Proteomic Analysis Permits the Identification of New Biomarkers of Arterial Wall Remodeling in Hypertension View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-07

AUTHORS

Sandrine Delbosc, Mounsif Haloui, Liliane Louedec, Morgan Dupuis, Myriam Cubizolles, Vladimir N. Podust, Eric T. Fung, Jean-Baptiste Michel, Olivier Meilhac

ABSTRACT

Hypertension represents one of the main risk factors for vascular diseases. Genetic susceptibility may influence the rate of its development and the associated vascular remodeling. To explore markers of hypertension-related morbidity, we have used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to study changes in proteins released by the aorta of two rat strains with different susceptibilities to hypertension. Fischer and Brown Norway (BN) rats were divided into a control group and a group receiving low-dose N(Omega)-nitro-L-arginine methyl ester (L-NAME), a hypertensive drug, interfering with endothelial function. In spite of a significant elevation of blood pressure in both strains in response to L-NAME, BN rats exhibited a lower vascular remodeling in response to hypertension. Proteomic analysis of secreted aortic proteins by SELDI-TOF MS allowed detection of four mass-to-charge ratio (m/z) peaks whose corresponding proteins were identified as ubiquitin, smooth muscle (SM) 22alpha, thymosin beta4, and C-terminal fragment of filamin A, differentially secreted in Fischer rats in response to L-NAME. We have confirmed a strain-dependent difference in susceptibility to L-NAME-induced hypertension between BN and Fischer rats. The greater susceptibility of Fischer rats is associated with aortic wall hypertrophic remodeling, reflected by increased aortic secretion of four identified biomarkers. Similar variations in one of them, SM22alpha, also were observed in plasma, suggesting that this marker could be used to assess vascular damage induced by hypertension. More... »

