
    "datePublishedReg": "1994-03-01", 
    "description": "The pulmonary system is modified in various ways over time and it is particularly vulnerable to environmental insults. Of particular interest are the implications of aging for therapy of respiratory illnesses. The changes in pulmonary structure and function due simply to aging, and changes due to diseases, should be distinguished from each other.The great reserve function of the lung permits reasonable physical capacity in healthy individuals despite aging changes. In principle, loss of function equivalent to more than one lung is necessary to impair aerobic capacity at any age.Elderly people are subject to the same respiratory diseases as younger adults but may manifest them differently. They may present in atypical ways such as in bacterial pneumonia, tuberculosis, and asthma, all modified by anatomical alterations or deterioration of immunological defence mechanisms.Accumulation of toxic substances over time such as cigarette smoke or environmental pollutants may give rise to chronic bronchitis, emphysema, bronchogenic carcinoma and interstitial lung disease.Changes in the number or function of airway receptors modulate responses to bronchodilator drugs. Chronic inflammation of the bronchial wall has blurred the distinction between traditional asthma and chronic bronchitis and emphysema, and similar drug therapy can be useful for all.Adverse reactions to respiratory drugs such as theophylline, oral corticosteroids, and isoniazid increase with age. As more data accumulate, drug therapy of respiratory diseases in older patients will become more effective and safer.", 
    "genre": "article", 
    "id": "sg:pub.10.2165/00002512-199404030-00004", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1100990", 
        "issn": [
          "1170-229X", 
          "1179-1969"
        ], 
        "name": "Drugs & Aging", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "keywords": [
      "chronic bronchitis", 
      "drug therapy", 
      "respiratory disease", 
      "similar drug therapy", 
      "interstitial lung disease", 
      "immunological defense mechanisms", 
      "oral corticosteroids", 
      "airway receptors", 
      "older patients", 
      "bacterial pneumonia", 
      "bronchogenic carcinoma", 
      "respiratory illness", 
      "chronic inflammation", 
      "lung disease", 
      "adverse reactions", 
      "respiratory drugs", 
      "bronchial wall", 
      "pulmonary system", 
      "cigarette smoke", 
      "healthy individuals", 
      "loss of function", 
      "pulmonary structure", 
      "aerobic capacity", 
      "reserve function", 
      "disease", 
      "physical capacity", 
      "therapy", 
      "young adults", 
      "elderly people", 
      "anatomical alterations", 
      "asthma", 
      "bronchitis", 
      "emphysema", 
      "lung", 
      "environmental insults", 
      "age", 
      "physiological changes", 
      "drugs", 
      "defense mechanisms", 
      "atypical way", 
      "corticosteroids", 
      "pneumonia", 
      "inflammation", 
      "patients", 
      "carcinoma", 
      "toxic substances", 
      "illness", 
      "tuberculosis", 
      "insult", 
      "more data", 
      "receptors", 
      "adults", 
      "environmental pollutants", 
      "changes", 
      "alterations", 
      "smoke", 
      "function", 
      "individuals", 
      "deterioration", 
      "response", 
      "substances", 
      "accumulation", 
      "time", 
      "increase", 
      "loss", 
      "particular interest", 
      "people", 
      "mechanism", 
      "capacity", 
      "data", 
      "wall", 
      "number", 
      "implications", 
      "reaction", 
      "interest", 
      "distinction", 
      "system", 
      "way", 
      "pollutants", 
      "principles", 
      "structure"
    ], 
    "name": "Physiological Changes Due to Age", 
    "pagination": "207-220", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016511455"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2165/00002512-199404030-00004"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8199395"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2165/00002512-199404030-00004", 
      "https://app.dimensions.ai/details/publication/pub.1016511455"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_231.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.2165/00002512-199404030-00004"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2165/00002512-199404030-00004'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2165/00002512-199404030-00004'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2165/00002512-199404030-00004'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2165/00002512-199404030-00004'


 

This table displays all metadata directly associated to this object as RDF triples.

