Mechanical properties and cytocompatibility of biomimetic hydroxyapatite-gelatin nanocomposites View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

Ching-Chang Ko, Michelle Oyen, Alison M. Fallgatter, Jin-Hong Kim, Jim Fricton, Wei-Shou Hu

ABSTRACT

A hydroxyapatite-gelatin nanocomposite system has been developed to resemble the composition and ultrastructure of natural bone for the application of tissue engineering. In the current study, variations in composition—content of gelatin and glutaraldehyde crosslinker—were examined in the context of mechanical properties and material biocompatibility. It was found that increasing the gelatin concentration resulted in a decreased hydroxyapatite crystal length and was associated with a slight increase in elastic modulus. Increases in gelatin and glutaraldehyde content were associated with increased material fracture toughness. Cellular biocompatibility tests, including cellular attachment and proliferation assays, were also used to assist in the process of optimizing gelatin and glutaraldehyde content. Optimized biomimetic nanocomposite materials for in vivo applications will likely be a compromise between the improved mechanical properties and decreased cytocompatibility associated with increased glutaraldehyde contents. More... »

PAGES

3090-3098

Identifiers

URI

http://scigraph.springernature.com/pub.10.1557/jmr.2006.0394

DOI

http://dx.doi.org/10.1557/jmr.2006.0394

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036008680


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