Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

Christoph Ott, Henrik Martens, Imam Hassouna, Barbara Oliveira, Christian Erck, Maria-Patapia Zafeiriou, Ulla-Kaisa Peteri, Dörte Hesse, Simone Gerhart, Bekir Altas, Tekla Kolbow, Herbert Stadler, Hiroshi Kawabe, Wolfram-Hubertus Zimmermann, Klaus-Armin Nave, Walter Schulz-Schaeffer, Olaf Jahn, Hannelore Ehrenreich

ABSTRACT

Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in brain cells has remained difficult since previously available anti-EPOR antibodies (EPOR-AB) were unspecific. We report here a new, highly specific, polyclonal rabbit EPOR-AB directed against different epitopes in the cytoplasmic tail of human and murine EPOR and its characterization by mass spectrometric analysis of immuno-precipitated endogenous EPOR, Western blotting, immunostaining and flow cytometry. Among others, we applied genetic strategies including overexpression, Lentivirus-mediated conditional knockout of EpoR and tagged proteins, both on cultured cells and tissue sections, as well as intracortical implantation of EPOR-transduced cells to verify specificity. We show examples of EPOR expression in neurons, oligodendroglia, astrocytes and microglia. Employing this new EPOR-AB with double-labeling strategies, we demonstrate membrane expression of EPOR as well as its localization in intracellular compartments such as the Golgi apparatus. Moreover, we show injury-induced expression of EPOR. In mice, a stereotactically applied stab wound to the motor cortex leads to distinct EpoR expression by reactive GFAP-expressing cells in the lesion vicinity. In a patient suffering from epilepsy, neurons and oligodendrocytes of the hippocampus strongly express EPOR. To conclude, this new analytical tool will allow neuroscientists to pinpoint EPOR expression in cells of the nervous system and to better understand its role in healthy conditions, including brain development, as well as under pathological circumstances, such as upregulation upon distress and injury. More... »

