Ex Vivo Stromal Cell Electroporation of Factor IX cDNA for Treatment of Hemophilia B View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Armand Keating , Edward Nolan , Robin Filshie , Sukhendu B. Dev

ABSTRACT

Hemophilia B is an X-linked genetic disorder that typically results from chronic circulating deficiency of blood coagulation factor IX (FIX) (1). While the occurrence of hemophilia B is significantly less frequent than hemophilia A (factor VIII, deficiency) it has received special attention as a model for gene therapy. This is because hemophilia B is one of the least complicated genetic diseases from the point of view of demonstrating the proof of principle of a gene therapy protocol. Specifically, hemophilia B is a single gene recessive disorder and a wide range of tissues can be targeted for FIX gene delivery and strict regulation of FIX expression is not required. In addition, the 2.8 kb FIX cDNA is much smaller than the 9 kb FVIII cDNA, and FIX expression in transfected mammalian cells has been less problematic than FVIII expression (2). Since clinical severity of bleeding episodes closely corresponds to a patient's FIX activity, achieving even partial restoration of normal FIX levels in the bloodstream can alleviate internal bleeding. Individuals with FIX levels less than 1% of normal experience severe symptomatic episodes but providing roughly 5% of normal levels (i.e., 250 ng/mL plasma) can significantly reduce the frequency and severity of bleeding episodes and reduce long term complications (3). Treatment of hemophilia B primarily relies on intravenous injections of FIX protein purified from pooled human plasma, or very recently, on newly developed recombinant FIX. Treatment is applied typically only when bleeding episodes have occurred or are expected, for example, in case of a trauma or surgery. Although the risk of viral transmission of HIV and hepatitis viruses has been largely eliminated the absolute safety of any product derived from blood cannot be guaranteed. Furthermore, supplies of factor concentrates are limited and costs (especially if prophylactic treatment is being considered) are high. Thus, the application of gene therapy to hemophilia, whereby long-term correction of factor IX deficiency might be achieved, would be extremely useful. More... »

PAGES

359-68

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:359

DOI

http://dx.doi.org/10.1385/1-59259-080-2:359

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046627000

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445754


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biotechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Jaroszeski", 
        "givenName": "Mark J.", 
        "id": "sg:person.01144305106.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Heller", 
        "givenName": "Richard", 
        "id": "sg:person.01057200577.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gilbert", 
        "givenName": "Richard", 
        "id": "sg:person.0716725263.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keating", 
        "givenName": "Armand", 
        "id": "sg:person.01210555120.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210555120.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genetronics Inc."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nolan", 
        "givenName": "Edward", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Filshie", 
        "givenName": "Robin", 
        "id": "sg:person.0737341331.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737341331.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Genetronics Inc."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dev", 
        "givenName": "Sukhendu B.", 
        "id": "sg:person.0726170272.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726170272.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.94.4.1426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002780220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(90)91210-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003294485"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.3.540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004710089"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004830922", 
          "https://doi.org/10.1038/sj.gt.3300548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004830922", 
          "https://doi.org/10.1038/sj.gt.3300548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-8862-3_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006644940", 
          "https://doi.org/10.1007/978-1-4613-8862-3_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1297-1388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014301385", 
          "https://doi.org/10.1038/nbt1297-1388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/15.3.1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016229210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0293-180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027377728", 
          "https://doi.org/10.1038/ng0293-180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.16.6141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028547680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12319194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030117017", 
          "https://doi.org/10.1111/1523-1747.ep12319194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1523-1747.ep12319194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030117017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.21.11563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032141878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.6.2353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037439633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0797-270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038688300", 
          "https://doi.org/10.1038/ng0797-270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.10.8.4239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042061197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(93)81208-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042582437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.11.5804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046830591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288589", 
          "https://doi.org/10.1038/38410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/38410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288589", 
          "https://doi.org/10.1038/38410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1997.8.2-137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059271985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1998.9.3-353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1998.9.4-591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/4.6.993", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8211118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.1.1.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071505097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077306574", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078637804", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082393787", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.bmb.a072953", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082404554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082605286", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-02-18", 
    "datePublishedReg": "2000-02-18", 
    "description": "Hemophilia B is an X-linked genetic disorder that typically results from chronic circulating deficiency of blood coagulation factor IX (FIX) (1). While the occurrence of hemophilia B is significantly less frequent than hemophilia A (factor VIII, deficiency) it has received special attention as a model for gene therapy. This is because hemophilia B is one of the least complicated genetic diseases from the point of view of demonstrating the proof of principle of a gene therapy protocol. Specifically, hemophilia B is a single gene recessive disorder and a wide range of tissues can be targeted for FIX gene delivery and strict regulation of FIX expression is not required. In addition, the 2.8 kb FIX cDNA is much smaller than the 9 kb FVIII cDNA, and FIX expression in transfected mammalian cells has been less problematic than FVIII expression (2). Since clinical severity of bleeding episodes closely corresponds to a patient's FIX activity, achieving even partial restoration of normal FIX levels in the bloodstream can alleviate internal bleeding. Individuals with FIX levels less than 1% of normal experience severe symptomatic episodes but providing roughly 5% of normal levels (i.e., 250 ng/mL plasma) can significantly reduce the frequency and severity of bleeding episodes and reduce long term complications (3). Treatment of hemophilia B primarily relies on intravenous injections of FIX protein purified from pooled human plasma, or very recently, on newly developed recombinant FIX. Treatment is applied typically only when bleeding episodes have occurred or are expected, for example, in case of a trauma or surgery. Although the risk of viral transmission of HIV and hepatitis viruses has been largely eliminated the absolute safety of any product derived from blood cannot be guaranteed. Furthermore, supplies of factor concentrates are limited and costs (especially if prophylactic treatment is being considered) are high. Thus, the application of gene therapy to hemophilia, whereby long-term correction of factor IX deficiency might be achieved, would be extremely useful.", 
    "genre": "chapter", 
    "id": "sg:pub.10.1385/1-59259-080-2:359", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "1-59259-080-2"
      ], 
      "name": "Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery", 
      "type": "Book"
    }, 
    "name": "Ex Vivo Stromal Cell Electroporation of Factor IX cDNA for Treatment of Hemophilia B", 
    "pagination": "359-68", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1385/1-59259-080-2:359"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "de1cc25e3050560d521d7340d5197a26bf871e56458579f772abc72f1ae14020"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046627000"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21445754"
        ]
      }
    ], 
    "publisher": {
      "location": "New Jersey", 
      "name": "Humana Press", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1385/1-59259-080-2:359", 
      "https://app.dimensions.ai/details/publication/pub.1046627000"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T12:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000272.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1385/1-59259-080-2:359"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:359'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:359'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:359'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:359'


