Using Surface Electrodes to Monitor the Electric- Pulse-Induced Permeabilization of Porcine Skin View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Stephen A. Gallo , Patricia G. Johnson , Sek Wen Hui

ABSTRACT

The stratum corneum, the outermost layer of the skin, acts as a barrier between the skin and the outside world, preventing evaporation of water from underlying tissues while impeding the diffusion of foreign molecules into the body (1,2). Densely packed layers of flattened, dead, keratinized cells (2,3) are incorporated into a lipid lamellae matrix consisting primarily of ceramides, cholesterol, and fatty acids (2,4), forming an impermeable, hydrophobic partition. The stratum corneum represents the main obstacle to efficient transdermal drug delivery (1,2). If the stratum corneum is disrupted, the barrier to molecular transport is greatly reduced. More... »

PAGES

437-45

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:437

DOI

http://dx.doi.org/10.1385/1-59259-080-2:437

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022650863

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445758


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