Protein-protein interactions in signaling cascades View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Bruce J. Mayer

ABSTRACT

The process of signal transduction is dependent on specific protein-protein interactions. In many cases these interactions are mediated by modular protein domains that confer specific binding activity to the proteins in which they are found. Rapid progress has been made in the biochemical characterization of binding interactions, the identification of binding partners, and determination of the three-dimensional structures of binding modules and their ligands. The resulting information establishes the logical framework for our current understanding of the signal transduction machinery. In this overview a variety of protein interaction modules are discussed, and issues relating to binding specificity and the significance of a particular interaction are considered. More... »

PAGES

201-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/mb:13:3:201

DOI

http://dx.doi.org/10.1385/mb:13:3:201

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030670797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10934533


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Children\u2019s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwod Avenue, 02116, Boston, MA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Howard Hughes Medical Institute, Children\u2019s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwod Avenue, 02116, Boston, MA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Bruce J.", 
        "id": "sg:person.01244537451.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/363309b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017429166", 
          "https://doi.org/10.1038/363309b0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363015a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023945033", 
          "https://doi.org/10.1038/363015a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0995-715", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038351031", 
          "https://doi.org/10.1038/nsb0995-715"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344678a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040509769", 
          "https://doi.org/10.1038/344678a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/379369a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041590546", 
          "https://doi.org/10.1038/379369a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034992548", 
          "https://doi.org/10.1038/40805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382646a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006863958", 
          "https://doi.org/10.1038/382646a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/378584a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029778580", 
          "https://doi.org/10.1038/378584a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373573a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008518821", 
          "https://doi.org/10.1038/373573a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/379311a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048752425", 
          "https://doi.org/10.1038/379311a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-80481-6_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026270034", 
          "https://doi.org/10.1007/978-3-642-80481-6_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371168a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022090865", 
          "https://doi.org/10.1038/371168a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371297a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001747261", 
          "https://doi.org/10.1038/371297a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-80481-6_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012897468", 
          "https://doi.org/10.1007/978-3-642-80481-6_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-80481-6_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013483217", 
          "https://doi.org/10.1007/978-3-642-80481-6_3"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1999-11", 
    "datePublishedReg": "1999-11-01", 
    "description": "The process of signal transduction is dependent on specific protein-protein interactions. In many cases these interactions are mediated by modular protein domains that confer specific binding activity to the proteins in which they are found. Rapid progress has been made in the biochemical characterization of binding interactions, the identification of binding partners, and determination of the three-dimensional structures of binding modules and their ligands. The resulting information establishes the logical framework for our current understanding of the signal transduction machinery. In this overview a variety of protein interaction modules are discussed, and issues relating to binding specificity and the significance of a particular interaction are considered.", 
    "genre": "article", 
    "id": "sg:pub.10.1385/mb:13:3:201", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106201", 
        "issn": [
          "1073-6085", 
          "1559-0305"
        ], 
        "name": "Molecular Biotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "protein-protein interactions", 
      "specific protein-protein interactions", 
      "protein interaction modules", 
      "modular protein domains", 
      "signal transduction machinery", 
      "transduction machinery", 
      "protein domains", 
      "three-dimensional structure", 
      "signal transduction", 
      "biochemical characterization", 
      "interaction module", 
      "current understanding", 
      "transduction", 
      "rapid progress", 
      "machinery", 
      "particular interaction", 
      "protein", 
      "interaction", 
      "cascade", 
      "domain", 
      "identification", 
      "specificity", 
      "ligands", 
      "characterization", 
      "activity", 
      "partners", 
      "understanding", 
      "variety", 
      "structure", 
      "module", 
      "significance", 
      "progress", 
      "process", 
      "overview", 
      "information", 
      "determination", 
      "logical framework", 
      "framework", 
      "cases", 
      "issues"
    ], 
    "name": "Protein-protein interactions in signaling cascades", 
    "pagination": "201-213", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030670797"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1385/mb:13:3:201"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10934533"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1385/mb:13:3:201", 
      "https://app.dimensions.ai/details/publication/pub.1030670797"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_342.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1385/mb:13:3:201"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1385/mb:13:3:201'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1385/mb:13:3:201'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1385/mb:13:3:201'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1385/mb:13:3:201'


 

This table displays all metadata directly associated to this object as RDF triples.

