Tau phosphorylation in Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Alyson L. Peel, Noah Sorscher, Joseph Y. Kim, Veronica Galvan, Sylvia Chen, Dale E. Bredesen

ABSTRACT

The two predominant pathological concomitants of Alzheimer's disease (AD) are senile plaques and neurofibrillary tangles. Although many biochemical studies have addressed the composition and formation of these AD hallmarks, very little is known about the interrelationship between the two. Here we present evidence that the tau phosphorylation characteristic of neurofibrillary tangles may be mediated by a physical association of MKK6 (mitogen-associated protein kinase kinase 6) with tau and subsequent phosphorylation of tau by the MKK6 substrate, p38 MAPK; and that APP (beta-amyloid precursor protein) may be co-immunoprecipitated both with MKK6 and its upstream MAPKKK, ASK1. Taken together with recent data demonstrating APP dimerization by beta-amyloid peptide (Abeta) (Lu et al., 2003), and the possible activation of ASK1 via APP dimerization (Hashimoto et al., 2003), these results suggest a model of AD in which Abeta peptide dimerizes APP directly, leading to the activation of ASK1, MKK6, and p38, with subsequent phosphorylation of tau at sites characteristic of AD. More... »

PAGES

205-218

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/nmm:5:3:205

DOI

http://dx.doi.org/10.1385/nmm:5:3:205

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021091657

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15626821


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alzheimer Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amyloid beta-Protein Precursor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hippocampus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 6", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase Kinase 5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Signaling System", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurofibrillary Tangles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "p38 Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "tau Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Buck Institute for Research on Aging", 
          "id": "https://www.grid.ac/institutes/grid.272799.0", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peel", 
        "givenName": "Alyson L.", 
        "id": "sg:person.01072622552.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072622552.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Buck Institute for Research on Aging", 
          "id": "https://www.grid.ac/institutes/grid.272799.0", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sorscher", 
        "givenName": "Noah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Buck Institute for Research on Aging", 
          "id": "https://www.grid.ac/institutes/grid.272799.0", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Joseph Y.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Buck Institute for Research on Aging", 
          "id": "https://www.grid.ac/institutes/grid.272799.0", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galvan", 
        "givenName": "Veronica", 
        "id": "sg:person.0741017610.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741017610.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Buck Institute for Research on Aging", 
          "id": "https://www.grid.ac/institutes/grid.272799.0", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Sylvia", 
        "id": "sg:person.07673052477.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673052477.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA", 
            "Department of Neurology, University of California, 94143, San Francisco, CA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bredesen", 
        "givenName": "Dale E.", 
        "id": "sg:person.0642520111.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642520111.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0166-2236(98)01337-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008220882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s007020100016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009673491", 
          "https://doi.org/10.1007/s007020100016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010462789", 
          "https://doi.org/10.1038/sj.onc.1203129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010462789", 
          "https://doi.org/10.1038/sj.onc.1203129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00102.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011194519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000106736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014289093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnen/59.10.880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015069089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1999.0722053.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015129000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.103.051383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015386028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000213229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015693519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108372200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015913781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-9961(03)00086-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022117201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0969-9961(03)00086-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022117201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000067426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026124956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026606413", 
          "https://doi.org/10.1038/74656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/74656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026606413", 
