Detection of Microsatellite Instability View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-09-22

AUTHORS

Anthony A. Killeen , Karin D. Berg , Constance A. Griffin , James R. Eshleman

ABSTRACT

In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER). A recent international consensus conference convened by the National Cancer Institute defined MSI/RER as "a change in length due to either insertion or deletion of repeating units, in a microsatellite within a tumor when compared to normal tissue" (5). Microsatellites are regions of repetitive DNA in which the repeating unit is small, varying in length from 1 to 6 nucleotides, and in which the number of repeating units in a microsatellite can vary from 10-60 (6-7). Because microsatellite lengths generally vary from person to person, they have received widespread use in forensics, gene mapping, parentage testing. More... »

PAGES

59-71

Book

TITLE

Molecular Pathology Protocols

ISBN

1-59259-081-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-081-0:59

DOI

http://dx.doi.org/10.1385/1-59259-081-0:59

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021820977

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21370133


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