Immunochemical Detection of Nitric Oxide Synthase in Human Tissue View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000

AUTHORS

Lee D. K. Buttery , Julia M. Polak

ABSTRACT

To date three distinct isoforms of nitric oxide synthase (NOS) have been identified. Two isoforms are considered to be expressed constitutively—neu-ronal NOS (nNOS; type I NOS) and endothelial NOS (eNOS; type III NOS). The third isoform is not generally present in normal cells and tissues but is induced in response to infection, inflammation or trauma—inducible NOS (iNOS; type II NOS). In 1990 Bredt and Synder (1) succeeded in developing antibodies to rat brain NOS (nNOS) and used immuncytochemistry subsequently to furnish one of the first anatomical descriptions of the distribution and localization of nNOS. Today numerous antibodies to all three NOS isoforms isolated from various tissues and different animal species are available and the application of immunocytochemistry is commonplace in the investigation of NOS in healthy and diseased tissues including human (2–6) (Fig. 1Fig. 2Fig. 3). More... »

PAGES

145-157

Book

TITLE

Septic Shock Methods and Protocols

ISBN

978-0-89603-730-4
978-1-59259-216-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-216-3:145

DOI

http://dx.doi.org/10.1385/1-59259-216-3:145

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034211802

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21340971


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