 

This table displays all metadata directly associated to this object as RDF triples.

195 TRIPLES      22 PREDICATES      55 URIs      19 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1385/1-59259-080-2:359 schema:about anzsrc-for:10
2 anzsrc-for:1004
3 schema:author N6e9dee0d4108408a96801894a9f4afcb
4 schema:citation sg:pub.10.1007/978-1-4613-8862-3_11
5 sg:pub.10.1038/38410
6 sg:pub.10.1038/nbt1297-1388
7 sg:pub.10.1038/ng0293-180
8 sg:pub.10.1038/ng0797-270
9 sg:pub.10.1038/sj.gt.3300548
10 sg:pub.10.1111/1523-1747.ep12319194
11 https://app.dimensions.ai/details/publication/pub.1077306574
12 https://app.dimensions.ai/details/publication/pub.1078637804
13 https://app.dimensions.ai/details/publication/pub.1082393787
14 https://app.dimensions.ai/details/publication/pub.1082605286
15 https://doi.org/10.1016/0006-291x(90)91210-j
16 https://doi.org/10.1016/s0006-3495(93)81208-6
17 https://doi.org/10.1073/pnas.87.16.6141
18 https://doi.org/10.1073/pnas.91.6.2353
19 https://doi.org/10.1073/pnas.94.11.5804
20 https://doi.org/10.1073/pnas.94.21.11563
21 https://doi.org/10.1073/pnas.94.4.1426
22 https://doi.org/10.1089/hum.1997.8.2-137
23 https://doi.org/10.1089/hum.1998.9.3-353
24 https://doi.org/10.1089/hum.1998.9.4-591
25 https://doi.org/10.1093/hmg/4.6.993
26 https://doi.org/10.1093/nar/15.3.1311
27 https://doi.org/10.1093/nar/22.3.540
28 https://doi.org/10.1093/oxfordjournals.bmb.a072953
29 https://doi.org/10.1111/1523-1747.ep12319194
30 https://doi.org/10.1126/science.8211118
31 https://doi.org/10.1128/mcb.10.8.4239
32 https://doi.org/10.3892/ijmm.1.1.55
33 schema:datePublished 2000-02-18
34 schema:datePublishedReg 2000-02-18
35 schema:description Hemophilia B is an X-linked genetic disorder that typically results from chronic circulating deficiency of blood coagulation factor IX (FIX) (1). While the occurrence of hemophilia B is significantly less frequent than hemophilia A (factor VIII, deficiency) it has received special attention as a model for gene therapy. This is because hemophilia B is one of the least complicated genetic diseases from the point of view of demonstrating the proof of principle of a gene therapy protocol. Specifically, hemophilia B is a single gene recessive disorder and a wide range of tissues can be targeted for FIX gene delivery and strict regulation of FIX expression is not required. In addition, the 2.8 kb FIX cDNA is much smaller than the 9 kb FVIII cDNA, and FIX expression in transfected mammalian cells has been less problematic than FVIII expression (2). Since clinical severity of bleeding episodes closely corresponds to a patient's FIX activity, achieving even partial restoration of normal FIX levels in the bloodstream can alleviate internal bleeding. Individuals with FIX levels less than 1% of normal experience severe symptomatic episodes but providing roughly 5% of normal levels (i.e., 250 ng/mL plasma) can significantly reduce the frequency and severity of bleeding episodes and reduce long term complications (3). Treatment of hemophilia B primarily relies on intravenous injections of FIX protein purified from pooled human plasma, or very recently, on newly developed recombinant FIX. Treatment is applied typically only when bleeding episodes have occurred or are expected, for example, in case of a trauma or surgery. Although the risk of viral transmission of HIV and hepatitis viruses has been largely eliminated the absolute safety of any product derived from blood cannot be guaranteed. Furthermore, supplies of factor concentrates are limited and costs (especially if prophylactic treatment is being considered) are high. Thus, the application of gene therapy to hemophilia, whereby long-term correction of factor IX deficiency might be achieved, would be extremely useful.
36 schema:genre chapter
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N0c346b67497f4f428f775dd8442809d6
40 schema:name Ex Vivo Stromal Cell Electroporation of Factor IX cDNA for Treatment of Hemophilia B
41 schema:pagination 359-68
42 schema:productId N117c6d56e4354e6899c12cc4eb90f03b
43 N173e052e9a614347b2f9c97542644507
44 N28d34ecc44cd4c01b3b53d3062469c8d
