Possible Interaction between Phenobarbital, Carbamazepine and Itraconazole View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-10

AUTHORS

Marcel Bonay, Annie Pierre Jonville-Bera, Patrice Diot, Etienne Lemarie, Michel Lavandier, Elisabeth Autret

ABSTRACT

We report a case of a possible interaction between itraconazole, phenobarbital and carbamazepine. The first plasma itraconazole concentration, measured when the patient had been taking phenobarbital for 2 months, was very low. The second measurement, 2 months after withdrawing phenobarbital, was higher but below the therapeutic range. However, carbamazepine, a well known enzyme inducer, had been initiated 15 days before. 20 days after carbamazepine was withdrawn, the itraconazole concentration 4 hours after administration was near the lower end of the therapeutic range. The mechanism of this possible interaction is probably the same for phenobarbital and carbamazepine, involving hepatic microsomal enzyme system induction. More... »

PAGES

309-311

References to SciGraph publications

  • 1989-03. Itraconazole in DRUGS
  • 1992-07. Systemically Administered Antifungal Agents in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2165/00002018-199309040-00008

    DOI

    http://dx.doi.org/10.2165/00002018-199309040-00008

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048694328

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8260123


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