          "https://doi.org/10.1038/74656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00597.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029949823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(97)00483-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031289206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1058189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032878850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.0119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035700109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000063311.58879.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036236739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000063311.58879.01", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036236739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)90940-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040294534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(93)90940-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040294534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1997.69010191.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042031823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(03)00434-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044948714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.neuro.24.1.1121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045688590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0272510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047854450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi0272510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047854450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.10761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048562793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0197-4580(02)00029-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049998478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108357200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050643422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2003.01820.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052334705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5296.90", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.52.6.1158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064377351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.21-17-06597.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074868492"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-06", 
    "datePublishedReg": "2004-06-01", 
    "description": "The two predominant pathological concomitants of Alzheimer's disease (AD) are senile plaques and neurofibrillary tangles. Although many biochemical studies have addressed the composition and formation of these AD hallmarks, very little is known about the interrelationship between the two. Here we present evidence that the tau phosphorylation characteristic of neurofibrillary tangles may be mediated by a physical association of MKK6 (mitogen-associated protein kinase kinase 6) with tau and subsequent phosphorylation of tau by the MKK6 substrate, p38 MAPK; and that APP (beta-amyloid precursor protein) may be co-immunoprecipitated both with MKK6 and its upstream MAPKKK, ASK1. Taken together with recent data demonstrating APP dimerization by beta-amyloid peptide (Abeta) (Lu et al., 2003), and the possible activation of ASK1 via APP dimerization (Hashimoto et al., 2003), these results suggest a model of AD in which Abeta peptide dimerizes APP directly, leading to the activation of ASK1, MKK6, and p38, with subsequent phosphorylation of tau at sites characteristic of AD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1385/nmm:5:3:205", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2557868", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1030361", 
        "issn": [
          "1535-1084", 
          "1559-1174"
        ], 
        "name": "NeuroMolecular Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Tau phosphorylation in Alzheimer\u2019s disease", 
    "pagination": "205-218", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "647dda8c49883dd41b2759bfced1b6c9b41932d7cbc8e0472d63d14d42bf6521"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15626821"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101135365"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1385/nmm:5:3:205"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021091657"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1385/nmm:5:3:205", 
      "https://app.dimensions.ai/details/publication/pub.1021091657"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000499.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1385/NMM:5:3:205"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1385/nmm:5:3:205'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1385/nmm:5:3:205'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1385/nmm:5:3:205'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1385/nmm:5:3:205'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      74 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1385/nmm:5:3:205 schema:about N1f8719150a014f4aaa7a60d27c138d4e
2 N30bea7797d834b8f9861946123f3f7ce
3 N32fedec1a5f748f3a57bb9db0b44ceea
4 N35ff33dba27b4901bbc48d9d761ddb38
5 N6044c141a0f340b8b22c1143b0deda0f
6 N7a99355be30b48bc835944392139bb44
7 N8f5c0584f72d4de3815eb7d979dc055e
8 N99bd937d2e64492f80eaa99e4575fc3a
9 N9b77839d3d514057885ea75e4c8b3cbe
10 N9c394d8632d44b448cd9ec16a9edc630
11 N9f859831d2464e688d1ff55b6512c3ce
12 Na1f694c411ca48dbbfc49599b1ceeb68
13 Nabe40d93975940638f520efb0a822558
14 Nda73d9b7d67048fc8ac55dd5e896cf7d
15 Nef00cf9996f54f569b76135c1d81ef1a
16 anzsrc-for:11
17 anzsrc-for:1109
18 schema:author Nac6b4fa3d6944d9792d0e5cf929f3bf7
19 schema:citation sg:pub.10.1007/s007020100016
20 sg:pub.10.1038/74656
21 sg:pub.10.1038/sj.onc.1203129
22 https://doi.org/10.1002/ana.10761
23 https://doi.org/10.1006/bbrc.1998.0119
24 https://doi.org/10.1016/0006-8993(93)90940-o
25 https://doi.org/10.1016/s0014-5793(97)00483-3
26 https://doi.org/10.1016/s0166-2236(98)01337-x
27 https://doi.org/10.1016/s0197-4580(02)00029-5
28 https://doi.org/10.1016/s0896-6273(03)00434-3
29 https://doi.org/10.1016/s0969-9961(03)00086-x
30 https://doi.org/10.1021/bi0272510
31 https://doi.org/10.1046/j.1471-4159.1997.69010191.x
32 https://doi.org/10.1046/j.1471-4159.1999.0722053.x
33 https://doi.org/10.1046/j.1471-4159.2001.00102.x
34 https://doi.org/10.1046/j.1471-4159.2001.00597.x
35 https://doi.org/10.1046/j.1471-4159.2003.01820.x
36 https://doi.org/10.1074/jbc.m108357200
37 https://doi.org/10.1074/jbc.m108372200