PAGES

383-394

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.2119/2008-00030.delbosc

DOI

http://dx.doi.org/10.2119/2008-00030.delbosc

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1068965080

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18496584


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NG-Nitroarginine Methyl Ester", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasminogen Activator Inhibitor 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred BN", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred F344", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Regeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Renal Artery", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 H\u00f4pital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delbosc", 
        "givenName": "Sandrine", 
        "id": "sg:person.0632710443.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632710443.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 H\u00f4pital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haloui", 
        "givenName": "Mounsif", 
        "id": "sg:person.0653775416.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653775416.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 H\u00f4pital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Louedec", 
        "givenName": "Liliane", 
        "id": "sg:person.01015252243.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015252243.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French Institute of Health and Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Inserm, U525, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dupuis", 
        "givenName": "Morgan", 
        "id": "sg:person.0757071322.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757071322.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ciphergen Biosystems Inc., Fremont, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cubizolles", 
        "givenName": "Myriam", 
        "id": "sg:person.01004117350.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004117350.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ciphergen Biosystems Inc., Fremont, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Podust", 
        "givenName": "Vladimir N.", 
        "id": "sg:person.01023361131.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023361131.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ciphergen Biosystems Inc., Fremont, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fung", 
        "givenName": "Eric T.", 
        "id": "sg:person.01167024456.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167024456.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 H\u00f4pital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michel", 
        "givenName": "Jean-Baptiste", 
        "id": "sg:person.01173677740.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173677740.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 H\u00f4pital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meilhac", 
        "givenName": "Olivier", 
        "id": "sg:person.01011336140.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011336140.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m403370200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000002114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.biochem.67.1.425", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004475027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200109000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004777996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00004872-200109000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004777996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m506303200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011651974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m506303200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011651974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.34.4.546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013661459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2002.6678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018068133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000220108.97208.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000220108.97208.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000220108.97208.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2003.09.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022965853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000138850.72900.fe", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023479117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc0402.102951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024434687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024454611", 
          "https://doi.org/10.1038/ki.1986.101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.51.3.280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027107294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.101.3.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027678945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.18.6.922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030908079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(04)00220-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031493123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.2001.21.4.1336-1344.