Proteomic approach to studying parkinson’s disease View Full Text


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Article Info

DATE

2004-06

AUTHORS

Jing Zhang, David R. Goodlett

ABSTRACT

Parkinson’s disease is a common age-related neurodegenerative disease characterized pathologically by a loss of dopaminergic neurons in the substantia nigra with resultant depletion of striatal dopamine and presence of Lewy bodies in the remaining neurons. The Lewy body contains numerous functional and structural proteins, including α-synuclein and ubiquitin; aggregation of α-synuclein is thought to be important in Lewy body formation as well as neurodegeneration, although the detailed mechanisms remain to be defined. Increasing evidence has suggested that mitochondrial dysfunction, increased oxidative stress, and dysfunction of the ubiquitin-proteasome system may be involved in α-synuclein aggregation, Lewy body formation, and neurodegeneration. However, how these processes are related to each other is not fully understood, given that there are Parkinsonian animal models as well as human diseases with significant nigral neurodegeneration regardless of whether Lewy bodies form or not. This review summarizes the current related research fields and proposes a proteomic approach to investigate the mechanisms that may dictate α-synuclein aggregation, Lewy body formation, and neurodegeneration. More... »

PAGES

271-288

References to SciGraph publications

  • 1999-07. Direct analysis of protein complexes using mass spectrometry in NATURE BIOTECHNOLOGY
  • 2000-12. Chronic systemic pesticide exposure reproduces features of Parkinson's disease in NATURE NEUROSCIENCE
  • 2001-04. Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome in NATURE BIOTECHNOLOGY
  • 2002-09. Proteomics without polyacrylamide: qualitative and quantitative uses of tandem mass spectrometry in proteome analysis in FUNCTIONAL & INTEGRATIVE GENOMICS
  • 2000-07. Is there a cause-and-effect relationship between α-synuclein fibrillization and Parkinson’s disease? in NATURE CELL BIOLOGY
  • 1998-10. The ubiquitin pathway in Parkinson's disease in NATURE
  • 1992-02. In vivo trapping of hydroxyl free radicals in the striatum utilizing intracranial microdialysis perfusion of salicylate: effects of MPTP, MPDP+, and MPP+ in JOURNAL OF NEURAL TRANSMISSION
  • 2000-11. Opening doors into the proteasome in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2000-10-17. PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone in NATURE CELL BIOLOGY
  • 1998-03. Chaperoning brain diseases in NATURE
  • 2003-09. The role of α-synuclein in Parkinson's disease: insights from animal models in NATURE REVIEWS NEUROSCIENCE
  • 2001-09. Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 1996-08. Animal models of Parkinson's disease: An empirical comparison with the phenomenology of the disease in man in JOURNAL OF NEURAL TRANSMISSION
  • 1999-10. Quantitative analysis of complex protein mixtures using isotope-coded affinity tags in NATURE BIOTECHNOLOGY
  • 2000-03. A Drosophila model of Parkinson's disease in NATURE
  • 2001-12. α-synuclein and cytosolic dopamine: Stabilizing a bad situation in NATURE MEDICINE
  • 2002. Recent developments in the pathology of Parkinson’s disease in AGEING AND DEMENTIA CURRENT AND FUTURE CONCEPTS
  • 2002-06. Mutant and wild-type α-synuclein interact with mitochondrial cytochrome C oxidase in JOURNAL OF MOLECULAR NEUROSCIENCE
  • 2002-07-01. Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype in NATURE BIOTECHNOLOGY
  • 2002-11. Pharmacological prevention of Parkinson disease in Drosophila in NATURE MEDICINE
  • 2002-04. Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases in NATURE
  • 1972-10. In vivo generation of hydrogen peroxide from 6-hydroxydopamine in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2002-06-25. Identification of novel candidates for replicative senescence by functional proteomics in ONCOGENE
  • 1998-02. AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease in NATURE GENETICS
  • 2000-02. Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition in CELL DEATH & DIFFERENTIATION
  • 2001-12. 6-Hydroxydopamine Increases Ubiquitin-Conjugates and Protein Degradation: Implications for the Pathogenesis of Parkinson's Disease in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 1998-09. Autosomal dominant Parkinson’s disease in JOURNAL OF NEUROLOGY
  • 2001-08. Failure of the ubiquitin–proteasome system in Parkinson's disease in NATURE REVIEWS NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1385/mn:29:3:271

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    http://dx.doi.org/10.1385/mn:29:3:271

    DIMENSIONS

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    https://www.ncbi.nlm.nih.gov/pubmed/15181239


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