Ontology type: schema:ScholarlyArticle Open Access: True
2011-08
AUTHORSIzabella T. Silva, Thiago Caon, Débora D. Lückemeyer, Freddy A. Ramos, Edisson Tello, Catalina Arévalo-Ferro, Eloir P. Schenkel, Carmenza Duque, Cláudia M. O. Simões
ABSTRACTThe exploration of marine environment represents a promising strategy in the search for new active antiviral compounds. The isolation and characterization of the nucleosides spongothymidine and spongouridine from the sponge Cryptotethia crypta used as models for the synthesis of ara-A (vidarabine), that has been used therapeutically against herpetic encephalitis, was the most important contribution since the late 1970s. This paper describes the in vitro antiviral evaluation of 26 organic extracts obtained from eleven octocoral species and fifteen marine sponges. Cytotoxicity was evaluated on Vero cells by MTT assay and the antiviral activity was tested against Herpes Simplex Virus type 1 (HSV-1, KOS strain) by plaque number reduction assay. Results were expressed as 50% cytotoxic (CC50) and 50% inhibitory (IC50) concentrations, respectively, in order to calculate the selectivity index (SI= CC50/IC50) of each extract. Among the tested marine octocoral species, only three extracts showed antiviral activity, but with low selectivity indices (<3.0). Among the tested marine sponges, eight extracts showed SI values higher than 2.0, and three can be considered promising (Aka cachacrouense, Niphates erecta and Dragmacidon reticulatum) with SI values of 5.0, 8.0 and 11.7, respectively, meriting complementary studies in order to identify the bioactive components of these sponge extracts, which are in course now. More... »
PAGES608-614
http://scigraph.springernature.com/pub.10.1590/s0102-695x2011005000094
DOIhttp://dx.doi.org/10.1590/s0102-695x2011005000094
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1032231293
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Microbiology",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil"
],
"type": "Organization"
},
"familyName": "Silva",
"givenName": "Izabella T.",
"id": "sg:person.0625004532.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625004532.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil"
],
"type": "Organization"
},
"familyName": "Caon",
"givenName": "Thiago",
"id": "sg:person.01334740201.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334740201.71"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil"
],
"type": "Organization"
},
"familyName": "L\u00fcckemeyer",
"givenName": "D\u00e9bora D.",
"id": "sg:person.01147136663.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147136663.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia",
"id": "http://www.grid.ac/institutes/grid.10689.36",
"name": [
"Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia"
],
"type": "Organization"
},
"familyName": "Ramos",
"givenName": "Freddy A.",
"id": "sg:person.01070351531.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070351531.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia",
"id": "http://www.grid.ac/institutes/grid.10689.36",
"name": [
"Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia"
],
"type": "Organization"
},
"familyName": "Tello",
"givenName": "Edisson",
"id": "sg:person.01102217675.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102217675.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universidad Nacional de Colombia, Departamento de Biolog\u00eda, Colombia",
"id": "http://www.grid.ac/institutes/grid.10689.36",
"name": [
"Universidad Nacional de Colombia, Departamento de Biolog\u00eda, Colombia"
],
"type": "Organization"
},
"familyName": "Ar\u00e9valo-Ferro",
"givenName": "Catalina",
"id": "sg:person.01013356354.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013356354.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Brazil"
],
"type": "Organization"
},
"familyName": "Schenkel",
"givenName": "Eloir P.",
"id": "sg:person.01363247631.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363247631.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia",
"id": "http://www.grid.ac/institutes/grid.10689.36",
"name": [
"Universidad Nacional de Colombia, Departamento de Qu\u00edmica, Colombia"
],
"type": "Organization"
},
"familyName": "Duque",
"givenName": "Carmenza",
"id": "sg:person.01264561475.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264561475.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil",
"id": "http://www.grid.ac/institutes/grid.411237.2",
"name": [
"Santa Catarina, Universidade Federal de Santa Catarina, Departamento de Ci\u00eancias Farmac\u00eauticas, Laborat\u00f3rio de Virologia Aplicada, Brazil"
],
"type": "Organization"
},
"familyName": "Sim\u00f5es",
"givenName": "Cl\u00e1udia M. O.",
