Human genetics of common mycobacterial infections View Full Text


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Article Info

DATE

2003-10

AUTHORS

Natascha Remus, Alexandre Alcaïs, Laurent Abel

ABSTRACT

There is increasing interest in and understanding of the role of human genetic factors controlling susceptibility/resistance to infectious diseases. This is of particular importance for the two most common mycobacterial infections, tuberculosis and leprosy, because this will allow a genetic dissection of antimycobacterial immunity and should open new fields of preventive and therapeutic measures. In this review we will initially discuss various methods of genetic epidemiology that have been and are being developed to identify human genes controlling infectious diseases, and then illustrate the findings obtained in the numerous studies performed in tuberculosis and leprosy. Although the most convincing results were observed for HLA-DR2 and NRAMP1 (or a closely linked gene) in pulmonary tuberculosis and leprosy subtypes and for a 10p13 locus in paucibacillary leprosy, the molecular basis of their effects remains to be established. More... »

PAGES

109-129

References to SciGraph publications

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  • 2001-04-20. The family based association test method: strategies for studying general genotype–phenotype associations in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2003-02-10. Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population in NATURE GENETICS
  • 1999-06. Prospects for whole-genome linkage disequilibrium mapping of common disease genes in NATURE GENETICS
  • 2003-04-14. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy in NATURE MEDICINE
  • 2001-04. A major susceptibility locus for leprosy in India maps to chromosome 10p13 in NATURE GENETICS
  • 2000-06. Vitamin D Deficiency and Susceptibility to Tuberculosis in CALCIFIED TISSUE INTERNATIONAL
  • 2001-06. Computational analysis of microarray data in NATURE REVIEWS GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1385/ir:28:2:109

    DOI

    http://dx.doi.org/10.1385/ir:28:2:109

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017373167

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14610288


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