185 TRIPLES      21 PREDICATES      87 URIs      64 LITERALS      13 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1385/mb:13:3:201 schema:about N0a9aea33cb1e4fc8afeba98165728a72
2 N1e62ce9158a9471893b6be92691e8c9f
3 N1e97331f24664fc6bf26fc9ebb2cda7c
4 N6e3555d78c1b4775be97236e096a419a
5 Nb79c123c042b4b11836c7c16836cb839
6 Nbc69645da6804612b014d2ad3c34ad75
7 anzsrc-for:06
8 anzsrc-for:0601
9 schema:author Nc0a0a0e7cbaf4dc6a28c88ffbc818b6e
10 schema:citation sg:pub.10.1007/978-3-642-80481-6_3
11 sg:pub.10.1007/978-3-642-80481-6_5
12 sg:pub.10.1007/978-3-642-80481-6_9
13 sg:pub.10.1038/344678a0
14 sg:pub.10.1038/363015a0
15 sg:pub.10.1038/363309b0
16 sg:pub.10.1038/371168a0
17 sg:pub.10.1038/371297a0
18 sg:pub.10.1038/373573a0
19 sg:pub.10.1038/378584a0
20 sg:pub.10.1038/379311a0
21 sg:pub.10.1038/379369a0
22 sg:pub.10.1038/382646a0
23 sg:pub.10.1038/40805
24 sg:pub.10.1038/nsb0995-715
25 schema:datePublished 1999-11
26 schema:datePublishedReg 1999-11-01
27 schema:description The process of signal transduction is dependent on specific protein-protein interactions. In many cases these interactions are mediated by modular protein domains that confer specific binding activity to the proteins in which they are found. Rapid progress has been made in the biochemical characterization of binding interactions, the identification of binding partners, and determination of the three-dimensional structures of binding modules and their ligands. The resulting information establishes the logical framework for our current understanding of the signal transduction machinery. In this overview a variety of protein interaction modules are discussed, and issues relating to binding specificity and the significance of a particular interaction are considered.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N4b9fdd460be0483e8213231c7fb00c66
31 N678758d6149c45f996b7b31e7004287d
32 sg:journal.1106201
33 schema:keywords activity
34 biochemical characterization
35 cascade
36 cases
37 characterization
38 current understanding
39 determination
40 domain
41 framework
42 identification
43 information
44 interaction
45 interaction module
46 issues
47 ligands
48 logical framework
49 machinery
50 modular protein domains
51 module
52 overview
53 particular interaction
54 partners
55 process
56 progress
57 protein
58 protein domains
59 protein interaction modules
60 protein-protein interactions
61 rapid progress
62 signal transduction
63 signal transduction machinery
64 significance
65 specific protein-protein interactions
66 specificity
67 structure
68 three-dimensional structure
69 transduction
70 transduction machinery
71 understanding
72 variety
73 schema:name Protein-protein interactions in signaling cascades
74 schema:pagination 201-213
75 schema:productId N5316c170383c4b9cb4080324e070caa5
76 N7f218289574c44de916cd70e8ea94c60
77 Nf849174c4362415f98cc5d4e62213b44
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030670797
79 https://doi.org/10.1385/mb:13:3:201
80 schema:sdDatePublished 2022-09-02T15:49
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N946b470ac4724a01a919f8dff10d32c1
83 schema:url https://doi.org/10.1385/mb:13:3:201
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0a9aea33cb1e4fc8afeba98165728a72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Humans
89 rdf:type schema:DefinedTerm
90 N1e62ce9158a9471893b6be92691e8c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Animals
92 rdf:type schema:DefinedTerm
93 N1e97331f24664fc6bf26fc9ebb2cda7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Protein Binding
95 rdf:type schema:DefinedTerm
96 N4b9fdd460be0483e8213231c7fb00c66 schema:issueNumber 3
97 rdf:type schema:PublicationIssue
98 N5316c170383c4b9cb4080324e070caa5 schema:name doi
99 schema:value 10.1385/mb:13:3:201
100 rdf:type schema:PropertyValue
101 N678758d6149c45f996b7b31e7004287d schema:volumeNumber 13
102 rdf:type schema:PublicationVolume
103 N6e3555d78c1b4775be97236e096a419a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Signal Transduction
105 rdf:type schema:DefinedTerm
106 N7f218289574c44de916cd70e8ea94c60 schema:name pubmed_id
