How obesity develops View Full Text


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Article Info

DATE

2000-10

AUTHORS

David York, Claude Bouchard

ABSTRACT

Molecular and genetic studies of animal models have identified numerous genes that may cause or contribute to the development of obesity. They have also provided significant insight into the peripheral and central pathways that control energy intake and expenditure. Genetic studies of families and populations have generated useful information on genes and mutations associated with or linked to obesity, body fat distribution, and other relevant phenotypes. This information, combined with knowledge of the chromosomal location of genes identified from animal studies, has made it possible to identify specific mutations that contribute to the development of obesity in humans. More... »

PAGES

143-154

References to SciGraph publications

  • 1998-06. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans in NATURE GENETICS
  • 1997-05. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese in NATURE
  • 1994-10. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor in NATURE
  • 1998-12. Mice lacking melanin-concentrating hormone are hypophagic and lean in NATURE
  • 1998-05. Hypothalamic CART is a new anorectic peptide regulated by leptin in NATURE
  • 1993-12. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue in NATURE
  • 1996-02. Abnormal splicing of the leptin receptor in diabetic mice in NATURE
  • 1996-05. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y in NATURE
  • 1997-11. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity in NATURE
  • 1996-07. A receptor subtype involved in neuropeptide-Y-induced food intake in NATURE
  • 1998-03. A leptin missense mutation associated with hypogonadism and morbid obesity in NATURE GENETICS
  • 1998-06. Role of the Y5 neuropeptide Y receptor in feeding and obesity in NATURE MEDICINE
  • 1997-10. Familial risk ratios for extreme obesity: implications for mapping human obesity genes in INTERNATIONAL JOURNAL OF OBESITY
  • 1997-06. Congenital leptin deficiency is associated with severe early-onset obesity in humans in NATURE
  • 1998-11. A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 in NATURE GENETICS
  • 1997-03. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 in NATURE GENETICS
  • 1999-09-01. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin in NATURE MEDICINE
  • 1996-11. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene in NATURE MEDICINE
  • 1997-01. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome in NATURE
  • 1996-05. Leptin receptor missense mutation in the fatty Zucker rat in NATURE GENETICS
  • 1978-03. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice in DIABETOLOGIA
  • 1998-03. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction in NATURE
  • 1996-07. Feeding inhibition by neuropeptide Y in NATURE
  • 1999-03. The mouse mahogany locus encodes a transmembrane form of human attractin in NATURE
  • 1997-07. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene in NATURE GENETICS
  • 1999-03. The mahogany protein is a receptor involved in suppression of obesity in NATURE
  • 1996-08. Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A in NATURE
  • 1997-07. Genetic and Environmental Factors in Relative Body Weight and Human Adiposity in BEHAVIOR GENETICS
  • 1996-03. A role for melanin-concentrating hormone in the central regulation of feeding behaviour in NATURE
  • 1998-10. A frameshift mutation in human MC4R is associated with a dominant form of obesity in NATURE GENETICS
  • 1998-10. A frameshift mutation in MC4R associated with dominantly inherited human obesity in NATURE GENETICS
  • 1994-12. Positional cloning of the mouse obese gene and its human homologue in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1385/endo:13:2:143

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    http://dx.doi.org/10.1385/endo:13:2:143

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11186216


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    52 schema:description Molecular and genetic studies of animal models have identified numerous genes that may cause or contribute to the development of obesity. They have also provided significant insight into the peripheral and central pathways that control energy intake and expenditure. Genetic studies of families and populations have generated useful information on genes and mutations associated with or linked to obesity, body fat distribution, and other relevant phenotypes. This information, combined with knowledge of the chromosomal location of genes identified from animal studies, has made it possible to identify specific mutations that contribute to the development of obesity in humans.
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