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032823789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2003-04-1015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033531531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.25.8.1666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034507506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200300389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035401272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.20505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037551625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci119198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044630000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.36.1.103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044703884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000136814.87170.b1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045120538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2005.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048266081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.00374.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049183404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hy0102.099025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050221075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jchromb.2004.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050427667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.22.3.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050799273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1357-2725(00)00087-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052035582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hh0801.090193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052156917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(96)00220-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054579454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00724.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063194412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.hyp.28.3.361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063339480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.2001.91.2.953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074850668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075017889", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075096119", 
          "https://doi.org/10.1007/bf03402009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/mar0205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107071511"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-07", 
    "datePublishedReg": "2008-07-01", 
    "description": "Hypertension represents one of the main risk factors for vascular diseases. Genetic susceptibility may influence the rate of its development and the associated vascular remodeling. To explore markers of hypertension-related morbidity, we have used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to study changes in proteins released by the aorta of two rat strains with different susceptibilities to hypertension. Fischer and Brown Norway (BN) rats were divided into a control group and a group receiving low-dose N(Omega)-nitro-L-arginine methyl ester (L-NAME), a hypertensive drug, interfering with endothelial function. In spite of a significant elevation of blood pressure in both strains in response to L-NAME, BN rats exhibited a lower vascular remodeling in response to hypertension. Proteomic analysis of secreted aortic proteins by SELDI-TOF MS allowed detection of four mass-to-charge ratio (m/z) peaks whose corresponding proteins were identified as ubiquitin, smooth muscle (SM) 22alpha, thymosin beta4, and C-terminal fragment of filamin A, differentially secreted in Fischer rats in response to L-NAME. We have confirmed a strain-dependent difference in susceptibility to L-NAME-induced hypertension between BN and Fischer rats. The greater susceptibility of Fischer rats is associated with aortic wall hypertrophic remodeling, reflected by increased aortic secretion of four identified biomarkers. Similar variations in one of them, SM22alpha, also were observed in plasma, suggesting that this marker could be used to assess vascular damage induced by hypertension.", 
    "genre": "research_article", 
    "id": "sg:pub.10.2119/2008-00030.delbosc", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1113628", 
        "issn": [
          "1076-1551", 
          "1528-3658"
        ], 
        "name": "Molecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7-8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Proteomic Analysis Permits the Identification of New Biomarkers of Arterial Wall Remodeling in Hypertension", 
    "pagination": "383-394", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7b4c740418fb7476fb343aa6ec5bcfbac5d702e0b541e7169979142c76339f8f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18496584"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9501023"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.2119/2008-00030.delbosc"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1068965080"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.2119/2008-00030.delbosc", 
      "https://app.dimensions.ai/details/publication/pub.1068965080"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117106_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.2119%2F2008-00030.Delbosc"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2119/2008-00030.delbosc'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2119/2008-00030.delbosc'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2119/2008-00030.delbosc'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.2119/2008-00030.delbosc'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      82 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.2119/2008-00030.delbosc schema:about N06eb252c70784065a0b9508d07fa2e1a
2 N16eeec1539d448e8955e045bd7c2c088
3 N3603266e8ada4dd0a990ff25e01768c2
4 N608e4e825f1547f2ba34d5a16d91f817
5 N623c160397814bf3aeab9d0931641b85
6 N69d3cf058e6b4937b65bc62cb0f032de
7 N6a64aec9f5b4432695a916e8343db212
8 N72af1accc9a04a46b61c23b66ceacffa
9 N77c963be760a46bea4d966062ea5a712
10 N7b4adff16e2f4a6595878ae82d9621e2
11 Na2f9594863794dc3b5c64ce488f74403
12 Nb84afa2a1b764d9895724676113d1283
