Leucopenia e trombocitopenia induzidas por etanercepte: relato de dois casos e revisão da literatura View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Valderílio Feijó Azevedo, Marília Barreto Gameiro Silva, Débora Karine Marinello, Felipe Dunin dos Santos, Guilherme Barreto Gameiro Silva

ABSTRACT

Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of various cellular types involved in immune response through expression of several other cytokines, it is possible that the use of its inhibitors may cause cytopenia. We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes. More... »

PAGES

110-112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1590/s0482-50042012000100011

DOI

http://dx.doi.org/10.1590/s0482-50042012000100011

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040201161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22286650


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