38 https://doi.org/10.1093/jnen/59.10.880
39 https://doi.org/10.1124/jpet.103.051383
40 https://doi.org/10.1126/science.1058189
41 https://doi.org/10.1126/science.275.5296.90
42 https://doi.org/10.1146/annurev.neuro.24.1.1121
43 https://doi.org/10.1159/000067426
44 https://doi.org/10.1159/000106736
45 https://doi.org/10.1159/000213229
46 https://doi.org/10.1212/01.wnl.0000063311.58879.01
47 https://doi.org/10.1212/wnl.52.6.1158
48 https://doi.org/10.1523/jneurosci.21-17-06597.2001
49 schema:datePublished 2004-06
50 schema:datePublishedReg 2004-06-01
51 schema:description The two predominant pathological concomitants of Alzheimer's disease (AD) are senile plaques and neurofibrillary tangles. Although many biochemical studies have addressed the composition and formation of these AD hallmarks, very little is known about the interrelationship between the two. Here we present evidence that the tau phosphorylation characteristic of neurofibrillary tangles may be mediated by a physical association of MKK6 (mitogen-associated protein kinase kinase 6) with tau and subsequent phosphorylation of tau by the MKK6 substrate, p38 MAPK; and that APP (beta-amyloid precursor protein) may be co-immunoprecipitated both with MKK6 and its upstream MAPKKK, ASK1. Taken together with recent data demonstrating APP dimerization by beta-amyloid peptide (Abeta) (Lu et al., 2003), and the possible activation of ASK1 via APP dimerization (Hashimoto et al., 2003), these results suggest a model of AD in which Abeta peptide dimerizes APP directly, leading to the activation of ASK1, MKK6, and p38, with subsequent phosphorylation of tau at sites characteristic of AD.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree false
55 schema:isPartOf N0d1622a131f44f7582333529485ecb98
56 Ndc1eaa3bae414fc6b353fdf505a54bb5
57 sg:journal.1030361
58 schema:name Tau phosphorylation in Alzheimer’s disease
59 schema:pagination 205-218
60 schema:productId N2f7c5442940d420db3205228df9f1bb4
61 N81cd8e5ed9bb4640b7b312b83ae3078e
62 Nd26b8e8399da42d98e9e106a05b3f5c8
63 Nd4c1d75f3e1646eb9c1b2e205f23fb43
64 Nfb41c23d1c48452fbda58fd8a6dfe78f
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021091657
66 https://doi.org/10.1385/nmm:5:3:205
67 schema:sdDatePublished 2019-04-10T18:17
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nd318da06e4de4bd9984ab8475e136118
70 schema:url http://link.springer.com/10.1385/NMM:5:3:205
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N0d1622a131f44f7582333529485ecb98 schema:volumeNumber 5
75 rdf:type schema:PublicationVolume
76 N1f8719150a014f4aaa7a60d27c138d4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Severity of Illness Index
78 rdf:type schema:DefinedTerm
79 N2f7c5442940d420db3205228df9f1bb4 schema:name doi
80 schema:value 10.1385/nmm:5:3:205
81 rdf:type schema:PropertyValue
82 N30bea7797d834b8f9861946123f3f7ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name MAP Kinase Signaling System
84 rdf:type schema:DefinedTerm
85 N32a5acea55b14f048149fa8a48179f01 schema:affiliation https://www.grid.ac/institutes/grid.272799.0
86 schema:familyName Kim
87 schema:givenName Joseph Y.
88 rdf:type schema:Person
89 N32fedec1a5f748f3a57bb9db0b44ceea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aged
91 rdf:type schema:DefinedTerm
92 N35ff33dba27b4901bbc48d9d761ddb38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name MAP Kinase Kinase Kinase 5
94 rdf:type schema:DefinedTerm
95 N4bfd47cd664a42d7aceb63ff0870e7ba rdf:first sg:person.0741017610.34
96 rdf:rest Ne5cbd27bd4ba43048cc598d43ddee51e
97 N6044c141a0f340b8b22c1143b0deda0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Neurofibrillary Tangles
99 rdf:type schema:DefinedTerm
100 N70920d30c32244ef887aef1b0cb9bf0b schema:affiliation https://www.grid.ac/institutes/grid.272799.0
101 schema:familyName Sorscher
102 schema:givenName Noah
103 rdf:type schema:Person
104 N7a99355be30b48bc835944392139bb44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Middle Aged
106 rdf:type schema:DefinedTerm
107 N81cd8e5ed9bb4640b7b312b83ae3078e schema:name readcube_id
108 schema:value 647dda8c49883dd41b2759bfced1b6c9b41932d7cbc8e0472d63d14d42bf6521
109 rdf:type schema:PropertyValue
110 N8f5c0584f72d4de3815eb7d979dc055e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Alzheimer Disease
112 rdf:type schema:DefinedTerm
113 N99bd937d2e64492f80eaa99e4575fc3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name MAP Kinase Kinase 6
115 rdf:type schema:DefinedTerm
116 N9b77839d3d514057885ea75e4c8b3cbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name tau Proteins
118 rdf:type schema:DefinedTerm
119 N9c394d8632d44b448cd9ec16a9edc630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Phosphorylation
121 rdf:type schema:DefinedTerm
122 N9f859831d2464e688d1ff55b6512c3ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Cell Line
124 rdf:type schema:DefinedTerm
125 Na1f694c411ca48dbbfc49599b1ceeb68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Amyloid beta-Protein Precursor
127 rdf:type schema:DefinedTerm
128 Na7691ad4ac8c4b088fa1c39c7d179c83 rdf:first N70920d30c32244ef887aef1b0cb9bf0b
129 rdf:rest Nbf061dde94e342d187c3782d096bac01
130 Nabe40d93975940638f520efb0a822558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name p38 Mitogen-Activated Protein Kinases
132 rdf:type schema:DefinedTerm
133 Nac6b4fa3d6944d9792d0e5cf929f3bf7 rdf:first sg:person.01072622552.12
134 rdf:rest Na7691ad4ac8c4b088fa1c39c7d179c83
135 Nbf061dde94e342d187c3782d096bac01 rdf:first N32a5acea55b14f048149fa8a48179f01
136 rdf:rest N4bfd47cd664a42d7aceb63ff0870e7ba
137 Nd26b8e8399da42d98e9e106a05b3f5c8 schema:name dimensions_id
138 schema:value pub.1021091657
139 rdf:type schema:PropertyValue
140 Nd318da06e4de4bd9984ab8475e136118 schema:name Springer Nature - SN SciGraph project
141 rdf:type schema:Organization
142 Nd4c1d75f3e1646eb9c1b2e205f23fb43 schema:name pubmed_id
143 schema:value 15626821
144 rdf:type schema:PropertyValue
145 Nda73d9b7d67048fc8ac55dd5e896cf7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 Ndc1eaa3bae414fc6b353fdf505a54bb5 schema:issueNumber 3
149 rdf:type schema:PublicationIssue
150 Ndf7dc85054b945ceb6d02e9f489395a4 rdf:first sg:person.0642520111.96
151 rdf:rest rdf:nil
152 Ne5cbd27bd4ba43048cc598d43ddee51e rdf:first sg:person.07673052477.41
