In Vitro Studies of Ricin A-Chain-Induced Vascular Leak Syndrome View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-12-22

AUTHORS

Walter A. Hall , Alan L. Lindstrom , Christopher A. Pennell

ABSTRACT

The major dose-limiting toxicity associated with ricin-conjugated immunotoxins (ITs) is vascular leak syndrome (VLS). IT-induced VLS appears to be dose dependent, occurs 2–4 d posttreatment (1–6), and is thought to be a result of the toxin moiety, rather than the targeting moiety, because VLS is associated with ITs containing targeting moieties with different specificities. In addition, whole antibodies and FAb fragments can cause VLS, suggesting that this toxicity is not a result of Fc receptor binding or complement fixation (1– 6. More... »

PAGES

125-135

Book

TITLE

Immunotoxin Methods and Protocols

ISBN

1-59259-114-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-114-0:125

DOI

http://dx.doi.org/10.1385/1-59259-114-0:125

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012181941


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