Matriptase: Potent Proteolysis on the Cell Surface View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-01

AUTHORS

Karin List, Thomas H. Bugge, Roman Szabo

ABSTRACT

Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. Activation of the matriptase zymogen requires sequential N-terminal cleavage, activation site autocleavage, and transient association with HAI-1. Matriptase has an essential physiological role in profilaggrin processing, corneocyte maturation, and lipid matrix formation associated with terminal differentiation of the oral epithelium and the epidermis, and is also critical for hair follicle growth. Matriptase and HAI expression are frequently dysregulated in human cancer, and matriptase expression that is unopposed by HAI-1 potently promotes carcinogenesis and metastatic dissemination in animal models. More... »

PAGES

1-7

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.2119/2006-00022.list

    DOI

    http://dx.doi.org/10.2119/2006-00022.list

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1068964928

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16838070


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.2119/2006-00022.list'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.2119/2006-00022.list'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.2119/2006-00022.list'

    RDF/XML is a standard XML format for linked data.

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