PAGES

803-815

Identifiers

URI

http://scigraph.springernature.com/pub.10.2119/molmed.2015.00192

DOI

http://dx.doi.org/10.2119/molmed.2015.00192

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1068965790

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26349059


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ott", 
        "givenName": "Christoph", 
        "id": "sg:person.01051475160.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051475160.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Synaptic Systems GmbH, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martens", 
        "givenName": "Henrik", 
        "id": "sg:person.01123451460.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123451460.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Menoufia University", 
          "id": "https://www.grid.ac/institutes/grid.411775.1", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany", 
            "Physiology Unit, Zoology Department, Faculty of Science, Menoufia University, Menoufia, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hassouna", 
        "givenName": "Imam", 
        "id": "sg:person.0607013507.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607013507.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliveira", 
        "givenName": "Barbara", 
        "id": "sg:person.01131365322.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131365322.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Synaptic Systems GmbH, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erck", 
        "givenName": "Christian", 
        "id": "sg:person.0734062725.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734062725.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Institute of Pharmacology, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zafeiriou", 
        "givenName": "Maria-Patapia", 
        "id": "sg:person.016063232641.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016063232641.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peteri", 
        "givenName": "Ulla-Kaisa", 
        "id": "sg:person.016660613241.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016660613241.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Proteomics Group, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hesse", 
        "givenName": "D\u00f6rte", 
        "id": "sg:person.0672100152.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672100152.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gerhart", 
        "givenName": "Simone", 
        "id": "sg:person.0757717755.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757717755.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Molecular Neurobiology, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altas", 
        "givenName": "Bekir", 
        "id": "sg:person.012250453525.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012250453525.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Synaptic Systems GmbH, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kolbow", 
        "givenName": "Tekla", 
        "id": "sg:person.01053404736.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053404736.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Synaptic Systems GmbH, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stadler", 
        "givenName": "Herbert", 
        "id": "sg:person.012351724541.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351724541.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Molecular Neurobiology, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawabe", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01021033661.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021033661.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Institute of Pharmacology, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmermann", 
        "givenName": "Wolfram-Hubertus", 
        "id": "sg:person.01204207533.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204207533.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Neurogenetics, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany", 
            "DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nave", 
        "givenName": "Klaus-Armin", 
        "id": "sg:person.011232626157.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011232626157.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "Department of Neuropathology, University Medicine G\u00f6ttingen, G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schulz-Schaeffer", 
        "givenName": "Walter", 
        "id": "sg:person.01165570517.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165570517.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Proteomics Group, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany", 
            "DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jahn", 
        "givenName": "Olaf", 
        "id": "sg:person.01262700524.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262700524.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Clinical Neuroscience, Max Planck Institute of Experimental Medicine, G\u00f6ttingen, Germany", 
            "DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehrenreich", 
        "givenName": "Hannelore", 
        "id": "sg:person.01371370041.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371370041.83"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)60992-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000168792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2005-10-4066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000372953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.20839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000392167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-012-6197-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000502427", 
          "https://doi.org/10.1007/s00216-012-6197-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2013.155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002318404", 
          "https://doi.org/10.1038/pr.2013.155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002517591", 
          "https://doi.org/10.1038/nrn1687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002517591", 
          "https://doi.org/10.1038/nrn1687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn1687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002517591", 
          "https://doi.org/10.1038/nrn1687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/glia.22648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005861243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0406008102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006110275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvg.20335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006785349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2009-10-248666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007805126"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200800564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009040630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200800564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009040630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1462399408000860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014018766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2015.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015518251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2015.100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015518251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.nurt.2008.10.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015831272", 
          "https://doi.org/10.1016/j.nurt.2008.10.041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jim.2009.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017012167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.4480-05.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022440815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.051606598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022542950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1001577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023589046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.9.3717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026469395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027604077", 
          "https://doi.org/10.1038/sj.mp.4001442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.mp.4001442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027604077", 
          "https://doi.org/10.1038/sj.mp.4001442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(84)90782-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028017476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1471-4159.2007.04684.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029967237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032502527", 
          "https://doi.org/10.1038/nmeth.2767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0609.2007.00818.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033280877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bjh.13133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037180337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037983118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-011-2511-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038535602", 
          "https://doi.org/10.1007/s00213-011-2511-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.201200366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038935794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000356193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039331350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(89)90965-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041641412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2001.013277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042488963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2006-0687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045207122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.2008.07014.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047345091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpa.2010.10.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048845798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m500230-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049945817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jneumeth.2007.03.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052822728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac048455k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054996116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac048455k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054996116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1184913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1184913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062461436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004010000297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074800814", 
          "https://doi.org/10.1007/s004010000297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-24-09733.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074962531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074985970", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077236245", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078405378", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-01", 
    "datePublishedReg": "2015-01-01", 
    "description": "Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in brain cells has remained difficult since previously available anti-EPOR antibodies (EPOR-AB) were unspecific. We report here a new, highly specific, polyclonal rabbit EPOR-AB directed against different epitopes in the cytoplasmic tail of human and murine EPOR and its characterization by mass spectrometric analysis of immuno-precipitated endogenous EPOR, Western blotting, immunostaining and flow cytometry. Among others, we applied genetic strategies including overexpression, Lentivirus-mediated conditional knockout of EpoR and tagged proteins, both on cultured cells and tissue sections, as well as intracortical implantation of EPOR-transduced cells to verify specificity. We show examples of EPOR expression in neurons, oligodendroglia, astrocytes and microglia. Employing this new EPOR-AB with double-labeling strategies, we demonstrate membrane expression of EPOR as well as its localization in intracellular compartments such as the Golgi apparatus. Moreover, we show injury-induced expression of EPOR. In mice, a stereotactically applied stab wound to the motor cortex leads to distinct EpoR expression by reactive GFAP-expressing cells in the lesion vicinity. In a patient suffering from epilepsy, neurons and oligodendrocytes of the hippocampus strongly express EPOR. To conclude, this new analytical tool will allow neuroscientists to pinpoint EPOR expression in cells of the nervous system and to better understand its role in healthy conditions, including brain development, as well as under pathological circumstances, such as upregulation upon distress and injury.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2119/molmed.2015.00192", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1113628", 
        "issn": [
          "1076-1551", 
          "1528-3658"
        ], 
        "name": "Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury", 
    "pagination": "803-815", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c56848d8b4faf5501a913af8100519ebd1bd7e7c5ed56fc02b4d699b17226f65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26349059"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9501023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2119/molmed.2015.00192"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1068965790"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2119/molmed.2015.00192", 
      "https://app.dimensions.ai/details/publication/pub.1068965790"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117125_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.2119%2Fmolmed.2015.00192"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2119/molmed.2015.00192'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2119/molmed.2015.00192'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2119/molmed.2015.00192'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2119/molmed.2015.00192'


 

This table displays all metadata directly associated to this object as RDF triples.

