Déficits en protéines du complément et pathologies humaines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014

AUTHORS

Jérémie Rosain, Stéphanie Ngo, Pauline Bordereau, Nelly Poulain, Stéphane Roncelin, Paula Vieira Martins, Marie-Agnès Dragon-Durey, Véronique Frémeaux-Bacchi

ABSTRACT

The complement system is a complex system involving serum and membrane proteins interacting in a regulated manner. The complement system plays a major role in antibacterial immunity, in inflammation, and in immune complex processing. Therefore, deficiencies in complement proteins are associated with increased susceptibility to bacterial infections and autoimmune diseases. These deficiencies can be inherited or acquired. Most of them can be screened by simple laboratory tests but require a diagnosis in a specialized laboratory. All sequences of complement genes are known, and the discovery of a deficiency must lead to genetic testing. The discovery of a congenital deficiency requires a familial study and a prophylaxis. In this article, we review the complement cascade, the laboratory tests to explore it, and the main diseases associated with complement deficiencies. More... »

PAGES

271-280

Identifiers

URI

http://scigraph.springernature.com/pub.10.1684/abc.2014.0961

DOI

http://dx.doi.org/10.1684/abc.2014.0961

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047551794

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24876138


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182 Immunologie biologique, Hôpital européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
183 schema:name Immunologie biologique, Hôpital européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France, Inserm UMR_S1138, Centre de recherche des Cordeliers, Paris, France.
184 Immunologie biologique, Hôpital européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.
185 rdf:type schema:Organization
 




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