Treatment of Liver Tumors in Rabbit View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Stéphane Orlowski , Lluis M. Mir

ABSTRACT

Electrochemotherapy has been proven to be efficient for the treatment of subcutaneous tumors of different histological types in mice, rats and cats (1-3). Electrochemotherapy is essentially a local treatment. Indeed, it is based on the potentiation of the cytotoxicity of a low-permeant drug, typically bleomycin, by tumor cell permeabilization using brief and intense electric pulses. In the tissues exposed to such electric pulses, the so-called cell electropermeabilization is obtained only in the volume crossed by an electric field of intensity higher than a threshold value (4). The existence of this threshold for tissue permeabilization implies that the potentiation of the cytotoxic drug by the applied electric pulses is limited to the space roughly comprised between the electrodes. In the case of rather small and prominent cutaneous or subcutaneous tumors, it is easy to place two external electrodes on each side of the tumor nodule to be treated and to transcutaneously deliver the permeabilizing electric pulses. For thick and for deep subcutaneous tumors as well as for tumors located in internal organs, this electrode configuration is not appropriate because the electric pulses have to be delivered directly to the tumor tissues. Externally placed electrodes simply do not supply electric fields that extend deep enough for these situations. Intratumoral electric pulse delivery can, however, be achieved using needle-electrodes that are inserted into the tumor volume. We have designed an applicator constituted by multiple parallel and equidistant needles in order to avoid the delivery of very high-voltage electric pulses. A specifically manufactured generator ensures the multiplexed supplying of the electric current to each pair of closest needle electrodes. Thus, the entire tumor volume is divided in small units which are separately permeabilized by the different pairs of closest electrodes. More... »

PAGES

327-32

References to SciGraph publications

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:327

DOI

http://dx.doi.org/10.1385/1-59259-080-2:327

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045500446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445750


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0903", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biomedical Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Jaroszeski", 
        "givenName": "Mark J.", 
        "id": "sg:person.01144305106.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Heller", 
        "givenName": "Richard", 
        "id": "sg:person.01057200577.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gilbert", 
        "givenName": "Richard", 
        "id": "sg:person.0716725263.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Section di Biophysique des Proetines et des Membranes, Department do Biologie Cellulaire et Moleculaire"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orlowski", 
        "givenName": "St\u00e9phane", 
        "id": "sg:person.01104435663.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104435663.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "UMR 1772 CNRS, Institut Gustave-Roussy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mir", 
        "givenName": "Lluis M.", 
        "id": "sg:person.01154353457.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154353457.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.1997.606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001882271", 
          "https://doi.org/10.1038/bjc.1997.606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1997.606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001882271", 
          "https://doi.org/10.1038/bjc.1997.606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-199501000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005823128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00002371-199501000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005823128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1992.tb02727.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009182141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1992.tb02727.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009182141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90045-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015095568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2736(94)90045-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015095568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031714291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0277-5379(91)90064-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039599683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(87)80548-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045995212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048904754", 
          "https://doi.org/10.1038/bjc.1998.354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048904754", 
          "https://doi.org/10.1038/bjc.1998.354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1993.1911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050563053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076022956", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-02-18", 
    "datePublishedReg": "2000-02-18", 
    "description": "Electrochemotherapy has been proven to be efficient for the treatment of subcutaneous tumors of different histological types in mice, rats and cats (1-3). Electrochemotherapy is essentially a local treatment. Indeed, it is based on the potentiation of the cytotoxicity of a low-permeant drug, typically bleomycin, by tumor cell permeabilization using brief and intense electric pulses. In the tissues exposed to such electric pulses, the so-called cell electropermeabilization is obtained only in the volume crossed by an electric field of intensity higher than a threshold value (4). The existence of this threshold for tissue permeabilization implies that the potentiation of the cytotoxic drug by the applied electric pulses is limited to the space roughly comprised between the electrodes. In the case of rather small and prominent cutaneous or subcutaneous tumors, it is easy to place two external electrodes on each side of the tumor nodule to be treated and to transcutaneously deliver the permeabilizing electric pulses. For thick and for deep subcutaneous tumors as well as for tumors located in internal organs, this electrode configuration is not appropriate because the electric pulses have to be delivered directly to the tumor tissues. Externally placed electrodes simply do not supply electric fields that extend deep enough for these situations. Intratumoral electric pulse delivery can, however, be achieved using needle-electrodes that are inserted into the tumor volume. We have designed an applicator constituted by multiple parallel and equidistant needles in order to avoid the delivery of very high-voltage electric pulses. A specifically manufactured generator ensures the multiplexed supplying of the electric current to each pair of closest needle electrodes. Thus, the entire tumor volume is divided in small units which are separately permeabilized by the different pairs of closest electrodes.", 
    "genre": "chapter", 
    "id": "sg:pub.10.1385/1-59259-080-2:327", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "1-59259-080-2"
      ], 
      "name": "Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery", 
      "type": "Book"
    }, 
    "name": "Treatment of Liver Tumors in Rabbit", 
    "pagination": "327-32", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1385/1-59259-080-2:327"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d8bcffa243ce1b21511db36d38b3d2fda64950e97b3b23a002c697bdf708b26b"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1045500446"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21445750"
        ]
      }
    ], 
    "publisher": {
      "location": "New Jersey", 
      "name": "Humana Press", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1385/1-59259-080-2:327", 
      "https://app.dimensions.ai/details/publication/pub.1045500446"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T22:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000271.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1385/1-59259-080-2:327"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:327'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:327'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:327'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1385/1-59259-080-2:327'