342 TRIPLES      21 PREDICATES      72 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2119/molmed.2015.00192 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N429144ed0bd847ab98bdda9a1dfa01de
4 schema:citation sg:pub.10.1007/s00213-011-2511-1
5 sg:pub.10.1007/s00216-012-6197-y
6 sg:pub.10.1007/s004010000297
7 sg:pub.10.1016/j.nurt.2008.10.041
8 sg:pub.10.1038/nmeth.2767
9 sg:pub.10.1038/nrn1687
10 sg:pub.10.1038/pr.2013.155
11 sg:pub.10.1038/sj.mp.4001442
12 https://app.dimensions.ai/details/publication/pub.1074985970
13 https://app.dimensions.ai/details/publication/pub.1077236245
14 https://app.dimensions.ai/details/publication/pub.1078405378
15 https://doi.org/10.1002/cne.20839
16 https://doi.org/10.1002/dvg.20335
17 https://doi.org/10.1002/glia.22648
18 https://doi.org/10.1002/pmic.200800564
19 https://doi.org/10.1002/pmic.201200366
20 https://doi.org/10.1002/stem.1202
21 https://doi.org/10.1016/0003-2697(84)90782-6
22 https://doi.org/10.1016/0092-8674(89)90965-3
23 https://doi.org/10.1016/j.bpa.2010.10.005
24 https://doi.org/10.1016/j.jim.2009.10.006
25 https://doi.org/10.1016/j.jneumeth.2007.03.026
26 https://doi.org/10.1016/s0140-6736(10)60992-0
27 https://doi.org/10.1017/s1462399408000860
28 https://doi.org/10.1021/ac048455k
29 https://doi.org/10.1038/jcbfm.2015.100
30 https://doi.org/10.1073/pnas.0406008102
31 https://doi.org/10.1073/pnas.051606598
32 https://doi.org/10.1073/pnas.92.9.3717
33 https://doi.org/10.1074/mcp.m500230-mcp200
34 https://doi.org/10.1111/bjh.13133
35 https://doi.org/10.1111/j.1365-2141.2008.07014.x
36 https://doi.org/10.1111/j.1471-4159.2007.04684.x
37 https://doi.org/10.1111/j.1600-0609.2007.00818.x
38 https://doi.org/10.1113/jphysiol.2001.013277
39 https://doi.org/10.1126/science.1184913
40 https://doi.org/10.1159/000356193
41 https://doi.org/10.1182/blood-2005-10-4066
42 https://doi.org/10.1182/blood-2009-10-248666
43 https://doi.org/10.1371/journal.pbio.1001577
44 https://doi.org/10.1523/jneurosci.21-24-09733.2001
45 https://doi.org/10.1523/jneurosci.4480-05.2006
46 https://doi.org/10.1634/stemcells.2006-0687
47 schema:datePublished 2015-01
48 schema:datePublishedReg 2015-01-01
49 schema:description Erythropoietin (EPO) exerts potent neuroprotective, neuroregenerative and procognitive functions. However, unequivocal demonstration of erythropoietin receptor (EPOR) expression in brain cells has remained difficult since previously available anti-EPOR antibodies (EPOR-AB) were unspecific. We report here a new, highly specific, polyclonal rabbit EPOR-AB directed against different epitopes in the cytoplasmic tail of human and murine EPOR and its characterization by mass spectrometric analysis of immuno-precipitated endogenous EPOR, Western blotting, immunostaining and flow cytometry. Among others, we applied genetic strategies including overexpression, Lentivirus-mediated conditional knockout of <i>EpoR</i> and tagged proteins, both on cultured cells and tissue sections, as well as intracortical implantation of <i>EPOR</i>-transduced cells to verify specificity. We show examples of EPOR expression in neurons, oligodendroglia, astrocytes and microglia. Employing this new EPOR-AB with double-labeling strategies, we demonstrate membrane expression of EPOR as well as its localization in intracellular compartments such as the Golgi apparatus. Moreover, we show injury-induced expression of EPOR. In mice, a stereotactically applied stab wound to the motor cortex leads to distinct EpoR expression by reactive GFAP-expressing cells in the lesion vicinity. In a patient suffering from epilepsy, neurons and oligodendrocytes of the hippocampus strongly express EPOR. To conclude, this new analytical tool will allow neuroscientists to pinpoint EPOR expression in cells of the nervous system and to better understand its role in healthy conditions, including brain development, as well as under pathological circumstances, such as upregulation upon distress and injury.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N48ebdde0884645fe86a8cccdef68056a
54 N92519edb5e144d528dfd66432a998696
55 sg:journal.1113628
56 schema:name Widespread Expression of Erythropoietin Receptor in Brain and Its Induction by Injury
57 schema:pagination 803-815
58 schema:productId Nafc340a4661041cc81b0f87def9c6059
59 Nb2bec11f754d4b188488b0404b68b41a
60 Ne231de76df0344588e4146dc4e3ca4cd
61 Nf2a25f2574414fc7b80231e51227ea49
62 Nf533a575e9174d8dbbc356992e17351b
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965790
64 https://doi.org/10.2119/molmed.2015.00192
65 schema:sdDatePublished 2019-04-11T14:21
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N4e0f0e564e12482d8a5f5c3e6fdd6be9
68 schema:url https://link.springer.com/10.2119%2Fmolmed.2015.00192
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N15286e2592284e8f9fa61fab0c2537d7 rdf:first sg:person.01371370041.83
73 rdf:rest rdf:nil
74 N199b69f3d07d4b80b1b13c9edd97707d rdf:first sg:person.01123451460.69
