Drug–matrix interactions in nanostructured materials containing fluoxetine using sol-gel titanium oxide as a matrix View Full Text


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Article Info

DATE

2011-09-13

AUTHORS

Mayra González, Jacques Rieumont, Francois Figueras, Patricia Quintana

ABSTRACT

Titanium oxide matrix was prepared by sol-gel adding fluoxetine [Prozac (C 17 H 18 NF 3 O)] during the reaction of gelation. This nanostructured material was studied by Fourier transform infrared (FTIR) spectroscopy, N 2 adsorption, and x-ray diffraction to detect the interaction between the drug and the matrix. The complex nature of FTIR signals for the matrix and the drug did not allow observation of the interactions; however, using the density functional theory formalism, two stable complexes are suggested to be formed on the drug–matrix system. Both complexes are formed through H bond interactions involving the amine group in fluoxetine and the hydroxylated sites in titanium xerogel. They were found to be energetically stable and independent of the titanium model core cluster used in the calculations. More... »

PAGES

2871-2876

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1557/jmr.2011.266

DOI

http://dx.doi.org/10.1557/jmr.2011.266

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010908742


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