153 rdf:rest Ndf7dc85054b945ceb6d02e9f489395a4
154 Nef00cf9996f54f569b76135c1d81ef1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Hippocampus
156 rdf:type schema:DefinedTerm
157 Nfb41c23d1c48452fbda58fd8a6dfe78f schema:name nlm_unique_id
158 schema:value 101135365
159 rdf:type schema:PropertyValue
160 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
161 schema:name Medical and Health Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
164 schema:name Neurosciences
165 rdf:type schema:DefinedTerm
166 sg:grant.2557868 http://pending.schema.org/fundedItem sg:pub.10.1385/nmm:5:3:205
167 rdf:type schema:MonetaryGrant
168 sg:journal.1030361 schema:issn 1535-1084
169 1559-1174
170 schema:name NeuroMolecular Medicine
171 rdf:type schema:Periodical
172 sg:person.01072622552.12 schema:affiliation https://www.grid.ac/institutes/grid.272799.0
173 schema:familyName Peel
174 schema:givenName Alyson L.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072622552.12
176 rdf:type schema:Person
177 sg:person.0642520111.96 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
178 schema:familyName Bredesen
179 schema:givenName Dale E.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642520111.96
181 rdf:type schema:Person
182 sg:person.0741017610.34 schema:affiliation https://www.grid.ac/institutes/grid.272799.0
183 schema:familyName Galvan
184 schema:givenName Veronica
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741017610.34
186 rdf:type schema:Person
187 sg:person.07673052477.41 schema:affiliation https://www.grid.ac/institutes/grid.272799.0
188 schema:familyName Chen
189 schema:givenName Sylvia
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07673052477.41
191 rdf:type schema:Person
192 sg:pub.10.1007/s007020100016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009673491
193 https://doi.org/10.1007/s007020100016
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/74656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026606413
196 https://doi.org/10.1038/74656
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/sj.onc.1203129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010462789
199 https://doi.org/10.1038/sj.onc.1203129
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/ana.10761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048562793
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1006/bbrc.1998.0119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035700109
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0006-8993(93)90940-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1040294534
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s0014-5793(97)00483-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031289206
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0166-2236(98)01337-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008220882
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0197-4580(02)00029-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049998478
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0896-6273(03)00434-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044948714
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0969-9961(03)00086-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022117201
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1021/bi0272510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047854450
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1471-4159.1997.69010191.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042031823
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1046/j.1471-4159.1999.0722053.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015129000
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1046/j.1471-4159.2001.00102.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011194519
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1046/j.1471-4159.2001.00597.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029949823
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1046/j.1471-4159.2003.01820.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052334705
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1074/jbc.m108357200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050643422
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1074/jbc.m108372200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015913781
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/jnen/59.10.880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015069089
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1124/jpet.103.051383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015386028
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1126/science.1058189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032878850
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/science.275.5296.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555416
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1146/annurev.neuro.24.1.1121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045688590
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1159/000067426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026124956
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1159/000106736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014289093
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1159/000213229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015693519
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1212/01.wnl.0000063311.58879.01 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036236739
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1212/wnl.52.6.1158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064377351
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1523/jneurosci.21-17-06597.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074868492
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
256 schema:name Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA
257 Department of Neurology, University of California, 94143, San Francisco, CA
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.272799.0 schema:alternateName Buck Institute for Research on Aging
260 schema:name Buck Institute for Age Research, 8001 Redwood Boulevard, 94945, Novato, CA
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...