75 rdf:rest Nb96a58f0e9d247f58d5699b1da589661
76 N35440be0c1a9476096e05e10fe3ccf02 rdf:first sg:person.0672100152.33
77 rdf:rest Nff6f7faab94a4a40aedfee045161acdb
78 N429144ed0bd847ab98bdda9a1dfa01de rdf:first sg:person.01051475160.99
79 rdf:rest N199b69f3d07d4b80b1b13c9edd97707d
80 N4562d27e2be04572b2e356290f6ca177 rdf:first sg:person.01131365322.46
81 rdf:rest N4b50b0e303b347968e0aefdf1b7b4bb7
82 N48ebdde0884645fe86a8cccdef68056a schema:issueNumber 1
83 rdf:type schema:PublicationIssue
84 N4b50b0e303b347968e0aefdf1b7b4bb7 rdf:first sg:person.0734062725.68
85 rdf:rest N53319d8684df4d65b70399b711e2cbb3
86 N4e0f0e564e12482d8a5f5c3e6fdd6be9 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N53319d8684df4d65b70399b711e2cbb3 rdf:first sg:person.016063232641.46
89 rdf:rest N6617d594d0e341eca2ee759e61e694b9
90 N5a25f2026f924ea8b520e823fb9e5eaf schema:name Synaptic Systems GmbH, Göttingen, Germany
91 rdf:type schema:Organization
92 N62028d8e67f348d08010a7792c9967b8 rdf:first sg:person.012250453525.49
93 rdf:rest N777726f6a7e94151b401575153538cf9
94 N6617d594d0e341eca2ee759e61e694b9 rdf:first sg:person.016660613241.43
95 rdf:rest N35440be0c1a9476096e05e10fe3ccf02
96 N72d4e55762b04394a36789fe6b5f616c schema:name Synaptic Systems GmbH, Göttingen, Germany
97 rdf:type schema:Organization
98 N777726f6a7e94151b401575153538cf9 rdf:first sg:person.01053404736.48
99 rdf:rest N838f8085e9d8490fa40a29a1d7028470
100 N7c41e3b363054554a0f8879a9c795508 rdf:first sg:person.01021033661.47
101 rdf:rest Neb3a68d4839b4d499083744c24d1608a
102 N838f8085e9d8490fa40a29a1d7028470 rdf:first sg:person.012351724541.12
103 rdf:rest N7c41e3b363054554a0f8879a9c795508
104 N891c83cb0f944e0f916814f6a2100f73 rdf:first sg:person.011232626157.03
105 rdf:rest N98be4449acb8427590a7e1b019fe6925
106 N92519edb5e144d528dfd66432a998696 schema:volumeNumber 21
107 rdf:type schema:PublicationVolume
108 N98be4449acb8427590a7e1b019fe6925 rdf:first sg:person.01165570517.26
109 rdf:rest Nf061a12fbb514853b616fc5baee267f1
110 Nafc340a4661041cc81b0f87def9c6059 schema:name nlm_unique_id
111 schema:value 9501023
112 rdf:type schema:PropertyValue
113 Nb2bec11f754d4b188488b0404b68b41a schema:name readcube_id
114 schema:value c56848d8b4faf5501a913af8100519ebd1bd7e7c5ed56fc02b4d699b17226f65
115 rdf:type schema:PropertyValue
116 Nb96a58f0e9d247f58d5699b1da589661 rdf:first sg:person.0607013507.58
117 rdf:rest N4562d27e2be04572b2e356290f6ca177
118 Nc488b2e7dbaf43f499e6ce53327fc0ed schema:name Synaptic Systems GmbH, Göttingen, Germany
119 rdf:type schema:Organization
120 Ne231de76df0344588e4146dc4e3ca4cd schema:name pubmed_id
121 schema:value 26349059
122 rdf:type schema:PropertyValue
123 Ne4653aeb597344b392cee0c6b537a1e7 schema:name Synaptic Systems GmbH, Göttingen, Germany
124 rdf:type schema:Organization
125 Neb3a68d4839b4d499083744c24d1608a rdf:first sg:person.01204207533.54
126 rdf:rest N891c83cb0f944e0f916814f6a2100f73
127 Nf061a12fbb514853b616fc5baee267f1 rdf:first sg:person.01262700524.15
128 rdf:rest N15286e2592284e8f9fa61fab0c2537d7
129 Nf2a25f2574414fc7b80231e51227ea49 schema:name doi
130 schema:value 10.2119/molmed.2015.00192
131 rdf:type schema:PropertyValue
132 Nf533a575e9174d8dbbc356992e17351b schema:name dimensions_id
133 schema:value pub.1068965790
134 rdf:type schema:PropertyValue
135 Nff6f7faab94a4a40aedfee045161acdb rdf:first sg:person.0757717755.66
136 rdf:rest N62028d8e67f348d08010a7792c9967b8
137 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
138 schema:name Medical and Health Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
141 schema:name Neurosciences
142 rdf:type schema:DefinedTerm
143 sg:journal.1113628 schema:issn 1076-1551
144 1528-3658
145 schema:name Molecular Medicine
146 rdf:type schema:Periodical
147 sg:person.01021033661.47 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
148 schema:familyName Kawabe
149 schema:givenName Hiroshi
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021033661.47
151 rdf:type schema:Person
152 sg:person.01051475160.99 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
153 schema:familyName Ott
154 schema:givenName Christoph
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051475160.99
156 rdf:type schema:Person
157 sg:person.01053404736.48 schema:affiliation N5a25f2026f924ea8b520e823fb9e5eaf
158 schema:familyName Kolbow
159 schema:givenName Tekla
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053404736.48
161 rdf:type schema:Person
162 sg:person.011232626157.03 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
163 schema:familyName Nave
164 schema:givenName Klaus-Armin
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011232626157.03
166 rdf:type schema:Person
167 sg:person.01123451460.69 schema:affiliation N72d4e55762b04394a36789fe6b5f616c
168 schema:familyName Martens
169 schema:givenName Henrik
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123451460.69
171 rdf:type schema:Person
172 sg:person.01131365322.46 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
