Protein-protein interactions in signaling cascades View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-11

AUTHORS

Bruce J. Mayer

ABSTRACT

The process of signal transduction is dependent on specific protein-protein interactions. In many cases these interactions are mediated by modular protein domains that confer specific binding activity to the proteins in which they are found. Rapid progress has been made in the biochemical characterization of binding interactions, the identification of binding partners, and determination of the three-dimensional structures of binding modules and their ligands. The resulting information establishes the logical framework for our current understanding of the signal transduction machinery. In this overview a variety of protein interaction modules are discussed, and issues relating to binding specificity and the significance of a particular interaction are considered. More... »

PAGES

201-213

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/mb:13:3:201

DOI

http://dx.doi.org/10.1385/mb:13:3:201

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030670797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10934533


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