"id": "sg:person.011251515155.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011251515155.09"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf02522620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035740986",
"https://doi.org/10.1007/bf02522620"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/b:joec.0000030271.73629.26",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031249096",
"https://doi.org/10.1023/b:joec.0000030271.73629.26"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd2487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009068794",
"https://doi.org/10.1038/nrd2487"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1476-9255-6-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034484710",
"https://doi.org/10.1186/1476-9255-6-5"
],
"type": "CreativeWork"
}
],
"datePublished": "2011-08",
"datePublishedReg": "2011-08-01",
"description": "The exploration of marine environment represents a promising strategy in the search for new active antiviral compounds. The isolation and characterization of the nucleosides spongothymidine and spongouridine from the sponge Cryptotethia crypta used as models for the synthesis of ara-A (vidarabine), that has been used therapeutically against herpetic encephalitis, was the most important contribution since the late 1970s. This paper describes the in vitro antiviral evaluation of 26 organic extracts obtained from eleven octocoral species and fifteen marine sponges. Cytotoxicity was evaluated on Vero cells by MTT assay and the antiviral activity was tested against Herpes Simplex Virus type 1 (HSV-1, KOS strain) by plaque number reduction assay. Results were expressed as 50% cytotoxic (CC50) and 50% inhibitory (IC50) concentrations, respectively, in order to calculate the selectivity index (SI= CC50/IC50) of each extract. Among the tested marine octocoral species, only three extracts showed antiviral activity, but with low selectivity indices (<3.0). Among the tested marine sponges, eight extracts showed SI values higher than 2.0, and three can be considered promising (Aka cachacrouense, Niphates erecta and Dragmacidon reticulatum) with SI values of 5.0, 8.0 and 11.7, respectively, meriting complementary studies in order to identify the bioactive components of these sponge extracts, which are in course now.",
"genre": "article",
"id": "sg:pub.10.1590/s0102-695x2011005000094",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1126911",
"issn": [
"0102-695X",
"1981-528X"
],
"name": "Revista Brasileira de Farmacognosia",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "4",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"keywords": [
"antiviral activity",
"plaque number reduction",
"herpes simplex virus type 1",
"selectivity index",
"simplex virus type 1",
"virus type 1",
"active antiviral compounds",
"low selectivity index",
"herpetic encephalitis",
"antiviral evaluation",
"type 1",
"antiviral compounds",
"SI values",
"Vero cells",
"inhibitory concentration",
"MTT assay",
"bioactive components",
"promising strategy",
"extract",
"encephalitis",
"index",
"ara",
"spongouridine",
"activity",
"cytotoxic",
"spongothymidine",
"cytotoxicity",
"complementary studies",
"screening",
"organic extracts",
"assays",
"cells",
"sponge extracts",
"course",
"evaluation",
"sponges",
"study",
"number reduction",
"reduction",
"concentration",
"search",
"synthesis of ara",
"isolation",
"marine sponges",
"values",
"strategies",
"important contribution",
"organisms",
"results",
"compounds",
"late 1970s",
"crypta",
"components",
"exploration",
"model",
"species",
"synthesis",
"order",
"characterization",
"contribution",
"environment",
"marine organisms",
"Colombian Caribbean Sea",
"paper",
"marine environment",
"octocoral species",
"Sea",
"Caribbean Sea"
],
"name": "Antiherpes screening of marine organisms from Colombian Caribbean Sea",
"pagination": "608-614",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1032231293"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1590/s0102-695x2011005000094"
]
}
],
"sameAs": [
"https://doi.org/10.1590/s0102-695x2011005000094",
"https://app.dimensions.ai/details/publication/pub.1032231293"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:27",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_551.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1590/s0102-695x2011005000094"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1590/s0102-695x2011005000094'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1590/s0102-695x2011005000094'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1590/s0102-695x2011005000094'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1590/s0102-695x2011005000094'
This table displays all metadata directly associated to this object as RDF triples.
205 TRIPLES
22 PREDICATES
98 URIs
86 LITERALS
6 BLANK NODES