13 Ncab795e11fb947bdb44cc47f7606b4a6
14 Ncf39c5a8a8104d97a51a95d8adfbd235
15 Nf102cac3a5b0468084783eddb3a00ad5
16 Nf5505e5d71b046a294eac3b277417cb4
17 anzsrc-for:11
18 anzsrc-for:1102
19 schema:author N723a6cb084d84e88b8f0231bfab1747f
20 schema:citation sg:pub.10.1007/bf03402009
21 sg:pub.10.1038/ki.1986.101
22 https://app.dimensions.ai/details/publication/pub.1075017889
23 https://doi.org/10.1002/hep.20505
24 https://doi.org/10.1002/pmic.200300389
25 https://doi.org/10.1006/bbrc.2002.6678
26 https://doi.org/10.1016/j.cardiores.2003.09.033
27 https://doi.org/10.1016/j.gde.2005.04.001
28 https://doi.org/10.1016/j.jchromb.2004.11.012
29 https://doi.org/10.1016/s0008-6363(96)00220-9
30 https://doi.org/10.1016/s0014-5793(04)00220-0
31 https://doi.org/10.1016/s1357-2725(00)00087-x
32 https://doi.org/10.1074/jbc.m403370200
33 https://doi.org/10.1074/jbc.m506303200
34 https://doi.org/10.1097/00004872-200109000-00008
35 https://doi.org/10.1128/mcb.2001.21.4.1336-1344.2001
36 https://doi.org/10.1146/annurev.biochem.67.1.425
37 https://doi.org/10.1152/ajpheart.00724.2001
38 https://doi.org/10.1152/ajprenal.00374.2004
39 https://doi.org/10.1152/jappl.2001.91.2.953
40 https://doi.org/10.1161/01.atv.0000220108.97208.67
41 https://doi.org/10.1161/01.atv.18.6.922
42 https://doi.org/10.1161/01.cir.0000136814.87170.b1
43 https://doi.org/10.1161/01.cir.0000138850.72900.fe
44 https://doi.org/10.1161/01.cir.101.3.264
45 https://doi.org/10.1161/01.hyp.22.3.380
46 https://doi.org/10.1161/01.hyp.28.3.361
47 https://doi.org/10.1161/01.hyp.34.4.546
48 https://doi.org/10.1161/01.hyp.36.1.103
49 https://doi.org/10.1161/01.res.51.3.280
50 https://doi.org/10.1161/01.str.25.8.1666
51 https://doi.org/10.1161/hc0402.102951
52 https://doi.org/10.1161/hh0801.090193
53 https://doi.org/10.1161/hy0102.099025
54 https://doi.org/10.1172/jci119198
55 https://doi.org/10.1182/blood-2003-04-1015
56 https://doi.org/10.2144/mar0205
57 schema:datePublished 2008-07
58 schema:datePublishedReg 2008-07-01
59 schema:description Hypertension represents one of the main risk factors for vascular diseases. Genetic susceptibility may influence the rate of its development and the associated vascular remodeling. To explore markers of hypertension-related morbidity, we have used surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry to study changes in proteins released by the aorta of two rat strains with different susceptibilities to hypertension. Fischer and Brown Norway (BN) rats were divided into a control group and a group receiving low-dose N(Omega)-nitro-L-arginine methyl ester (L-NAME), a hypertensive drug, interfering with endothelial function. In spite of a significant elevation of blood pressure in both strains in response to L-NAME, BN rats exhibited a lower vascular remodeling in response to hypertension. Proteomic analysis of secreted aortic proteins by SELDI-TOF MS allowed detection of four mass-to-charge ratio (m/z) peaks whose corresponding proteins were identified as ubiquitin, smooth muscle (SM) 22alpha, thymosin beta4, and C-terminal fragment of filamin A, differentially secreted in Fischer rats in response to L-NAME. We have confirmed a strain-dependent difference in susceptibility to L-NAME-induced hypertension between BN and Fischer rats. The greater susceptibility of Fischer rats is associated with aortic wall hypertrophic remodeling, reflected by increased aortic secretion of four identified biomarkers. Similar variations in one of them, SM22alpha, also were observed in plasma, suggesting that this marker could be used to assess vascular damage induced by hypertension.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf Nd5e894ac4ae843bca2d3ebdc8776db55
64 Nf6a42e5557e14ebfb008322f02138fb0
65 sg:journal.1113628
66 schema:name Proteomic Analysis Permits the Identification of New Biomarkers of Arterial Wall Remodeling in Hypertension
67 schema:pagination 383-394
68 schema:productId N87adddacaacc4c89bfe937965b4c7da2
69 N899740506d514755ae3a6189fe52d5d9
70 N8ca2708b97464ad293a4e6998f5f03ed
71 N92de3c6dad75434291d616338df5ce8a
72 Nf6ee0d8ce52348d39db26455c1bbf04b
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965080
74 https://doi.org/10.2119/2008-00030.delbosc
75 schema:sdDatePublished 2019-04-11T14:18
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N85631b96a4554d77af098316d7af814f
78 schema:url https://link.springer.com/10.2119%2F2008-00030.Delbosc
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N06eb252c70784065a0b9508d07fa2e1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Rats
84 rdf:type schema:DefinedTerm
85 N097d64a462834f8bbd07c97a83cfaf0a schema:name Ciphergen Biosystems Inc., Fremont, California, USA
86 rdf:type schema:Organization
87 N16eeec1539d448e8955e045bd7c2c088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Proteomics
89 rdf:type schema:DefinedTerm
90 N1a5484e5a2e3448f92c83de2e2b08292 schema:name Ciphergen Biosystems Inc., Fremont, California, USA
91 rdf:type schema:Organization
92 N200517edb1ae4662879f1a6d90380716 rdf:first sg:person.01004117350.44
93 rdf:rest Na35ab92d560a4676850412a47ff85e3b
94 N3603266e8ada4dd0a990ff25e01768c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Proteome
96 rdf:type schema:DefinedTerm
97 N40244d53ed144dfe91baf87790af1678 schema:name Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 Hôpital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France
98 rdf:type schema:Organization
99 N45f15c9f531546daaccbf4028570acd3 schema:name Ciphergen Biosystems Inc., Fremont, California, USA
100 rdf:type schema:Organization
101 N51efc5beb1ca47f29635e774720824db rdf:first sg:person.0653775416.57
102 rdf:rest Nd1c3c25cf03640c3b3bd13b28b65fb1a
103 N608e4e825f1547f2ba34d5a16d91f817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Endothelium, Vascular
105 rdf:type schema:DefinedTerm
106 N623c160397814bf3aeab9d0931641b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Survival Analysis
