HbA1c is Associated with Frailty in a Group of Aboriginal Australians View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-29

AUTHORS

Z. Hyde, K. Smith, L. Flicker, D. Atkinson, S. Fenner, L. Skeaf, R. Malay, Dina Lo Giudice

ABSTRACT

In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty. More... »

PAGES

17-20

References to SciGraph publications

  • 2008-09-30. A standard procedure for creating a frailty index in BMC GERIATRICS
  • 2005-05. Frailty and Hormones in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 2012-03-13. Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.14283/jfa.2018.41

    DOI

    http://dx.doi.org/10.14283/jfa.2018.41

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110222433

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30734826


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