185 TRIPLES      21 PREDICATES      118 URIs      104 LITERALS      12 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2165/00002512-199404030-00004 schema:about N7e91e81b804940bc97d2778d8712888e
2 N8d24eec9ba58401a9562e1d8c55f81d0
3 Nad91150aff4349f5ac3224236f704618
4 Ncfa4f0ebc940484dafd8f45266d53d27
5 Nfccaedce6ea243c5b38ea652a95b022c
6 anzsrc-for:11
7 anzsrc-for:1102
8 anzsrc-for:1115
9 schema:author N6ddaa9bf72744e148844a113dd34dbb2
10 schema:citation sg:pub.10.1007/978-1-4757-2093-8_28
11 sg:pub.10.1038/267856a0
12 sg:pub.10.2165/00002512-199101040-00006
13 sg:pub.10.2165/00002512-199303010-00004
14 sg:pub.10.2165/00003495-199244030-00011
15 schema:datePublished 1994-03
16 schema:datePublishedReg 1994-03-01
17 schema:description The pulmonary system is modified in various ways over time and it is particularly vulnerable to environmental insults. Of particular interest are the implications of aging for therapy of respiratory illnesses. The changes in pulmonary structure and function due simply to aging, and changes due to diseases, should be distinguished from each other.The great reserve function of the lung permits reasonable physical capacity in healthy individuals despite aging changes. In principle, loss of function equivalent to more than one lung is necessary to impair aerobic capacity at any age.Elderly people are subject to the same respiratory diseases as younger adults but may manifest them differently. They may present in atypical ways such as in bacterial pneumonia, tuberculosis, and asthma, all modified by anatomical alterations or deterioration of immunological defence mechanisms.Accumulation of toxic substances over time such as cigarette smoke or environmental pollutants may give rise to chronic bronchitis, emphysema, bronchogenic carcinoma and interstitial lung disease.Changes in the number or function of airway receptors modulate responses to bronchodilator drugs. Chronic inflammation of the bronchial wall has blurred the distinction between traditional asthma and chronic bronchitis and emphysema, and similar drug therapy can be useful for all.Adverse reactions to respiratory drugs such as theophylline, oral corticosteroids, and isoniazid increase with age. As more data accumulate, drug therapy of respiratory diseases in older patients will become more effective and safer.
18 schema:genre article
19 schema:isAccessibleForFree false
20 schema:isPartOf N3df9aa38612743009f6d63fbae1b6bbf
21 Nf59b68b61c2142799d0a5f276991682a
22 sg:journal.1100990
23 schema:keywords accumulation
24 adults
25 adverse reactions
26 aerobic capacity
27 age
28 airway receptors
29 alterations
30 anatomical alterations
31 asthma
32 atypical way
33 bacterial pneumonia
34 bronchial wall
35 bronchitis
36 bronchogenic carcinoma
37 capacity
38 carcinoma
39 changes
40 chronic bronchitis
41 chronic inflammation
42 cigarette smoke
43 corticosteroids
44 data
45 defense mechanisms
46 deterioration
47 disease
48 distinction
49 drug therapy
50 drugs
51 elderly people
52 emphysema
53 environmental insults
54 environmental pollutants
55 function
56 healthy individuals
57 illness
58 immunological defense mechanisms
59 implications
60 increase
61 individuals
62 inflammation
63 insult
64 interest
65 interstitial lung disease
66 loss
67 loss of function
68 lung
69 lung disease
70 mechanism
71 more data
72 number
73 older patients
74 oral corticosteroids
75 particular interest
76 patients
77 people
78 physical capacity
79 physiological changes
80 pneumonia
81 pollutants
82 principles
83 pulmonary structure
84 pulmonary system
85 reaction
86 receptors
87 reserve function
88 respiratory disease
89 respiratory drugs
90 respiratory illness
91 response
92 similar drug therapy
93 smoke
94 structure
95 substances
96 system
97 therapy
98 time
99 toxic substances
100 tuberculosis
101 wall
102 way
103 young adults
104 schema:name Physiological Changes Due to Age
105 schema:pagination 207-220
106 schema:productId N81e02f9d06fb4103a0c3dc272159ff36
107 N8b29266b39c54cb5bd6e7d6667f6d3a3
108 Nb44e95cd98eb4e83a73a53c243115dcd
109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016511455
110 https://doi.org/10.2165/00002512-199404030-00004
111 schema:sdDatePublished 2022-10-01T06:28
112 schema:sdLicense https://scigraph.springernature.com/explorer/license/
113 schema:sdPublisher N7a060c50122a4fc99e6e5a6b663598f2
114 schema:url https://doi.org/10.2165/00002512-199404030-00004
115 sgo:license sg:explorer/license/
116 sgo:sdDataset articles
117 rdf:type schema:ScholarlyArticle
118 N3df9aa38612743009f6d63fbae1b6bbf schema:issueNumber 3
119 rdf:type schema:PublicationIssue
120 N5fd26d5959e140fa9cd7a3c547333291 schema:affiliation grid-institutes:grid.418356.d
121 schema:familyName Morris
122 schema:givenName James F.
