Using Nucleases to Stimulate Homologous Recombination View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004-12-29

AUTHORS

Alan S. Waldman , Dana Carroll

ABSTRACT

In essentially all organisms, double-strand breaks in chromosomal DNA stimulate repair by multiple mechanisms, including homologous recombination. It is possible to use site-specific reagents to produce a break or other recombinagenic damage at a unique site, which makes possible detailed analysis of the repair products. In addition, targeted mutagenesis and gene replacement are stimulated in the immediate vicinity of the break site. To utilize meganucleases with long recognition sequences, it is necessary to introduce the corresponding sequence prior to directed cleavage. The same is typically true of triplex-forming oligonucleotides that target polypurine-polypyrimidine tracts. Zinc-finger nucleases have the potential of being targetable to arbitrarily selected sites, owing to the flexibility of zinc finger recognition of DNA. More... »

PAGES

195-208

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-761-0:195

DOI

http://dx.doi.org/10.1385/1-59259-761-0:195

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039769214

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14769963


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1385/1-59259-761-0:195'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1385/1-59259-761-0:195'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1385/1-59259-761-0:195'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1385/1-59259-761-0:195'


 

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