45 Nb51e41c2b72a430aae93e7e0694a20ff
46 schema:publisher Nfb30e964cdd1402886012654cc1e3a96
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046627000
48 https://doi.org/10.1385/1-59259-080-2:359
49 schema:sdDatePublished 2019-04-15T12:34
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Nf3652c177b9a4a4f98138d8a07d9cc90
52 schema:url http://link.springer.com/10.1385/1-59259-080-2:359
53 sgo:license sg:explorer/license/
54 sgo:sdDataset chapters
55 rdf:type schema:Chapter
56 N0c346b67497f4f428f775dd8442809d6 schema:isbn 1-59259-080-2
57 schema:name Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery
58 rdf:type schema:Book
59 N117c6d56e4354e6899c12cc4eb90f03b schema:name dimensions_id
60 schema:value pub.1046627000
61 rdf:type schema:PropertyValue
62 N173e052e9a614347b2f9c97542644507 schema:name pubmed_id
63 schema:value 21445754
64 rdf:type schema:PropertyValue
65 N28d34ecc44cd4c01b3b53d3062469c8d schema:name readcube_id
66 schema:value de1cc25e3050560d521d7340d5197a26bf871e56458579f772abc72f1ae14020
67 rdf:type schema:PropertyValue
68 N3764e26aad7c43b08135a7392165ebf7 rdf:first Ne9ad948341324408827f70a61748cb36
69 rdf:rest Nea4a3a3c1f1c4eca8cf525332d073fa7
70 N3fd7c21825674f5cabcb88b25d12c844 schema:name Genetronics Inc.
71 rdf:type schema:Organization
72 N6687bf5619bf453aa5e4d0555b839c58 rdf:first sg:person.0716725263.03
73 rdf:rest Nf482ac041d524fe685e1f255832422c1
74 N6e9dee0d4108408a96801894a9f4afcb rdf:first sg:person.01144305106.75
75 rdf:rest N9de4c5f09beb4f18b6c4354cc744d14b
76 N9de4c5f09beb4f18b6c4354cc744d14b rdf:first sg:person.01057200577.35
77 rdf:rest N6687bf5619bf453aa5e4d0555b839c58
78 N9fc9992d9eb242288399c53bad08bab5 schema:name University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital
79 rdf:type schema:Organization
80 Nb51e41c2b72a430aae93e7e0694a20ff schema:name doi
81 schema:value 10.1385/1-59259-080-2:359
82 rdf:type schema:PropertyValue
83 Nbbbbb32b839e4c849353ecab162d9c0b schema:name University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital
84 rdf:type schema:Organization
85 Ne1762bc5858c4236a7158cbd22967c7f schema:name Genetronics Inc.
86 rdf:type schema:Organization
87 Ne9ad948341324408827f70a61748cb36 schema:affiliation Ne1762bc5858c4236a7158cbd22967c7f
88 schema:familyName Nolan
89 schema:givenName Edward
90 rdf:type schema:Person
91 Nea4a3a3c1f1c4eca8cf525332d073fa7 rdf:first sg:person.0737341331.81
92 rdf:rest Nf900a2152aec4ea79af2210c9ebc915c
93 Nf3652c177b9a4a4f98138d8a07d9cc90 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 Nf482ac041d524fe685e1f255832422c1 rdf:first sg:person.01210555120.64
96 rdf:rest N3764e26aad7c43b08135a7392165ebf7
97 Nf900a2152aec4ea79af2210c9ebc915c rdf:first sg:person.0726170272.17
98 rdf:rest rdf:nil
99 Nfb30e964cdd1402886012654cc1e3a96 schema:location New Jersey
100 schema:name Humana Press
101 rdf:type schema:Organisation
102 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
103 schema:name Technology
104 rdf:type schema:DefinedTerm
105 anzsrc-for:1004 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical Biotechnology
107 rdf:type schema:DefinedTerm
108 sg:person.01057200577.35 schema:familyName Heller
109 schema:givenName Richard
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35
111 rdf:type schema:Person
112 sg:person.01144305106.75 schema:familyName Jaroszeski
113 schema:givenName Mark J.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75
115 rdf:type schema:Person
116 sg:person.01210555120.64 schema:affiliation N9fc9992d9eb242288399c53bad08bab5
117 schema:familyName Keating
118 schema:givenName Armand
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210555120.64
120 rdf:type schema:Person
121 sg:person.0716725263.03 schema:familyName Gilbert
122 schema:givenName Richard
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03
124 rdf:type schema:Person
125 sg:person.0726170272.17 schema:affiliation N3fd7c21825674f5cabcb88b25d12c844
126 schema:familyName Dev
127 schema:givenName Sukhendu B.
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726170272.17
129 rdf:type schema:Person
130 sg:person.0737341331.81 schema:affiliation Nbbbbb32b839e4c849353ecab162d9c0b
