Assessment of Clinical Meaningfulness of Endpoints in the Generation Program by the Insights to Model Alzheimer’s Progression in Real Life ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Ana Graf, V. Risson, A. Gustavsson, V. Bezlyak, A. Caputo, P. N. Tariot, J. B. Langbaum, C. Lopez Lopez, V. Viglietta

ABSTRACT

We are launching the Insights to Model Alzheimer's Progression in Real Life study in parallel with the Alzheimer Prevention Initiative Generation Program. This is a 5-year, multinational, prospective, longitudinal, non-interventional cohort study that will collect data across the spectrum of Alzheimer's disease. The primary objective is to assess the ability of the Alzheimer's Prevention Initiative Cognitive Composite Test Score and Repeatable Battery for the Assessment of Neuropsychological Status to predict clinically meaningful outcomes such as diagnosis of mild cognitive impairment or dementia due to Alzheimer's disease, and change in Clinical Dementia Rating - Global Score. This study is the first large-scale, prospective effort to establish the clinical meaningfulness of cognitive test scores that track longitudinal decline in preclinical Alzheimer's disease. This study is also expected to contribute to our understanding of the relationships among outcomes in different stages of Alzheimer's disease as well as models of individual trajectories during the course of the disease. More... »

PAGES

85-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.14283/jpad.2018.49

DOI

http://dx.doi.org/10.14283/jpad.2018.49

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110969578

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30756114


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