 

This table displays all metadata directly associated to this object as RDF triples.

119 TRIPLES      22 PREDICATES      36 URIs      19 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1385/1-59259-080-2:327 schema:about anzsrc-for:09
2 anzsrc-for:0903
3 schema:author N48e1489152f740f3a282a7b67ce4b2e1
4 schema:citation sg:pub.10.1038/bjc.1997.606
5 sg:pub.10.1038/bjc.1998.354
6 https://app.dimensions.ai/details/publication/pub.1076022956
7 https://doi.org/10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co;2-2
8 https://doi.org/10.1006/bbrc.1993.1911
9 https://doi.org/10.1016/0005-2736(94)90045-0
10 https://doi.org/10.1016/0014-5793(87)80548-3
11 https://doi.org/10.1016/0277-5379(91)90064-k
12 https://doi.org/10.1097/00002371-199501000-00004
13 https://doi.org/10.1111/j.1349-7006.1992.tb02727.x
14 schema:datePublished 2000-02-18
15 schema:datePublishedReg 2000-02-18
16 schema:description Electrochemotherapy has been proven to be efficient for the treatment of subcutaneous tumors of different histological types in mice, rats and cats (1-3). Electrochemotherapy is essentially a local treatment. Indeed, it is based on the potentiation of the cytotoxicity of a low-permeant drug, typically bleomycin, by tumor cell permeabilization using brief and intense electric pulses. In the tissues exposed to such electric pulses, the so-called cell electropermeabilization is obtained only in the volume crossed by an electric field of intensity higher than a threshold value (4). The existence of this threshold for tissue permeabilization implies that the potentiation of the cytotoxic drug by the applied electric pulses is limited to the space roughly comprised between the electrodes. In the case of rather small and prominent cutaneous or subcutaneous tumors, it is easy to place two external electrodes on each side of the tumor nodule to be treated and to transcutaneously deliver the permeabilizing electric pulses. For thick and for deep subcutaneous tumors as well as for tumors located in internal organs, this electrode configuration is not appropriate because the electric pulses have to be delivered directly to the tumor tissues. Externally placed electrodes simply do not supply electric fields that extend deep enough for these situations. Intratumoral electric pulse delivery can, however, be achieved using needle-electrodes that are inserted into the tumor volume. We have designed an applicator constituted by multiple parallel and equidistant needles in order to avoid the delivery of very high-voltage electric pulses. A specifically manufactured generator ensures the multiplexed supplying of the electric current to each pair of closest needle electrodes. Thus, the entire tumor volume is divided in small units which are separately permeabilized by the different pairs of closest electrodes.
17 schema:genre chapter
18 schema:inLanguage en
19 schema:isAccessibleForFree false
20 schema:isPartOf N87280b9721be4cca8eeec64dd10e6feb
21 schema:name Treatment of Liver Tumors in Rabbit
22 schema:pagination 327-32
23 schema:productId N52fb3b1f576e44e79579ebc736fb5d0e
24 N71b537cb17fe43ada096aa562d3bd2b1
25 Nc426ba48c9324ee4bd16be1f0c87d70c
26 Ncf267dedb6da41d28b9ea6a26e1072c8
27 schema:publisher Nf1adba5fbdbe40c19dd0a686fa407777
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045500446
29 https://doi.org/10.1385/1-59259-080-2:327
30 schema:sdDatePublished 2019-04-15T22:58
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N945c696d9d254199b45a199c4d272726
33 schema:url http://link.springer.com/10.1385/1-59259-080-2:327
34 sgo:license sg:explorer/license/
35 sgo:sdDataset chapters
36 rdf:type schema:Chapter
37 N1ebb96c53f434dfb980e0cbd3c101ef1 rdf:first sg:person.01104435663.41
38 rdf:rest N56b315abaee742e2bf4656dcde29213c
39 N257b0b0178ad4d59afa2bb20ad22a1ea schema:name UMR 1772 CNRS, Institut Gustave-Roussy
40 rdf:type schema:Organization
41 N2f66c76e063c4eba901cde270406767d rdf:first sg:person.01057200577.35
42 rdf:rest N48d5ce1eddf841c281a5e03ef81bd86e
43 N48d5ce1eddf841c281a5e03ef81bd86e rdf:first sg:person.0716725263.03
