Threat matrix View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04

AUTHORS

Jonathan D. Powell, Maureen R. Horton

ABSTRACT

Whether or not T cell receptor engagement leads to full activation or tolerance is determined by the context in which the antigen is encountered. Antigen presented by activated APCs in the presence of costimulation leads to full T cell activation, while antigen presented by resting APCs leads to tolerance. Pathogen-associated molecular patterns in the form of toll-like receptor ligands play a critical role in activating APCs and promoting T cell activation. In this review we hypothesize that low-molecular-weight species of the extracellular matrix polymer hyaluronan also performs this function by acting as an endogenous danger signal. More... »

PAGES

207-218

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/ir:31:3:207

DOI

http://dx.doi.org/10.1385/ir:31:3:207

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041462788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15888912


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