Development of a Radiolabeled Monoclonal Antibody to Prostate-Specific Membrane Antigen View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005

AUTHORS

Stanley J. Goldsmith , Shankar Vallabhajosula , Matthew I. Milowsky , David M. Nanus , Lale Kostakoglu , Neil H. Bander

ABSTRACT

Despite advances in the diagnosis and therapy of prostate carcinoma, it remains a serious medical problem accounting for a large number of malignancies in men each year. Although earlier detection is now possible, many patients develop advanced metastatic disease even when there is no evidence of spread at the time of initial diagnosis and treatment. These metastatic sites could initially be controlled by hormonal therapy but ultimately become resistant and the disease enters an aggressive stage for which there is currently no satisfactory therapy. In response to this perceived need, monoclonal antibodies have been considered a direct biological modifier of the disease and a vehicle to deliver radioactive metals and other cytotoxic agents to disseminated tumor sites. J591 is a monoclonal antibody that recognizes the internal portion of PSMA, a prostatespecific membrane antigen that is regularly expressed, almost exclusively, on prostate cancer tissue. The antibody has been “humanized” to reduce immune responses to it and labeled with radioactivity. Gamma-ray-emitting labeled forms of this antibody have demonstrate a high degree of binding and β-emitting labeled forms have demostrated antitumor effects in animal models. Several of the radiolabeled forms are undergoing clinical trials in humans. More... »

PAGES

617-625

References to SciGraph publications

Book

TITLE

The Oncogenomics Handbook

ISBN

978-1-58829-425-8

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-893-5:617

DOI

http://dx.doi.org/10.1385/1-59259-893-5:617

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1089648347


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