Docetaxel for Metastatic Cancer and Its Role in Combination Therapies for Advanced Prostate Cancer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2005

AUTHORS

Ellen K. Wasan , Martin Gleave , Karen Fang , Kim Chi , Gwyn Bebb , Lincoln Edwards , Marcel B. Bally

ABSTRACT

Although strides have been made in the diagnosis and treatment of cancer in the past few decades, advanced, metastatic cancer remains extremely difficult to treat. Obviously, a major hurdle in improving survival is the treatment or prevention of metastatic disease, either to eliminate it completely or to contain it like other chronic diseases. To reach the metastatic stage, the cancer cells undergo many and various changes in the usual regulatory mechanisms governing cellular proliferation and apoptosis, resulting in great heterogeneity. Therein lies the challenge in developing appropriate and effective combination therapies for metastatic disease that utilize multiple mechanisms to overcome resistance to cell death. In this chapter, the relatively new cytotoxic taxane docetaxel will be discussed in the context of its current role in treating metastatic cancer and its future role in combination with novel, molecularly targeted chemotherapeutic agents. More... »

PAGES

255-292

Book

TITLE

Bone Metastasis

ISBN

978-1-58829-403-6
978-1-59259-892-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-892-7:255

DOI

http://dx.doi.org/10.1385/1-59259-892-7:255

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044740891


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