Targeting the osteoblast: approved and experimental anabolic agents for the treatment of osteoporosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-07

AUTHORS

Konstantinos A. Toulis, Athanasios D. Anastasilakis, Stergios A. Polyzos, Polyzois Makras

ABSTRACT

Targeting osteoblast may be the means of effectively improving both bone quality and mass, thus offering an intriguing alternative in the treatment of osteoporosis. Aside from injectable parathyroid hormone (PTH) and its novel preparations, PTH-related peptide (PTHrP), calcilytics, beta-adrenergic receptors, enhancement of Wnt signaling (mainly via sclerostin and Dickkopf-1 neutralization), regulation of low-density lipoprotein receptor-related protein (LPR) 5/osteoblast axis, activin, IGF-1, and bone morphogenic proteins (BMPs) are reviewed for their basic rationale and evidence of bone anabolic potential. Sclerostin neutralizing antibody, teriparatide transdermal patch, and PTHrP (1-36) are currently at an advanced stage of research. Safety and tissue specificity are the prerequisites in the development of a novel treatment, especially when addressing a chronic condition such as osteoporosis. More... »

PAGES

174-195

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.14310/horm.2002.1308

    DOI

    http://dx.doi.org/10.14310/horm.2002.1308

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1067262327

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22001129


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