Molecular forms of serum pancreatic stone protein in acute pancreatitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-02

AUTHORS

Yasuyuki Nakae, Satoru Naruse, Motoji Kitagawa, Hiroshi Ishiguro, Masanori Kato, Shinobu Hayakawa, Takaharu Kondo, Tetsuo Hayakawa

ABSTRACT

Conclusion: Elevation of serum pancreatic stone protein- (PSP) S1 suggests activation of trypsinogen in the pancreas. This information would prompt the start of intensive treatment and may improve prognosis of acute pancreatitis (AP).Background: PSP exists in two molecular forms, PSP-S2–5 and PSP-S1. PSP-S1 is produced by enzyme cleavage of PSP-S2–5 by trypsin. Total serum PSP rose in AP, but little is known about its molecular forms. In this study, we characterized the molecular forms of serum PSP in AP.Methods: Sera were taken from 8 patients with severe acute pancreatitis (sAP) and from 11 patients with mild acute pancreatitis (mAP). Serum PSP was characterized by high-performance liquid chromatography (HPLC) followed by the specific enzyme immunoassay (EIA).Results: The total serum PSP in sAP was higher than in mAP, but the difference was not significant. The PSP-S1 was detected in serum in all (7/7) patients in sAP and in 72% (8/11) of patients in mAP. Serum level of PSP-S1 was significantly higher in sAP than that in mAP (p<0.05), and the cutoff value to distinguish the two groups was 30 ng/mL. Serum PSP-S1 did not show significant correlation with total PSP, immunoreactive trypsin, or C-reactive protein. More... »

PAGES

17-21

References to SciGraph publications

  • 1993-04. Serum pancreatic stone protein in pancreatic diseases in JOURNAL OF GASTROINTESTINAL CANCER
  • 1986-03. Activation of pancreatic zymogens in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1385/ijgc:25:1:17

    DOI

    http://dx.doi.org/10.1385/ijgc:25:1:17

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005059198

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/10211417


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