108 rdf:type schema:DefinedTerm
109 N69d3cf058e6b4937b65bc62cb0f032de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Biomarkers
111 rdf:type schema:DefinedTerm
112 N6a64aec9f5b4432695a916e8343db212 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name NG-Nitroarginine Methyl Ester
114 rdf:type schema:DefinedTerm
115 N6f25246352df4ecbada0bd2d26e9f199 schema:name Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 Hôpital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France
116 rdf:type schema:Organization
117 N723a6cb084d84e88b8f0231bfab1747f rdf:first sg:person.0632710443.90
118 rdf:rest N51efc5beb1ca47f29635e774720824db
119 N72af1accc9a04a46b61c23b66ceacffa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Hypertension
121 rdf:type schema:DefinedTerm
122 N77c963be760a46bea4d966062ea5a712 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Plasminogen Activator Inhibitor 1
124 rdf:type schema:DefinedTerm
125 N7b4adff16e2f4a6595878ae82d9621e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Regeneration
127 rdf:type schema:DefinedTerm
128 N7e50a0d52df94abba9e4757ff4cfcf5d rdf:first sg:person.01167024456.35
129 rdf:rest Nf3d030513fbe45478c3890df05a72e6c
130 N84864bc6e0a64a9282b7d3b3abdee4fc schema:name Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 Hôpital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France
131 rdf:type schema:Organization
132 N85631b96a4554d77af098316d7af814f schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 N87adddacaacc4c89bfe937965b4c7da2 schema:name pubmed_id
135 schema:value 18496584
136 rdf:type schema:PropertyValue
137 N899740506d514755ae3a6189fe52d5d9 schema:name dimensions_id
138 schema:value pub.1068965080
139 rdf:type schema:PropertyValue
140 N8ca2708b97464ad293a4e6998f5f03ed schema:name readcube_id
141 schema:value 7b4c740418fb7476fb343aa6ec5bcfbac5d702e0b541e7169979142c76339f8f
142 rdf:type schema:PropertyValue
143 N92de3c6dad75434291d616338df5ce8a schema:name nlm_unique_id
144 schema:value 9501023
145 rdf:type schema:PropertyValue
146 N9bc3c9d840d244c5a4efb75eefe38759 schema:name Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 Hôpital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France
147 rdf:type schema:Organization
148 N9bc6c95a83ff4fe5983aa9da81b1d7df rdf:first sg:person.01011336140.60
149 rdf:rest rdf:nil
150 Na2f9594863794dc3b5c64ce488f74403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Animals
152 rdf:type schema:DefinedTerm
153 Na35ab92d560a4676850412a47ff85e3b rdf:first sg:person.01023361131.02
154 rdf:rest N7e50a0d52df94abba9e4757ff4cfcf5d
155 Na700365d2c094886b39d2e50b94d51a5 rdf:first sg:person.0757071322.88
156 rdf:rest N200517edb1ae4662879f1a6d90380716
157 Nb84afa2a1b764d9895724676113d1283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Aorta
159 rdf:type schema:DefinedTerm
160 Ncab795e11fb947bdb44cc47f7606b4a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats, Inbred F344
162 rdf:type schema:DefinedTerm
163 Ncf39c5a8a8104d97a51a95d8adfbd235 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Rats, Inbred BN
165 rdf:type schema:DefinedTerm
166 Nd1c3c25cf03640c3b3bd13b28b65fb1a rdf:first sg:person.01015252243.31
167 rdf:rest Na700365d2c094886b39d2e50b94d51a5
168 Nd5e894ac4ae843bca2d3ebdc8776db55 schema:volumeNumber 14
169 rdf:type schema:PublicationVolume
170 Nf102cac3a5b0468084783eddb3a00ad5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Hemodynamics
172 rdf:type schema:DefinedTerm
173 Nf3d030513fbe45478c3890df05a72e6c rdf:first sg:person.01173677740.54
174 rdf:rest N9bc6c95a83ff4fe5983aa9da81b1d7df
175 Nf5505e5d71b046a294eac3b277417cb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Renal Artery
177 rdf:type schema:DefinedTerm
178 Nf6a42e5557e14ebfb008322f02138fb0 schema:issueNumber 7-8
179 rdf:type schema:PublicationIssue
180 Nf6ee0d8ce52348d39db26455c1bbf04b schema:name doi
181 schema:value 10.2119/2008-00030.delbosc
182 rdf:type schema:PropertyValue
183 Nf8cf8f47fd164fc4a743c769975c8bd4 schema:name Inserm, U698: Hematology, Bio-engineering and Cardiovascular Remodeling, CHU X Bichat; University Paris 7 Hôpital Xavier Bichat, 46 Rue Henri Huchard, 75877, Paris, cedex 18, France
184 rdf:type schema:Organization
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
189 schema:name Cardiorespiratory Medicine and Haematology
190 rdf:type schema:DefinedTerm
191 sg:journal.1113628 schema:issn 1076-1551
192 1528-3658
193 schema:name Molecular Medicine
194 rdf:type schema:Periodical
195 sg:person.01004117350.44 schema:affiliation N1a5484e5a2e3448f92c83de2e2b08292
196 schema:familyName Cubizolles
197 schema:givenName Myriam
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004117350.44
199 rdf:type schema:Person
200 sg:person.01011336140.60 schema:affiliation Nf8cf8f47fd164fc4a743c769975c8bd4
201 schema:familyName Meilhac
202 schema:givenName Olivier
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011336140.60
204 rdf:type schema:Person
205 sg:person.01015252243.31 schema:affiliation N9bc3c9d840d244c5a4efb75eefe38759
206 schema:familyName Louedec
207 schema:givenName Liliane
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015252243.31
209 rdf:type schema:Person
210 sg:person.01023361131.02 schema:affiliation N097d64a462834f8bbd07c97a83cfaf0a
211 schema:familyName Podust
212 schema:givenName Vladimir N.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023361131.02
214 rdf:type schema:Person
215 sg:person.01167024456.35 schema:affiliation N45f15c9f531546daaccbf4028570acd3
216 schema:familyName Fung
217 schema:givenName Eric T.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167024456.35
219 rdf:type schema:Person
220 sg:person.01173677740.54 schema:affiliation N6f25246352df4ecbada0bd2d26e9f199
221 schema:familyName Michel
222 schema:givenName Jean-Baptiste
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173677740.54
224 rdf:type schema:Person
