Characterization of a novel impurity in bulk drug of lisinopril by multidimensional NMR technique View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-04

AUTHORS

Dan-hua Wang, Sai-feng Pei, Ming-hua Zhou, Cui-rong Sun, Yuan-jiang Pan

ABSTRACT

During the routine impurity profile of lisinopril bulk drug by HPLC (high-performance liquid chromatography), a potential impurity was detected. Using multidimensional NMR (nuclear magnetic resonance) technique, the trace-level impurity was unambiguously identified to be 2-(-2-oxo-azocan-3-ylamino)-4-phenyl-butyric acid after isolation from lisinopril bulk drug by semi-preparative HPLC. Formation of the impurity was also discussed. To our knowledge, this is a novel impurity and not reported elsewhere. More... »

PAGES

310-313

References to SciGraph publications

  • 1996-10. Lisinopril in DRUGS
  • 2000-05. Lisinopril in DRUGS
  • 1988-06. Lisinopril in DRUGS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1631/jzus.2006.b0310

    DOI

    http://dx.doi.org/10.1631/jzus.2006.b0310

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032142682

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16532534


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