173 schema:familyName Oliveira
174 schema:givenName Barbara
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131365322.46
176 rdf:type schema:Person
177 sg:person.01165570517.26 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
178 schema:familyName Schulz-Schaeffer
179 schema:givenName Walter
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165570517.26
181 rdf:type schema:Person
182 sg:person.01204207533.54 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
183 schema:familyName Zimmermann
184 schema:givenName Wolfram-Hubertus
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204207533.54
186 rdf:type schema:Person
187 sg:person.012250453525.49 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
188 schema:familyName Altas
189 schema:givenName Bekir
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012250453525.49
191 rdf:type schema:Person
192 sg:person.012351724541.12 schema:affiliation Nc488b2e7dbaf43f499e6ce53327fc0ed
193 schema:familyName Stadler
194 schema:givenName Herbert
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351724541.12
196 rdf:type schema:Person
197 sg:person.01262700524.15 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
198 schema:familyName Jahn
199 schema:givenName Olaf
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262700524.15
201 rdf:type schema:Person
202 sg:person.01371370041.83 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
203 schema:familyName Ehrenreich
204 schema:givenName Hannelore
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371370041.83
206 rdf:type schema:Person
207 sg:person.016063232641.46 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
208 schema:familyName Zafeiriou
209 schema:givenName Maria-Patapia
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016063232641.46
211 rdf:type schema:Person
212 sg:person.016660613241.43 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
213 schema:familyName Peteri
214 schema:givenName Ulla-Kaisa
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016660613241.43
216 rdf:type schema:Person
217 sg:person.0607013507.58 schema:affiliation https://www.grid.ac/institutes/grid.411775.1
218 schema:familyName Hassouna
219 schema:givenName Imam
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607013507.58
221 rdf:type schema:Person
222 sg:person.0672100152.33 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
223 schema:familyName Hesse
224 schema:givenName Dörte
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672100152.33
226 rdf:type schema:Person
227 sg:person.0734062725.68 schema:affiliation Ne4653aeb597344b392cee0c6b537a1e7
228 schema:familyName Erck
229 schema:givenName Christian
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734062725.68
231 rdf:type schema:Person
232 sg:person.0757717755.66 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
233 schema:familyName Gerhart
234 schema:givenName Simone
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757717755.66
236 rdf:type schema:Person
237 sg:pub.10.1007/s00213-011-2511-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038535602
238 https://doi.org/10.1007/s00213-011-2511-1
239 rdf:type schema:CreativeWork
240 sg:pub.10.1007/s00216-012-6197-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000502427
241 https://doi.org/10.1007/s00216-012-6197-y
242 rdf:type schema:CreativeWork
243 sg:pub.10.1007/s004010000297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074800814
244 https://doi.org/10.1007/s004010000297
245 rdf:type schema:CreativeWork
246 sg:pub.10.1016/j.nurt.2008.10.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015831272
247 https://doi.org/10.1016/j.nurt.2008.10.041
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nmeth.2767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032502527
250 https://doi.org/10.1038/nmeth.2767
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nrn1687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002517591
253 https://doi.org/10.1038/nrn1687
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/pr.2013.155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002318404
256 https://doi.org/10.1038/pr.2013.155
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.mp.4001442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027604077
259 https://doi.org/10.1038/sj.mp.4001442
260 rdf:type schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1074985970 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1077236245 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1078405378 schema:CreativeWork
264 https://doi.org/10.1002/cne.20839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000392167
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/dvg.20335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785349
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1002/glia.22648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005861243
