Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-Activated NK cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-09

AUTHORS

Tatiana Raskovalova, Anna Lokshin, Xiaojun Huang, Edwin K. Jackson, Elieser Gorelik

ABSTRACT

Adenosine suppresses the production of various cytokines/ chemokines and inhibits the cytotoxic activity of murine and human NK cells activated with IL-2 or Ly49D, NKp46-receptor crosslinking, respectively. These effects are mediated by the type A2A adenosine receptor via stimulation of adenylyl cyclase, increased production of cAMP, and activation of PKA. PKA I, but not PKA II, participates in the inhibitory effects of adenosine. Blocking regulatory, but not catalytic, subunits of PKA I abrogates the inhibitory effects of adenosine. These findings suggest that tumor-produced adenosine inhibits the activity of NK and other effector cells and thereby protects tumors from immune-mediated destruction. More... »

PAGES

91-99

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/ir:36:1:91

DOI

http://dx.doi.org/10.1385/ir:36:1:91

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012457148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17337770


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