Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05-03

AUTHORS

Qi Yu, En-qi Liu, Si-hai Zhao, Ya-feng Li, Yan-li Wang, Yu-long Chen, Ke-na Wei, Bing-qiao Huang, Jian-lin Fan, Peng-hui Yang

ABSTRACT

ObjectiveTo assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in Chinese population, we performed a meta-analysis in this paper.MethodsWe searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsThe literature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89–1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09–1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers.ConclusionsIn the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the Chinese population. More... »

PAGES

342-347

Identifiers

URI

http://scigraph.springernature.com/pub.10.1631/jzus.b1100264

DOI

http://dx.doi.org/10.1631/jzus.b1100264

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022595809

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22556171


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