Purification and Identification of Protein Complexes That Control the Cell Cycle View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003-11-14

AUTHORS

Howard B. Lieberman , Matthew A. Burtelow , Vladimir N. Podust , Larry M. Karnitz

ABSTRACT

The human Rad9-Hus1-Rad1 (9-1-1) and Rad17-RFC40-RFC38-RFC37-RFC36 (hRad17-RFC) protein complexes are important components of the mammalian deoxyribonucleic acid (DNA) damage response. Accumulating evidence from biochemical and molecular modeling studies indicate that these two complexes function as a clamp-clamp loader pair (1). The 9-1-1 complex is converted to a less-extractable, DNA-bound form after DNA damage (2). DNA damage-inducible binding of the 9-1-1 complex to chromatin is dependent on hRad17, but independent of ataxia-telangiectasia and Rad3 (ATR) (3). These data support a model in which hRad17-RFC and 9-1-1 are essential components of a DNA damage sensor that functions early in the DNA damage checkpoint pathway. More... »

PAGES

247-254

Book

TITLE

Cell Cycle Checkpoint Control Protocols

ISBN

1-59259-646-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-646-0:247

DOI

http://dx.doi.org/10.1385/1-59259-646-0:247

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044540733


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