131 schema:familyName Filshie
132 schema:givenName Robin
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737341331.81
134 rdf:type schema:Person
135 sg:pub.10.1007/978-1-4613-8862-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006644940
136 https://doi.org/10.1007/978-1-4613-8862-3_11
137 rdf:type schema:CreativeWork
138 sg:pub.10.1038/38410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048288589
139 https://doi.org/10.1038/38410
140 rdf:type schema:CreativeWork
141 sg:pub.10.1038/nbt1297-1388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014301385
142 https://doi.org/10.1038/nbt1297-1388
143 rdf:type schema:CreativeWork
144 sg:pub.10.1038/ng0293-180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027377728
145 https://doi.org/10.1038/ng0293-180
146 rdf:type schema:CreativeWork
147 sg:pub.10.1038/ng0797-270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038688300
148 https://doi.org/10.1038/ng0797-270
149 rdf:type schema:CreativeWork
150 sg:pub.10.1038/sj.gt.3300548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004830922
151 https://doi.org/10.1038/sj.gt.3300548
152 rdf:type schema:CreativeWork
153 sg:pub.10.1111/1523-1747.ep12319194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030117017
154 https://doi.org/10.1111/1523-1747.ep12319194
155 rdf:type schema:CreativeWork
156 https://app.dimensions.ai/details/publication/pub.1077306574 schema:CreativeWork
157 https://app.dimensions.ai/details/publication/pub.1078637804 schema:CreativeWork
158 https://app.dimensions.ai/details/publication/pub.1082393787 schema:CreativeWork
159 https://app.dimensions.ai/details/publication/pub.1082605286 schema:CreativeWork
160 https://doi.org/10.1016/0006-291x(90)91210-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1003294485
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0006-3495(93)81208-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042582437
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1073/pnas.87.16.6141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028547680
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1073/pnas.91.6.2353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037439633
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1073/pnas.94.11.5804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046830591
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1073/pnas.94.21.11563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032141878
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1073/pnas.94.4.1426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002780220
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1089/hum.1997.8.2-137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059271985
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1089/hum.1998.9.3-353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272262
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1089/hum.1998.9.4-591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272282
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1093/hmg/4.6.993 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645456
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1093/nar/15.3.1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016229210
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1093/nar/22.3.540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004710089
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/oxfordjournals.bmb.a072953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082404554
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1111/1523-1747.ep12319194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030117017
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1126/science.8211118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653632
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1128/mcb.10.8.4239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042061197
193 rdf:type schema:CreativeWork
194 https://doi.org/10.3892/ijmm.1.1.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071505097
195 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...