44 rdf:rest N1ebb96c53f434dfb980e0cbd3c101ef1
45 N48e1489152f740f3a282a7b67ce4b2e1 rdf:first sg:person.01144305106.75
46 rdf:rest N2f66c76e063c4eba901cde270406767d
47 N52fb3b1f576e44e79579ebc736fb5d0e schema:name pubmed_id
48 schema:value 21445750
49 rdf:type schema:PropertyValue
50 N56b315abaee742e2bf4656dcde29213c rdf:first sg:person.01154353457.84
51 rdf:rest rdf:nil
52 N71b537cb17fe43ada096aa562d3bd2b1 schema:name doi
53 schema:value 10.1385/1-59259-080-2:327
54 rdf:type schema:PropertyValue
55 N87280b9721be4cca8eeec64dd10e6feb schema:isbn 1-59259-080-2
56 schema:name Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery
57 rdf:type schema:Book
58 N945c696d9d254199b45a199c4d272726 schema:name Springer Nature - SN SciGraph project
59 rdf:type schema:Organization
60 Nb197b517c0f4421d8622a56fbea1d329 schema:name Section di Biophysique des Proetines et des Membranes, Department do Biologie Cellulaire et Moleculaire
61 rdf:type schema:Organization
62 Nc426ba48c9324ee4bd16be1f0c87d70c schema:name dimensions_id
63 schema:value pub.1045500446
64 rdf:type schema:PropertyValue
65 Ncf267dedb6da41d28b9ea6a26e1072c8 schema:name readcube_id
66 schema:value d8bcffa243ce1b21511db36d38b3d2fda64950e97b3b23a002c697bdf708b26b
67 rdf:type schema:PropertyValue
68 Nf1adba5fbdbe40c19dd0a686fa407777 schema:location New Jersey
69 schema:name Humana Press
70 rdf:type schema:Organisation
71 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
72 schema:name Engineering
73 rdf:type schema:DefinedTerm
74 anzsrc-for:0903 schema:inDefinedTermSet anzsrc-for:
75 schema:name Biomedical Engineering
76 rdf:type schema:DefinedTerm
77 sg:person.01057200577.35 schema:familyName Heller
78 schema:givenName Richard
79 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057200577.35
80 rdf:type schema:Person
81 sg:person.01104435663.41 schema:affiliation Nb197b517c0f4421d8622a56fbea1d329
82 schema:familyName Orlowski
83 schema:givenName Stéphane
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104435663.41
85 rdf:type schema:Person
86 sg:person.01144305106.75 schema:familyName Jaroszeski
87 schema:givenName Mark J.
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144305106.75
89 rdf:type schema:Person
90 sg:person.01154353457.84 schema:affiliation N257b0b0178ad4d59afa2bb20ad22a1ea
91 schema:familyName Mir
92 schema:givenName Lluis M.
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154353457.84
94 rdf:type schema:Person
95 sg:person.0716725263.03 schema:familyName Gilbert
96 schema:givenName Richard
97 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716725263.03
98 rdf:type schema:Person
99 sg:pub.10.1038/bjc.1997.606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001882271
100 https://doi.org/10.1038/bjc.1997.606
101 rdf:type schema:CreativeWork
102 sg:pub.10.1038/bjc.1998.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048904754
103 https://doi.org/10.1038/bjc.1998.354
104 rdf:type schema:CreativeWork
105 https://app.dimensions.ai/details/publication/pub.1076022956 schema:CreativeWork
106 https://doi.org/10.1002/1097-0142(19931215)72:12<3694::aid-cncr2820721222>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031714291
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1006/bbrc.1993.1911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050563053
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1016/0005-2736(94)90045-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015095568
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1016/0014-5793(87)80548-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045995212
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/0277-5379(91)90064-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1039599683
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1097/00002371-199501000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005823128
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1111/j.1349-7006.1992.tb02727.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009182141
119 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...