Centromeres and Neocentromeres View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2003-11-30

AUTHORS

Gérard Roizés , Christoph Grunau , Jérôme Buard , Albertina De Sario , Jacques Puechberty

ABSTRACT

A functional centromere is formed by a chromosomal domain that very often, but not always, is recognizable by a primary constriction in metaphasic chromosomes. It is associated with a kinetochore through which a link is established with the microtubules, which pull the sister chromatids toward the poles of the two daughter cells during cell division. Centromeres therefore mediate chromosome segregation during mitosis and meiosis, but in ways that are relatively different. For instance, binding of the two sister chromatids is normally destroyed at anaphase in mitosis whereas binding is maintained in meiosis all along the first division until anaphase of the second is reached. The same locus is, however, in charge of the two distinct processes. More... »

PAGES

77-104

Book

TITLE

Mammalian Artificial Chromosomes

ISBN

978-1-58829-096-0
978-1-59259-434-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-434-4:77

DOI

http://dx.doi.org/10.1385/1-59259-434-4:77

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029789201


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