123 rdf:type schema:Person
124 N6ddaa9bf72744e148844a113dd34dbb2 rdf:first N5fd26d5959e140fa9cd7a3c547333291
125 rdf:rest rdf:nil
126 N7a060c50122a4fc99e6e5a6b663598f2 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N7e91e81b804940bc97d2778d8712888e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Respiratory Physiological Phenomena
130 rdf:type schema:DefinedTerm
131 N81e02f9d06fb4103a0c3dc272159ff36 schema:name dimensions_id
132 schema:value pub.1016511455
133 rdf:type schema:PropertyValue
134 N8b29266b39c54cb5bd6e7d6667f6d3a3 schema:name pubmed_id
135 schema:value 8199395
136 rdf:type schema:PropertyValue
137 N8d24eec9ba58401a9562e1d8c55f81d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 Nad91150aff4349f5ac3224236f704618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aging
142 rdf:type schema:DefinedTerm
143 Nb44e95cd98eb4e83a73a53c243115dcd schema:name doi
144 schema:value 10.2165/00002512-199404030-00004
145 rdf:type schema:PropertyValue
146 Ncfa4f0ebc940484dafd8f45266d53d27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Respiratory Tract Diseases
148 rdf:type schema:DefinedTerm
149 Nf59b68b61c2142799d0a5f276991682a schema:volumeNumber 4
150 rdf:type schema:PublicationVolume
151 Nfccaedce6ea243c5b38ea652a95b022c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aged
153 rdf:type schema:DefinedTerm
154 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
155 schema:name Medical and Health Sciences
156 rdf:type schema:DefinedTerm
157 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
158 schema:name Cardiorespiratory Medicine and Haematology
159 rdf:type schema:DefinedTerm
160 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
161 schema:name Pharmacology and Pharmaceutical Sciences
162 rdf:type schema:DefinedTerm
163 sg:journal.1100990 schema:issn 1170-229X
164 1179-1969
165 schema:name Drugs & Aging
166 schema:publisher Springer Nature
167 rdf:type schema:Periodical
168 sg:pub.10.1007/978-1-4757-2093-8_28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016588727
169 https://doi.org/10.1007/978-1-4757-2093-8_28
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/267856a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042523748
172 https://doi.org/10.1038/267856a0
173 rdf:type schema:CreativeWork
174 sg:pub.10.2165/00002512-199101040-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018761703
175 https://doi.org/10.2165/00002512-199101040-00006
176 rdf:type schema:CreativeWork
177 sg:pub.10.2165/00002512-199303010-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043099861
178 https://doi.org/10.2165/00002512-199303010-00004
179 rdf:type schema:CreativeWork
180 sg:pub.10.2165/00003495-199244030-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050901260
181 https://doi.org/10.2165/00003495-199244030-00011
182 rdf:type schema:CreativeWork
183 grid-institutes:grid.418356.d schema:alternateName Veterans Administration Medical Centre, Portland, Oregon, USA
184 schema:name Veterans Administration Medical Centre, Portland, Oregon, USA
185 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...