225 sg:person.0632710443.90 schema:affiliation N40244d53ed144dfe91baf87790af1678
226 schema:familyName Delbosc
227 schema:givenName Sandrine
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632710443.90
229 rdf:type schema:Person
230 sg:person.0653775416.57 schema:affiliation N84864bc6e0a64a9282b7d3b3abdee4fc
231 schema:familyName Haloui
232 schema:givenName Mounsif
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653775416.57
234 rdf:type schema:Person
235 sg:person.0757071322.88 schema:affiliation https://www.grid.ac/institutes/grid.7429.8
236 schema:familyName Dupuis
237 schema:givenName Morgan
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757071322.88
239 rdf:type schema:Person
240 sg:pub.10.1007/bf03402009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075096119
241 https://doi.org/10.1007/bf03402009
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/ki.1986.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024454611
244 https://doi.org/10.1038/ki.1986.101
245 rdf:type schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1075017889 schema:CreativeWork
247 https://doi.org/10.1002/hep.20505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037551625
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/pmic.200300389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035401272
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1006/bbrc.2002.6678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018068133
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.cardiores.2003.09.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022965853
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.gde.2005.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048266081
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.jchromb.2004.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050427667
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0008-6363(96)00220-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054579454
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/s0014-5793(04)00220-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031493123
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s1357-2725(00)00087-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052035582
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1074/jbc.m403370200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000002114
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1074/jbc.m506303200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011651974
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1097/00004872-200109000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004777996
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1128/mcb.2001.21.4.1336-1344.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032823789
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1146/annurev.biochem.67.1.425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004475027
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1152/ajpheart.00724.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063194412
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1152/ajprenal.00374.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049183404
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1152/jappl.2001.91.2.953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074850668
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1161/01.atv.0000220108.97208.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281875
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1161/01.atv.18.6.922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030908079
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1161/01.cir.0000136814.87170.b1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045120538
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1161/01.cir.0000138850.72900.fe schema:sameAs https://app.dimensions.ai/details/publication/pub.1023479117
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1161/01.cir.101.3.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027678945
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1161/01.hyp.22.3.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050799273
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1161/01.hyp.28.3.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063339480
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1161/01.hyp.34.4.546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013661459
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/01.hyp.36.1.103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044703884
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1161/01.res.51.3.280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027107294
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1161/01.str.25.8.1666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034507506
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1161/hc0402.102951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024434687
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1161/hh0801.090193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052156917
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1161/hy0102.099025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050221075
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1172/jci119198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044630000
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1182/blood-2003-04-1015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033531531
312 rdf:type schema:CreativeWork
313 https://doi.org/10.2144/mar0205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107071511
314 rdf:type schema:CreativeWork
315 https://www.grid.ac/institutes/grid.7429.8 schema:alternateName French Institute of Health and Medical Research
316 schema:name Inserm, U525, Paris, France
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...