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/pmic.200800564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009040630
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1002/pmic.201200366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038935794
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/stem.1202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037983118
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/0003-2697(84)90782-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028017476
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/0092-8674(89)90965-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041641412
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.bpa.2010.10.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048845798
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.jim.2009.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017012167
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.jneumeth.2007.03.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052822728
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0140-6736(10)60992-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000168792
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1017/s1462399408000860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014018766
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1021/ac048455k schema:sameAs https://app.dimensions.ai/details/publication/pub.1054996116
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1038/jcbfm.2015.100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015518251
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1073/pnas.0406008102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006110275
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.051606598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022542950
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.92.9.3717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026469395
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/mcp.m500230-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049945817
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/bjh.13133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037180337
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1365-2141.2008.07014.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047345091
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1471-4159.2007.04684.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029967237
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1600-0609.2007.00818.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033280877
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1113/jphysiol.2001.013277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042488963
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1126/science.1184913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062461436
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1159/000356193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039331350
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1182/blood-2005-10-4066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000372953
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1182/blood-2009-10-248666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007805126
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pbio.1001577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023589046
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1523/jneurosci.21-24-09733.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074962531
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1523/jneurosci.4480-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022440815
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1634/stemcells.2006-0687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045207122
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.411775.1 schema:alternateName Menoufia University
329 schema:name Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
330 Physiology Unit, Zoology Department, Faculty of Science, Menoufia University, Menoufia, Egypt
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.411984.1 schema:alternateName Universitätsmedizin Göttingen
333 schema:name Department of Neuropathology, University Medicine Göttingen, Göttingen, Germany
334 Institute of Pharmacology, University Medicine Göttingen, Göttingen, Germany
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.419522.9 schema:alternateName Max Planck Institute for Experimental Medicine
337 schema:name Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
338 DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB), Göttingen, Germany
339 Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany
340 Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany
341 Proteomics Group, Max Planck Institute of Experimental Medicine, Göttingen, Germany
342 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...