Outcome after epilepsy surgery in children with MRI-negative non-idiopathic focal epilepsies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Thomas Bast

ABSTRACT

MRI is one of the most important diagnostic tools in the presurgical evaluation of patients suffering from pharmaco-refractory focal epilepsies. Presence of a lesion on MRI influences both diagnostic classification as well as selection for surgery; however, the implications for MRI-negative cases are far from well defined for such patients. Detection of potentially epileptogenic lesions depends on the techniques applied (high-field MRI, post-processing, etc.) and the experience of the neuroradiologist. The proportion of MRI-negative patients in reported epilepsy surgery cohorts ranges from 16 to 47%. Most MRI-negative patients undergo invasive long-term EEG recordings before a final decision regarding resection is possible. Post-operative seizure freedom rates, with few exceptions, range from 40 to 50%. Selection of surgical candidates and post-operative outcomes may be improved by recent developments in structural and functional imaging techniques and multimodal approaches. This report gives an overview of outcomes after epilepsy surgery in MR-negative patients with a focus on children. Issues regarding definitions, the role of established and recently introduced diagnostic tools, and the question of how outcome might be improved in the future are discussed. More... »

PAGES

105-113

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1684/epd.2013.0580

DOI

http://dx.doi.org/10.1684/epd.2013.0580

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1078744365

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23771650


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