107 schema:value 10934533
108 rdf:type schema:PropertyValue
109 N946b470ac4724a01a919f8dff10d32c1 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 Nb79c123c042b4b11836c7c16836cb839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Proteins
113 rdf:type schema:DefinedTerm
114 Nbc69645da6804612b014d2ad3c34ad75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Ligands
116 rdf:type schema:DefinedTerm
117 Nc0a0a0e7cbaf4dc6a28c88ffbc818b6e rdf:first sg:person.01244537451.59
118 rdf:rest rdf:nil
119 Nf849174c4362415f98cc5d4e62213b44 schema:name dimensions_id
120 schema:value pub.1030670797
121 rdf:type schema:PropertyValue
122 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
123 schema:name Biological Sciences
124 rdf:type schema:DefinedTerm
125 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
126 schema:name Biochemistry and Cell Biology
127 rdf:type schema:DefinedTerm
128 sg:journal.1106201 schema:issn 1073-6085
129 1559-0305
130 schema:name Molecular Biotechnology
131 schema:publisher Springer Nature
132 rdf:type schema:Periodical
133 sg:person.01244537451.59 schema:affiliation grid-institutes:grid.38142.3c
134 schema:familyName Mayer
135 schema:givenName Bruce J.
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59
137 rdf:type schema:Person
138 sg:pub.10.1007/978-3-642-80481-6_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013483217
139 https://doi.org/10.1007/978-3-642-80481-6_3
140 rdf:type schema:CreativeWork
141 sg:pub.10.1007/978-3-642-80481-6_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012897468
142 https://doi.org/10.1007/978-3-642-80481-6_5
143 rdf:type schema:CreativeWork
144 sg:pub.10.1007/978-3-642-80481-6_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026270034
145 https://doi.org/10.1007/978-3-642-80481-6_9
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/344678a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040509769
148 https://doi.org/10.1038/344678a0
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/363015a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023945033
151 https://doi.org/10.1038/363015a0
152 rdf:type schema:CreativeWork
153 sg:pub.10.1038/363309b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017429166
154 https://doi.org/10.1038/363309b0
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/371168a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022090865
157 https://doi.org/10.1038/371168a0
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/371297a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001747261
160 https://doi.org/10.1038/371297a0
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/373573a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008518821
163 https://doi.org/10.1038/373573a0
164 rdf:type schema:CreativeWork
165 sg:pub.10.1038/378584a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029778580
166 https://doi.org/10.1038/378584a0
167 rdf:type schema:CreativeWork
168 sg:pub.10.1038/379311a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048752425
169 https://doi.org/10.1038/379311a0
170 rdf:type schema:CreativeWork
171 sg:pub.10.1038/379369a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041590546
172 https://doi.org/10.1038/379369a0
173 rdf:type schema:CreativeWork
174 sg:pub.10.1038/382646a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006863958
175 https://doi.org/10.1038/382646a0
176 rdf:type schema:CreativeWork
177 sg:pub.10.1038/40805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034992548
178 https://doi.org/10.1038/40805
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/nsb0995-715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038351031
181 https://doi.org/10.1038/nsb0995-715
182 rdf:type schema:CreativeWork
183 grid-institutes:grid.38142.3c schema:alternateName Howard Hughes Medical Institute, Children’s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwod Avenue, 02116, Boston, MA
184 schema:name Howard Hughes Medical Institute, Children’s Hospital and Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwod Avenue, 02116, Boston, MA
185 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...