Change in expression of basic fibroblast growth factor mRNA in a pituitary tumor clonal cell line View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

Hitomi Fukuro, Chihiro Mogi, Kotaro Yokoyama, Kinji Inoue

ABSTRACT

To study pituitary tumor formation, we used a rat pituitary tumor cell line, MtT/E, which was derived from an estrogen-induced rat prolactinoma. MtT/E cells are known not to produce any pituitary hormone; however, they do produce the Pit-1 protein, which is known to be a common transcription factor in thyrotropes, somatotropes, and mammotropes. Although MtT/E is a clonal cell line, it exhibits two distinct phenotypes, fibroblastic (F-) and epithelial (E-) cells. We obtained subclonal cell lines from MtT/E cells with characters similar to those of F- and E-cells and called them MtT/E-G1 and MtT/E-B3, respectively. To examine tumor formation by these cells, we implanted them into female Fischer rats. One month later, typical pituitary tumors had appeared in MtT/E-B3-implanted rats; however, tumor formation by MtT/E-G1 was delayed. Interestingly, the tumors formed by MtT/E-B3 cells were intensely vascularized. To examine changes in tumor cell morphology, we performed primary culture and found that spindle-shaped cells appeared. These spindle-shaped cells were immunopositive for the Pit-1 protein, which suggests that they originated from MtT/E-B3 cells. Interestingly, reverse transcriptase polymerase chain reaction showed that both tumors and the cells obtained in primary culture expressed basic fibroblast growth factor (bFGF). By contrast, the original MtT/E-B3 cells did not express bFGF. These results suggested that MtT/E-B3 cells show a change in phenotype during tumor formation; that is, epithelial-type cells change into bFGF-expressing fibroblastic cells. These phenomena, especially the appearance of bFGF-expressing cells in tumor tissue, may explain the extensive angiogenesis in the tumors formed by MtT/E-B3 cells. More... »

PAGES

145-149

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/ep:14:2:145

DOI

http://dx.doi.org/10.1385/ep:14:2:145

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050117023

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12858005


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