MyD88 Signaling Pathway Is Involved in Renal Fibrosis by Favoring a TH2 Immune Response and Activating Alternative M2 Macrophages View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-08

AUTHORS

Tarcio Teodoro Braga, Matheus Correa-Costa, Yuri Felipe Souza Guise, Angela Castoldi, Cassiano Donizetti de Oliveira, Meire Ioshie Hyane, Marcos Antonio Cenedeze, Simone Aparecida Teixeira, Marcelo Nicolas Muscara, Katia Regina Perez, Iolanda Midea Cuccovia, Alvaro Pacheco-Silva, Giselle Martins Gonçalves, Niels Olsen Saraiva Camara

ABSTRACT

Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4(+) T-cell activity. We propose that in renal fibrogenesis, M2 macrophages are recruited and activated in a T helper subset 2 cell (T(H)2)-prone inflammatory milieu in a MyD88-dependent manner. Mice submitted to unilateral ureteral ligation (UUO) demonstrated an increase in macrophage infiltration with collagen deposition after 7 d. Conversely, TLR2, TLR4 and MyD88 knockout (KO) mice had an improved renal function together with diminished T(H)2 cytokine production and decreased fibrosis formation. Moreover, TLR2, TLR4 and MyD88 KO animals exhibited less M2 macrophage infiltration, namely interleukin (IL)-10(+) and CD206(+) CD11b(high) cells, at 7 d after surgery. We evaluated the role of a T(H)2 cytokine in this context, and observed that the absence of IL-4 was associated with better renal function, decreased IL-13 and TGF-β levels, reduced arginase activity and a decrease in fibrosis formation when compared with IL-12 KO and wild-type (WT) animals. Indeed, the better renal outcomes and the decreased fibrosis formation were restricted to the deficiency of IL-4 in the hematopoietic compartment. Finally, macrophage depletion, rather than the absence of T cells, led to reduced lesions of the glomerular filtration barrier and decreased collagen deposition. These results provide evidence that future therapeutic strategies against renal fibrosis should be accompanied by the modulation of the M1:M2 and T(H)1:T(H)2 balance, as T(H)2 and M2 cells are predictive of fibrosis toward mechanisms that are sensed by innate immune response and triggered in a MyD88-dependent pathway. More... »

PAGES

1231-1239

Identifiers

URI

http://scigraph.springernature.com/pub.10.2119/molmed.2012.00131

DOI

http://dx.doi.org/10.2119/molmed.2012.00131

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1068965536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22777483


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