Reporter/Functional Gene Transfer in Rat Brain View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Toru Nishi , Kimio Yoshizato , Tomoaki Goto , Hideo Takeshima , Shigeo Yamashiro , Jun-ichi Kuratsu , Hideyuki Saya , Yukitaka Ushio

ABSTRACT

Of the many methods and techniques for in vivo gene transfer, some have already been used in clinical trials. In most cases, genes are transferred into tissues using the infectivity of viral particles. However, viral systems have some known drawbacks (1,2). If an efficient and specific transfer method could be developed, naked plasmid DNA would be an ideal system for gene transfer. Plasmid-mediated methods would be economical and easy. Also, the transfer procedure could be easily repeated, as naked plasmid DNA has little antigenicity for the host (3,4). More... »

PAGES

339-48

References to SciGraph publications

  • 1996. Clinical Applications of Electroporation in ELECTRICAL MANIPULATION OF CELLS
  • 1995-08-11. Electroporation for Gene Therapy in ANIMAL CELL ELECTROPORATION AND ELECTROFUSION PROTOCOLS
  • 1998-10. Targeted gene transfer to corneal endothelium in vivo by electric pulse in GENE THERAPY
  • 1982-06. The use of β-galactosidase as a tracer in immunocytochemistry in HISTOCHEMISTRY AND CELL BIOLOGY
  • Book

    TITLE

    Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

    ISBN

    1-59259-080-2

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:339

    DOI

    http://dx.doi.org/10.1385/1-59259-080-2:339

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028013923

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21445752


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