Molecular beacons View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Xiaohong Fang, Yanming Mi, Jianwei Jeffery Li, Terry Beck, Sheldon Schuster, Weihong Tan

ABSTRACT

Molecular beacons are a new class of fluorescent probes that can report the presence of specific nucleic acids with high sensitivity and excellent specificity. In addition to their current wide applications in monitoring the progress of polymerase chain reactions, their unique properties make them promising probes for the detection and visualization of target biomolecules in living cells. This article is focused on our recent research in exploring the potential of using molecular beacon for living-cell studies in three important areas: the monitoring of mRNA in living cells, the development of ultrasmall DNA/RNA biosensors, and the novel approach of combining molecular beacon's signal transduction mechanism with aptamer's specificity for real-time protein detection. These applications demonstrate molecular beacon's unique properties in bioanalysis and bioassay development. More... »

PAGES

71-81

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/cbb:37:2:071

DOI

http://dx.doi.org/10.1385/cbb:37:2:071

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046438422

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12482132


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