Treatment of Rat Bladder Cancer With Electrochemotherapy In Vivo View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2000-02-18

AUTHORS

Mark J. Jaroszeski , Richard Heller , Richard Gilbert , Yoko Kubota , Teruhiro Nakada , Isoji Sasagawa

ABSTRACT

It has been reported that the application of strong electric fields across a cell results in the formation and expansion of temporary membrane pores. Electrochemotherapy is a method which enhances the effectiveness of chemotherapeutic agents by administrating the drugs in combination with short intense electric pulses (1). Cell electropermeability allows nonpermeant or weakly permeant drugs to enter the cells. Electrochemotherapy is effective because electric pulses permeate any type of tumor cell membrane in vitro and in vivo. We have shown that electropermeabilization induces a twofold increase in the concentration of Bleomycin, in bladder cancer cells in vitro and in normal bladder tissue of rats in vivo (2). Here we introduce our method to assess the effectiveness of this therapy for rat's bladder cancer. More... »

PAGES

293-8

References to SciGraph publications

Book

TITLE

Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery

ISBN

1-59259-080-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1385/1-59259-080-2:293

DOI

http://dx.doi.org/10.1385/1-59259-080-2:293

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018788257

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21445745


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