Development of monoclonal gammopathy under biotherapy in psoriasis: a French multicenter retrospective study View Full Text


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Article Info

DATE

2016-01

AUTHORS

Anne-Laure Liegeon, Emmanuel Mahe, Edouard Begon, Claire Poreaux, Annick Barbaud, Eric Esteve, Nathalie Quiles-Tsimaratos, Martine Avenel-Audran, Amélie Schoeffler, Laure Mery-Bossard, Christine Pauwels, Céline Girard, Hervé Maillard, Dominique Barthelme, Claire Bernier, Guillaume Chaby, Ziad Reguiai, Phi Linh Nguyen-Thi, François Maccari, Jean-Luc Schmutz

ABSTRACT

BackgroundBiotherapies or targeted therapies are fairly new treatments indicated for moderate to severe psoriasis. The side effects appear to be mainly infectious or cancerous. The role of biotherapies in the development of a pre-cancerous condition, monoclonal gammopathy of undetermined significance (MGUS), has recently been debated in the literature.ObjectivesTo evaluate the incidence of MGUS in psoriasis patients treated with biotherapy.Materials and MethodsThis study was a French multicenter retrospective study carried out through the French multicenter study group RESOPSO. Data on the results of serum protein electrophoreses performed before and within at least six months after the start of the biotherapy were collected. Demographic data, medical history, and psoriasis treatment history were specified.ResultsFour hundred and forty three patients were eligible for inclusion. Of these, three presented with monoclonal gammopathy for which the assessment was in favor of MGUS. The average treatment period was 19.7 months. Six patients presented withMGUSprior to the treatment. These patients’ immunoglobulin levels remained stable, with an average remission of 24 months. Only psoriatic rheumatism appeared to be statistically linked to MGUS.ConclusionThe incidence and frequency ofMGUSin psoriasis patients treated with biotherapy do not appear to increase relative to the general population. More... »

PAGES

75-81

References to SciGraph publications

  • 1987-01. Monoclonal IgG gammopathy in a case of pustular psoriasis in BLUT ZEITSCHRIFT FÜR DIE GESAMTE BLUTFORSCHUNG
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    URI

    http://scigraph.springernature.com/pub.10.1684/ejd.2015.2700

    DOI

    http://dx.doi.org/10.1684/ejd.2015.2700

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020998322

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26878712


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    17 schema:description BackgroundBiotherapies or targeted therapies are fairly new treatments indicated for moderate to severe psoriasis. The side effects appear to be mainly infectious or cancerous. The role of biotherapies in the development of a pre-cancerous condition, monoclonal gammopathy of undetermined significance (MGUS), has recently been debated in the literature.ObjectivesTo evaluate the incidence of MGUS in psoriasis patients treated with biotherapy.Materials and MethodsThis study was a French multicenter retrospective study carried out through the French multicenter study group RESOPSO. Data on the results of serum protein electrophoreses performed before and within at least six months after the start of the biotherapy were collected. Demographic data, medical history, and psoriasis treatment history were specified.ResultsFour hundred and forty three patients were eligible for inclusion. Of these, three presented with monoclonal gammopathy for which the assessment was in favor of MGUS. The average treatment period was 19.7 months. Six patients presented withMGUSprior to the treatment. These patients’ immunoglobulin levels remained stable, with an average remission of 24 months. Only psoriatic rheumatism appeared to be statistically linked to MGUS.ConclusionThe incidence and frequency ofMGUSin psoriasis patients treated with biotherapy do not appear to increase relative to the general population.
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