Paradigms of Notch Signaling in Mammals View Full Text


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Article Info

DATE

2005-11-01

AUTHORS

Alexis Dumortier, Anne Wilson, H. Robson MacDonald, Freddy Radtke

ABSTRACT

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal life. These proteins are involved in organogenesis during embryonic development as well as in the maintenance of homeostasis of self-renewing systems. The paradigms of Notch function, such as stem and progenitor cell maintenance, lineage specification mediated by binary cell fate decisions, and induction of terminal differentiation, were initially established in invertebrates and subsequently confirmed in mammals. Moreover, aberrant Notch signaling is linked to tumorigenesis. In this review, we discuss the origin of postulated Notch functions, give examples from different mammalian organ systems, and try to relate them to the hematopoietic system. More... »

PAGES

277-284

References to SciGraph publications

  • 2004-05-16. Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo in NATURE IMMUNOLOGY
  • 2001-12-20. Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning in ONCOGENE
  • 1995-06. Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta in NATURE
  • 2003-10-01. Glycosylation regulates Notch signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2000-11. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling in NATURE MEDICINE
  • 2004-11-15. Molecular mechanisms for morphogenesis of the central nervous system in mammals* in ANATOMICAL SCIENCE INTERNATIONAL
  • 2005-06. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells in NATURE
  • 2003-10. Osteoblastic cells regulate the haematopoietic stem cell niche in NATURE
  • 2002-08-19. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells in NATURE MEDICINE
  • 2005-06. Notch signals control the fate of immature progenitor cells in the intestine in NATURE
  • 2005-01-23. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance in NATURE IMMUNOLOGY
  • 2003-02-18. Notch1 functions as a tumor suppressor in mouse skin in NATURE GENETICS
  • 2002-04-22. Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells in NATURE IMMUNOLOGY
  • 2003-06-20. Differential response of primitive human CD34− and CD34+ hematopoietic cells to the Notch ligand Jagged-1 in LEUKEMIA
  • 2000-12. MAML1, a human homologue of Drosophila Mastermind, is a transcriptional co-activator for NOTCH receptors in NATURE GENETICS
  • 2002-09-01. γ-Secretase-mediated proteolysis in cell-surface-receptor signalling in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1532/ijh97.05099

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    http://dx.doi.org/10.1532/ijh97.05099

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035738061

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16298815


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